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PFDN1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203820
SDS-Page
Unit / Price
0.01 mg  /  $310 +1 FREE 8GB USB
0.05 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PFDN1, Recombinant Protein

 Also Known As   

PFDN1, 14-122aa, Human, His tag, E Coli

 Product Synonym Names    Prefoldin subunit 1; PDF; PFD1
 Product Gene Name   

PFDN1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MTELQAKVID TQQKVKLADI QIEQLNRTKK HAHLTDTEIM TLVDETNMYE GVGRMFILQS KEAIHSQLLE KQKIAEEKIK ELEQKKSYLE RSVKEAEDNI REMLMARRAQ
 OMIM    Y17392 mRNA
 3D Structure    ModBase 3D Structure for O60925
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PFDN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PFDN1 recombinant protein

   PFDN1 is one of sixsubunits of prefoldin, a heterohexameric chaperone protein which assists in the correct folding of other proteins. This protein delivers nonnative target proteins, principally actins and tubulins, to the eukaryotic cytosolic chaperonin for facilitated folding. Defects in PFDN1 displayed phenotypes characteristic of defects in cytoskeletal function, including manifestations of ciliary dyskinesia, neuronal loss, and defects in B and T cell development and function. Recombinant human PFDN1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for PFDN1 recombinant protein    Heat Shock Proteins
 Applications Tested/Suitable for PFDN1 recombinant protein   

SDS-PAGE

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 SDS-Page of PFDN1 recombinant protein    PFDN1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PFDN1. It may not necessarily be applicable to this product.
 NCBI GI #    21536449
 NCBI GeneID    5201
 NCBI Accession #    NP_002613 [Other Products]
 NCBI GenBank Nucleotide #    NM_002622.4 [Other Products]
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 UniProt Primary Accession #    O60925 [Other Products]
 UniProt Secondary Accession #    Q53F95; Q96EX6; B2RD02 [Other Products]
 UniProt Related Accession #    O60925 [Other Products]
 Molecular Weight    15.0kDa (130aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    prefoldin subunit 1
 NCBI Official Synonym Full Names    prefoldin subunit 1
 NCBI Official Symbol    PFDN1 [Similar Products]
 NCBI Official Synonym Symbols   
PDF; PFD1
[Similar Products]
 NCBI Protein Information    prefoldin subunit 1
 UniProt Protein Name    Prefoldin subunit 1
 Protein Family    Prefoldin
 UniProt Gene Name    PFDN1 [Similar Products]
 UniProt Synonym Gene Names    PFD1 [Similar Products]
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 NCBI Summary for PFDN1    This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PFDN1    Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
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Product References and Citations for PFDN1 recombinant protein

   Ruley HE., et al. (2008) J Immunol. 181 (1):476-84.; Cowan NJ., et al (2004) J Biol Chem. 279 (6):4196-203.;
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 Research Articles on PFDN1    1. Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PFDN1 recombinant proteinPathways associated with PFDN1 recombinant protein
 Reference Product  PubMed Publications
 TCP1 recombinant protein  >1 publications with PFDN1 and TCP1
 ACTB recombinant protein  >1 publications with PFDN1 and ACTB
 Products by Pathway  Pathway Diagram
 Chaperonin-mediated Protein Folding Pathway antibodies  Chaperonin-mediated Protein Folding Pathway Diagram
 Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway antibodies  Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Prefoldin Mediated Transfer Of Substrate To CCT/TriC Pathway antibodies  Prefoldin Mediated Transfer Of Substrate To CCT/TriC Pathway Diagram
 Protein Folding Pathway antibodies  Protein Folding Pathway Diagram
Diseases associated with PFDN1 recombinant proteinOrgans/Tissues associated with PFDN1 recombinant protein
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >1 publications with PFDN1 and Lung Neoplasms
 Brain Diseases Antibodies  >1 publications with PFDN1 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with PFDN1 and Brain
 Thymus Antibodies  >1 publications with PFDN1 and Thymus
 Spleen Antibodies  >1 publications with PFDN1 and Spleen
 Bone Antibodies  >1 publications with PFDN1 and Bone
 Blood Antibodies  >1 publications with PFDN1 and Blood
 Bone Marrow Antibodies  >1 publications with PFDN1 and Bone Marrow
 Lung Antibodies  >1 publications with PFDN1 and Lung
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