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PFKM recombinant protein

Scan QR to view Datasheet Catalog #    MBS203553
SDS-Page
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PFKM, Recombinant Protein

 Also Known As   

PFKM, 1-780aa, Human, His tag, E Coli

 Product Synonym Names    6-Phosphofructokinase muscle type; GSD7; PFK-1; PFK1; PFKA; PFKX; 6-Phosphofructokinase; muscle type 6 Phosphofructokinase Muscle Type; EC 2.7.1.11; MGC8699; PFKL; PFKM; PFKP; Phosphofructo 1 Kinase Isozyme A; Phosphofructokinase 1; Phosphofructokinase M; Phosphofructokinase; muscle; Phosphofructokinase; muscle type; Phosphofructokinase; polypeptide X; Phosphohexokinase.
 Product Gene Name   

PFKM recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MTHEEHHAAK TLGIGKAIAV LTSGGDAQGM NAAVRAVVRV GIFTGARVFF VHEGYQGLVD GGDHIKEATW ESVSMMLQLG GTVIGSARCK DFREREGRLR AAYNLVKRGI TNLCVIGGDG SLTGADTFRS EWSDLLSDLQ KAGKITDEEA TKSSYLNIVG LVGSIDNDFC GTDMTIGTDS ALHRIMEIVD AITTTAQSHQ RTFVLEVMGR HCGYLALVTS LSCGADWVFI PECPPDDDWE EHLCRRLSET RTRGSRLNII IVAEGAIDKN GKPITSEDIK NLVVKRLGYD TRVTVLGHVQ RGGTPSAFDR ILGSRMGVEA VMALLEGTPD TPACVVSLSG NQAVRLPLME CVQVTKDVTK AMDEKKFDEA LKLRGRSFMN NWEVYKLLAH VRPPVSKSGS HTVAVMNVGA PAAGMNAAVR STVRIGLIQG NRVLVVHDGF EGLAKGQIEE AGWSYVGGWT GQGGSKLGTK RTLPKKSFEQ ISANITKFNI QGLVIIGGFE AYTGGLELME GRKQFDELCI PFVVIPATVS NNVPGSDFSV GADTALNTIC TTCDRIKQSA AGTKRRVFII ETMGGYCGYL ATMAGLAAGA DAAYIFEEPF TIRDLQANVE HLVQKMKTTV KRGLVLRNEK CNENYTTDFI FNLYSEEGKG IFDSRKNVLG HMQQGGSPTP FDRNFATKMG AKAMNWMSGK IKESYRNGRI FANTPDSGCV LGMRKRALVF QPVAELKDQT DFEHRIPKEQ WWLKLRPILK ILAKYEIDLD TSDHAHLEHI TRKRSGEAAV
 OMIM    M59741
 3D Structure
   ModBase 3D Structure for P08237
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 Host    E Coli
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 Purity/Purification    > 80% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 5mM DTT, 0.2 M NaCl, and 20% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PFKM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PFKM recombinant protein

   PFKM is regulatory glycolytic enzymes that convert fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Recombinant human PFKM protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for PFKM recombinant protein    Cancer
 Applications Tested/Suitable for PFKM recombinant protein   

SDS-PAGE

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 SDS-Page of PFKM recombinant protein    PFKM recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PFKM. It may not necessarily be applicable to this product.
 NCBI GI #    4505749
 NCBI GeneID    5213
 NCBI Accession #    NP_000280 [Other Products]
 NCBI GenBank Nucleotide #    NM_000289.5 [Other Products]
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 UniProt Primary Accession #    P08237 [Other Products]
 UniProt Secondary Accession #    Q16814; Q16815; Q6ZTT1; J3KNX3 [Other Products]
 UniProt Related Accession #    P08237 [Other Products]
 Molecular Weight    87.3 kDa (800aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    ATP-dependent 6-phosphofructokinase, muscle type isoform 2
 NCBI Official Synonym Full Names    phosphofructokinase, muscle
 NCBI Official Symbol    PFKM [Similar Products]
 NCBI Official Synonym Symbols   
GSD7; PFK1; PFKA; PFKX; PFK-1; PFK-A; ATP-PFK; PPP1R122
[Similar Products]
 NCBI Protein Information    ATP-dependent 6-phosphofructokinase, muscle type
 UniProt Protein Name    ATP-dependent 6-phosphofructokinase, muscle type
 UniProt Synonym Protein Names   
6-phosphofructokinase type A; Phosphofructo-1-kinase isozyme A; PFK-A; Phosphohexokinase
 Protein Family    ATP-dependent 6-phosphofructokinase
 UniProt Gene Name    PFKM [Similar Products]
 UniProt Synonym Gene Names    PFKX; ATP-PFK; PFK-M [Similar Products]
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 NCBI Summary for PFKM    Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
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 UniProt Comments for PFKM    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
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Product References and Citations for PFKM recombinant protein

   Martinez-Costa OH., et al. (2007) FEBS Lett. 581 (16):3033-8. ; Kim JW., et al. (2004) Mol Cell Biol. 24 (13):5923-36.;
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 Research Articles on PFKM    1. Data indicate that 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase3 (PFKFB3) and phosphofructokinase (PFK1) expression allows discrimination between induced pluripotent stem cells (iPS) and cancer stem cells (CSCs).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PFKM recombinant proteinPathways associated with PFKM recombinant protein
 Reference Product  PubMed Publications
 PFKL recombinant protein  >9 publications with PFKM and PFKL
 HK2 recombinant protein  >6 publications with PFKM and HK2
 HK1 recombinant protein  >3 publications with PFKM and HK1
 PKM recombinant protein  >2 publications with PFKM and PKM
 PFKFB3 recombinant protein  >2 publications with PFKM and PFKFB3
 ALDOA recombinant protein  >2 publications with PFKM and ALDOA
 ALDOC recombinant protein  >1 publications with PFKM and ALDOC
 GPI recombinant protein  >1 publications with PFKM and GPI
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
Diseases associated with PFKM recombinant proteinOrgans/Tissues associated with PFKM recombinant protein
 Disease Name  Pubmed Publications
 Glycogen Storage Disease Type VII Antibodies  >6 publications with PFKM and Glycogen Storage Disease Type VII
 Liver Diseases Antibodies  >4 publications with PFKM and Liver Diseases
 Abnormalities, Multiple Antibodies  >4 publications with PFKM and Abnormalities, Multiple
 Anemia Antibodies  >4 publications with PFKM and Anemia
 Cardiovascular Diseases Antibodies  >2 publications with PFKM and Cardiovascular Diseases
 Hypertrophy Antibodies  >2 publications with PFKM and Hypertrophy
 Drug-Related Side Effects and Adverse Reactions Antibodies  >2 publications with PFKM and Drug-Related Side Effects and Adverse Reactions
 Poisoning Antibodies  >2 publications with PFKM and Poisoning
 Breast Neoplasms Antibodies  >2 publications with PFKM and Breast Neoplasms
 Heart Diseases Antibodies  >2 publications with PFKM and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >45 publications with PFKM and Muscle
 Liver Antibodies  >12 publications with PFKM and Liver
 Blood Antibodies  >11 publications with PFKM and Blood
 Heart Antibodies  >6 publications with PFKM and Heart
 Brain Antibodies  >4 publications with PFKM and Brain
 Lung Antibodies  >3 publications with PFKM and Lung
 Eye Antibodies  >2 publications with PFKM and Eye
 Connective Tissue Antibodies  >2 publications with PFKM and Connective Tissue
 Testis Antibodies  >2 publications with PFKM and Testis
 Prostate Antibodies  >1 publications with PFKM and Prostate
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