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PGAM1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203464
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PGAM1, Recombinant Protein

★Popular Item★
 Also Known As   

PGAM1, 1-254aa, Human, His tag, E Coli

 Product Synonym Names    Phosphoglycerate mutase 1; Phosphoglycerate mutase isozyme B; PGAM-B; PGAMA; Phosphoglycerate mutase 1
 Product Gene Name   

PGAM1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MAAYKLVLIR HGESAWNLEN RFSGWYDADL SPAGHEEAKR GGQALRDAGY EFDICFTSVQ KRAIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSCESLKDTI ARALPFWNEE IVPQIKEGKR VLIAAHGNSL RGIVKHLEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVR KAMEAVAAQG KAKK
 OMIM    J04173 mRNA
 3D Structure    ModBase 3D Structure for P18669
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 1mM DTT
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PGAM1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PGAM1 recombinant protein

   PGAM1 belongs to the phosphoglycerate mutase family. This protein is important components of glucose and 2,3-BPGA (2,3-bisphosphoglycerate) metabolism and catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). Mutations in this protein cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. Recombinant human PGAM protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for PGAM1 recombinant protein    Cancer
 Applications Tested/Suitable for PGAM1 recombinant protein   

SDS-PAGE

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 SDS-Page of PGAM1 recombinant protein    PGAM1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PGAM1. It may not necessarily be applicable to this product.
 NCBI GI #    4505753
 NCBI GeneID    5223
 NCBI Accession #    NP_002620 [Other Products]
 NCBI GenBank Nucleotide #    NM_002629.3 [Other Products]
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 UniProt Primary Accession #    P18669 [Other Products]
 UniProt Secondary Accession #    Q9BWC0 [Other Products]
 UniProt Related Accession #    P18669 [Other Products]
 Molecular Weight    30.9 kDa (274aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    phosphoglycerate mutase 1 isoform 1
 NCBI Official Synonym Full Names    phosphoglycerate mutase 1
 NCBI Official Symbol    PGAM1 [Similar Products]
 NCBI Official Synonym Symbols   
PGAMA; PGAM-B; HEL-S-35
[Similar Products]
 NCBI Protein Information    phosphoglycerate mutase 1
 UniProt Protein Name    Phosphoglycerate mutase 1
 UniProt Synonym Protein Names   
BPG-dependent PGAM 1; Phosphoglycerate mutase isozyme B; PGAM-B
 Protein Family    Phosphoglycerate mutase
 UniProt Gene Name    PGAM1 [Similar Products]
 UniProt Synonym Gene Names    PGAMA; PGAM-B [Similar Products]
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 NCBI Summary for PGAM1    The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
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 UniProt Comments for PGAM1    Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
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Product References and Citations for PGAM1 recombinant protein

   Sakoda S., et al. (1988) J Biol Chem. 263 (32):16899-905. ; Junien C., et al. (1982) Ann Genet. 25 (1):25-7.;
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 Research Articles on PGAM1    1. When BPGM is knocked out, 1,3-BPG can directly phosphorylate PGAM1. In this case, PGAM1 phosphorylation and activity are decreased, but nevertheless sufficient to maintain normal glycolytic flux and cellular growth rate.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PGAM1 recombinant proteinPathways associated with PGAM1 recombinant protein
 Reference Product  PubMed Publications
 ENO1 recombinant protein  >8 publications with PGAM1 and ENO1
 GAPDH recombinant protein  >5 publications with PGAM1 and GAPDH
 TPI1 recombinant protein  >4 publications with PGAM1 and TPI1
 PGK1 recombinant protein  >4 publications with PGAM1 and PGK1
 ALDOC recombinant protein  >2 publications with PGAM1 and ALDOC
 PKM recombinant protein  >2 publications with PGAM1 and PKM
 ENO2 recombinant protein  >2 publications with PGAM1 and ENO2
 Products by Pathway  Pathway Diagram
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 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Cori Cycle Pathway antibodies  Cori Cycle Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Glucagon Signaling Pathway antibodies  Glucagon Signaling Pathway Diagram
 Gluconeogenesis Pathway antibodies  Gluconeogenesis Pathway Diagram
Diseases associated with PGAM1 recombinant proteinOrgans/Tissues associated with PGAM1 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >6 publications with PGAM1 and Carcinoma
 Disease Models, Animal Antibodies  >5 publications with PGAM1 and Disease Models, Animal
 Adenocarcinoma Antibodies  >3 publications with PGAM1 and Adenocarcinoma
 Carcinoma, Squamous Cell Antibodies  >2 publications with PGAM1 and Carcinoma, Squamous Cell
 Liver Diseases Antibodies  >2 publications with PGAM1 and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with PGAM1 and Kidney Diseases
 Fatty Liver Antibodies  >1 publications with PGAM1 and Fatty Liver
 Hyperplasia Antibodies  >1 publications with PGAM1 and Hyperplasia
 Inflammation Antibodies  >1 publications with PGAM1 and Inflammation
 Necrosis Antibodies  >1 publications with PGAM1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with PGAM1 and Brain
 Blood Antibodies  >9 publications with PGAM1 and Blood
 Lung Antibodies  >5 publications with PGAM1 and Lung
 Muscle Antibodies  >5 publications with PGAM1 and Muscle
 Testis Antibodies  >4 publications with PGAM1 and Testis
 Heart Antibodies  >4 publications with PGAM1 and Heart
 Liver Antibodies  >4 publications with PGAM1 and Liver
 Kidney Antibodies  >3 publications with PGAM1 and Kidney
 Ovary Antibodies  >2 publications with PGAM1 and Ovary
 Prostate Antibodies  >2 publications with PGAM1 and Prostate
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