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PGP9.5 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203019
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PGP9.5, Recombinant Protein

 Also Known As   

PGP9.5, 1-223aa, Human, E Coli (Bioactivity Validated)

 Product Synonym Names    ubiquitin carboxyl-terminal esterase L1; uCHL1; PGP9.5; 1-223aa; uCH-L1; EC 3.4.19.12; ubiquitin thioesterase L1; Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin carboxyl-terminal esterase L1 Gracile axonal dystrophy; Neuron cytoplasmic protein 9.5; Park 5; Parkinson Disease 5; PGP95; uCH L1; Protein gene product 9.5; ubiquitin C terminal esterase L1; ubiquitin C terminal hydrolase (neuron specific); ubiquitin carboxyl terminal esterase L1; ubiquitin carboxyl terminal hydrolase isozyme L1; ubiquitin thiolesterase; ubiquitin thiolesterase L1.
 Product Gene Name   

PGP9.5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MQLKPMEINP EMLNKVLSRL GVAGQWRFVD VLGLEEESLG SVPAPACALL LLFPLTAQHE NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLGFED GSVLKQFLSE TEKMSPEDRA KCFEKNEAIQ AAHDAVAQEG QCRVDDKVNF HFILFNNVDG HLYELDGRMP FPVNHGASSE DTLLKDAAKV CREFTEREQG EVRFSAVALC KAA
 OMIM    AC095043 Genomic DNA
 3D Structure    ModBase 3D Structure for P09936
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl pH8.0, 2mM EDTA
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Biological Activity    Specific activity is > 150 pmol/min/ug, and is defined as the amount of enzyme that hydrolysis 1.0 pmole of ubiquitin-AMC per minute at pH 7.5, at 37C.
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PGP9.5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PGP9.5 recombinant protein

   PGP9.5/uCH-L1 is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. PGP9.5 is a component of the ubiquitin system, which has a fundamental role in regulating various biological activities. PGP9.5 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility. Recombinant PGP9.5 protein was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for PGP9.5 recombinant protein    Neuroscience
 Applications Tested/Suitable for PGP9.5 recombinant protein   

SDS-PAGE

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 SDS-Page of PGP9.5 recombinant protein    PGP9.5 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PGP9.5. It may not necessarily be applicable to this product.
 NCBI GI #    21361091
 NCBI GeneID    7345
 NCBI Accession #    NP_004172 [Other Products]
 NCBI GenBank Nucleotide #    NM_004181.4 [Other Products]
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 UniProt Primary Accession #    P09936 [Other Products]
 UniProt Secondary Accession #    Q4W5K6; Q71UM0 [Other Products]
 UniProt Related Accession #    P09936 [Other Products]
 Molecular Weight    24.8 kDa (223 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
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 NCBI Official Full Name    ubiquitin carboxyl-terminal hydrolase isozyme L1
 NCBI Official Synonym Full Names    ubiquitin C-terminal hydrolase L1
 NCBI Official Symbol    UCHL1 [Similar Products]
 NCBI Official Synonym Symbols   
NDGOA; PARK5; PGP95; SPG79; PGP9.5; Uch-L1; HEL-117; PGP 9.5; HEL-S-53
[Similar Products]
 NCBI Protein Information    ubiquitin carboxyl-terminal hydrolase isozyme L1
 UniProt Protein Name    Ubiquitin carboxyl-terminal hydrolase isozyme L1
 UniProt Synonym Protein Names   
Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1
 UniProt Gene Name    UCHL1 [Similar Products]
 UniProt Synonym Gene Names    UCH-L1; PGP9.5 [Similar Products]
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 NCBI Summary for PGP9.5    The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
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 UniProt Comments for PGP9.5    Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
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Product References and Citations for PGP9.5 recombinant protein

   Sakurai M., et al. (2006) Cell 119, 162-171.; Liu Y., et al. (2002) Cell. 111 (2):209-18.;
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 Research Articles on PGP9.5    1. UCHL1 localizes to TTAGGG repeats at telomeres and interstitial telomeric sequences. A weak or transient interaction between UCHL1 and the shelterin complex was confirmed by immunoprecipitation and proximity ligation assays.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PGP9.5 recombinant proteinPathways associated with PGP9.5 recombinant protein
 Reference Product  PubMed Publications
 PARK2 recombinant protein  >104 publications with PGP9.5 and PARK2
 SNCA recombinant protein  >33 publications with PGP9.5 and SNCA
 UCHL3 recombinant protein  >18 publications with PGP9.5 and UCHL3
 COPS5 recombinant protein  >1 publications with PGP9.5 and COPS5
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Deubiquitination Pathway antibodies  Deubiquitination Pathway Diagram
 Hepatitis C And Hepatocellular Carcinoma Pathway antibodies  Hepatitis C And Hepatocellular Carcinoma Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Proteasome Degradation Pathway antibodies  Proteasome Degradation Pathway Diagram
 UCH Proteinases Pathway antibodies  UCH Proteinases Pathway Diagram
Diseases associated with PGP9.5 recombinant proteinOrgans/Tissues associated with PGP9.5 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >320 publications with PGP9.5 and Nervous System Diseases
 Brain Diseases Antibodies  >213 publications with PGP9.5 and Brain Diseases
 Disease Models, Animal Antibodies  >124 publications with PGP9.5 and Disease Models, Animal
 Peripheral Nervous System Diseases Antibodies  >76 publications with PGP9.5 and Peripheral Nervous System Diseases
 Inflammation Antibodies  >71 publications with PGP9.5 and Inflammation
 Cardiovascular Diseases Antibodies  >53 publications with PGP9.5 and Cardiovascular Diseases
 Nerve Degeneration Antibodies  >43 publications with PGP9.5 and Nerve Degeneration
 Necrosis Antibodies  >31 publications with PGP9.5 and Necrosis
 Brain Injuries Antibodies  >30 publications with PGP9.5 and Brain Injuries
 Lung Diseases Antibodies  >28 publications with PGP9.5 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >392 publications with PGP9.5 and Nerve
 Brain Antibodies  >220 publications with PGP9.5 and Brain
 Skin Antibodies  >160 publications with PGP9.5 and Skin
 Muscle Antibodies  >116 publications with PGP9.5 and Muscle
 Vascular Antibodies  >87 publications with PGP9.5 and Vascular
 Bone Antibodies  >77 publications with PGP9.5 and Bone
 Ganglia Antibodies  >70 publications with PGP9.5 and Ganglia
 Lymph Antibodies  >67 publications with PGP9.5 and Lymph
 Lymph Node Antibodies  >65 publications with PGP9.5 and Lymph Node
 Intestine Antibodies  >63 publications with PGP9.5 and Intestine
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