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PINX1 recombinant protein :: PIN2-Interacting Protein 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143904 PINX1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,035 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PIN2-Interacting Protein 1 (PINX1), Recombinant Protein

 Also Known As   

Recombinant Human PIN2-Interacting Protein 1

 Product Synonym Names    PINX1 Human; PIN2-Interacting Protein 1 Human Recombinant; PINX1; LPTL; LPTS; MGC8850; FLJ20565; Pin2-interacting protein X1; TRF1-interacting protein 1; Liver-related putative tumor suppressor; Protein 67-11-3
 Product Gene Name   

PINX1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEH GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKINKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK.
 OMIM    606505
 3D Structure    ModBase 3D Structure for Q96BK5
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by analysis by SDS-PAGE.
 Form/Format    The PINX1 protein contains 20mM Tris-HCl buffer pH-8, 1mM DTT and 10% glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of PINX1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PINX1 recombinant protein

   Description: Recombinant Human PINX1 produced in E Coli is a single, non-glycosylated polypeptide chain containing 348 amino acids (1-328 a.a) and having a molecular mass of 39.1 kDa. PINX1 is fused to 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: PINX1 is a common expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains a Telomerase Inhibiting Domain that is caable of binding MCRS1, TERT and TERF1. PINX1 has been shown to be a potent telomerase inhibitor and putative tumor suppressor. PINX1 is recruited to chromosome periphery by Nucleolin, their complex is necessary for faithful chromosome congression. PINX1 regulates the nucleolar accumulation and telomeric association of TRF1. PINX1 is involved in gastric cancer development. PINX1 expression is a sign of gastric cancer development. Constitutive expression of PINX1 attributes to telomere maintenance by telomerase and tumorigenicity in cancer cells.
 Product Categories/Family for PINX1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for PINX1. It may not necessarily be applicable to this product.
 NCBI GI #    547234890
 NCBI GeneID    54984
 NCBI Accession #    NP_001271285.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001284356.1 [Other Products]
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 UniProt Primary Accession #    Q96BK5 [Other Products]
 UniProt Secondary Accession #    Q548A5; Q6QWG9; Q7Z7J8; Q96QD7; Q9HBU7; Q9NWW2; B2R9B1 [Other Products]
 UniProt Related Accession #    Q96BK5 [Other Products]
 Molecular Weight    19,714 Da
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 NCBI Official Full Name    PIN2/TERF1-interacting telomerase inhibitor 1 isoform 2
 NCBI Official Synonym Full Names    PIN2/TERF1 interacting, telomerase inhibitor 1
 NCBI Official Symbol    PINX1 [Similar Products]
 NCBI Official Synonym Symbols   
LPTL; LPTS
[Similar Products]
 NCBI Protein Information    PIN2/TERF1-interacting telomerase inhibitor 1; 67-11-3 protein; PIN2 interacting protein 1; PIN2-interacting protein 1; TRF1-interacting protein 1; hepatocellular carcinoma-related putative tumor suppressor; liver-related putative tumor suppressor; pin2-interacting protein X1; protein 67-11-3
 UniProt Protein Name    PIN2/TERF1-interacting telomerase inhibitor 1
 UniProt Synonym Protein Names   
Liver-related putative tumor suppressor; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1
 Protein Family    PIN2/TERF1-interacting telomerase inhibitor
 UniProt Gene Name    PINX1 [Similar Products]
 UniProt Synonym Gene Names    LPTL; LPTS [Similar Products]
 UniProt Entry Name    PINX1_HUMAN
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 UniProt Comments for PINX1    PINX1: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. Belongs to the PINX1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Inhibitor; Nucleolus

Chromosomal Location of Human Ortholog: 8p23

Cellular Component: nucleoplasm; kinetochore; nuclear chromosome; chromosome, telomeric region; mitochondrion; intracellular membrane-bound organelle; cytoplasm; nucleolus; spindle; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; negative regulation of telomerase activity; regulation of telomerase activity; telomere maintenance via telomerase; mitotic metaphase plate congression
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 Research Articles on PINX1    1. Data confirmed that levels of PinX1 and caspase 3, 8 and 9 expression were closely linked to the poor prognosis of colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PINX1 recombinant proteinDiseases associated with PINX1 recombinant protein
 Products by Pathway  Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >7 publications with PINX1 and Adenocarcinoma
 Liver Neoplasms Antibodies  >7 publications with PINX1 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with PINX1 and Cell Transformation, Neoplastic
 Genital Diseases, Male Antibodies  >2 publications with PINX1 and Genital Diseases, Male
 Cardiovascular Diseases Antibodies  >2 publications with PINX1 and Cardiovascular Diseases
 Uterine Cervical Neoplasms Antibodies  >2 publications with PINX1 and Uterine Cervical Neoplasms
 Fetal Death Antibodies  >1 publications with PINX1 and Fetal Death
 Neoplasm Metastasis Antibodies  >1 publications with PINX1 and Neoplasm Metastasis
 Ovarian Diseases Antibodies  >1 publications with PINX1 and Ovarian Diseases
Organs/Tissues associated with PINX1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >11 publications with PINX1 and Liver
 Stomach Antibodies  >6 publications with PINX1 and Stomach
 Lymph Antibodies  >4 publications with PINX1 and Lymph
 Lymph Node Antibodies  >4 publications with PINX1 and Lymph Node
 Brain Antibodies  >4 publications with PINX1 and Brain
 Embryonic Tissue Antibodies  >3 publications with PINX1 and Embryonic Tissue
 Lung Antibodies  >2 publications with PINX1 and Lung
 Prostate Antibodies  >2 publications with PINX1 and Prostate
 Ovary Antibodies  >1 publications with PINX1 and Ovary
 Heart Antibodies  >1 publications with PINX1 and Heart
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