Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow PMM2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • ADA (Adenosine Deaminase) CLIA Kit
 • Donkey anti Chicken IgY (H + L) (12 nm Gold Colloid) Colloidal Gold & Silver
 • dachsous 1 (Drosophila) (DCHS1) ELISA Kit
 • XBP1 - TREB5 Peptide
 • beta-Catenin (CTNNB1) Antibody
 • S100A7 ELISA Kit
 • Alkaline Phosphatase (ALP) Protein
 • Albumin Native Protein
 • PTGES3 Antibody
 • AIFM3 Peptide
 • GDF1 ELISA Kit
 • Intestinal fatty acid binding protein (IFABP) ELISA Kit
 • Epstein Barr Virus, Nuclear Antigen Antibody
 • ASB9 cDNA Clone
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

PMM2 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203565
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PMM2, Recombinant Protein

 Also Known As   

PMM2, 1-246aa, Human, His tag, E Coli

 Product Synonym Names    Phosphomannomutase 2; CDG1; CDG1a; CDGS; Phosphomannomutase 2
 Product Gene Name   

PMM2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHHHHH SSGLVPRGSH MAAPGPALCL FDVDGTLTAP RQKITKEMDD FLQKLRQKIK IGVVGGSDFE KVQEQLGNDV VEKYDYVFPE NGLVAYKDGK LLCRQNIQSH LGEALIQDLI NYCLSYIAKI KLPKKRGTFI EFRNGMLNVS PIGRSCSQEE RIEFYELDKK ENIRQKFVAD LRKEFAGKGL TFSIGGQISF DVFPDGWDKR YCLRHVENDG YKTIYFFGDK TMPGGNDHEI FTDPRTMGYS VTAPEDTRRI CELLFS
 OMIM    U85773 mRNA
 3D Structure    ModBase 3D Structure for O15305
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl.
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
Section Bar
 Antigen Species    Human
 Tag Information    His-tag
Section Bar
 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PMM2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for PMM2 recombinant protein

   PMM2, also known as Phosphomannomutase 2, belongs to the eukaryotic PMM family. PMM2 is involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. It catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate. Mutations in PMM2 are associated with Congenital disorders of glycosylation (CDG)-Ia, an autosomal recessive disorder characterized by central nervous system dysfunction and multiorgan failure. Recombinant human PMM2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for PMM2 recombinant protein    Metabolism
 Applications Tested/Suitable for PMM2 recombinant protein   

SDS-PAGE

Section Bar
 SDS-Page of PMM2 recombinant protein    PMM2 recombinant protein SDS-Page image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PMM2. It may not necessarily be applicable to this product.
 NCBI GI #    4557839
 NCBI GeneID    5373
 NCBI Accession #    NP_000294 [Other Products]
 NCBI GenBank Nucleotide #    NM_000303.2 [Other Products]
Section Bar
 UniProt Primary Accession #    O15305 [Other Products]
 UniProt Secondary Accession #    A8K672; B7Z6R0; D3DUF3 [Other Products]
 UniProt Related Accession #    O15305 [Other Products]
 Molecular Weight    30.2 kDa (266aa), confirmed by MALDI-TOF
Table BarTOPTable Bar
 NCBI Official Full Name    phosphomannomutase 2
 NCBI Official Synonym Full Names    phosphomannomutase 2
 NCBI Official Symbol    PMM2 [Similar Products]
 NCBI Official Synonym Symbols   
PMI; CDG1; CDGS; PMI1; CDG1a; PMM 2
[Similar Products]
 NCBI Protein Information    phosphomannomutase 2
 UniProt Protein Name    Phosphomannomutase 2
 Protein Family    Phosphomannomutase
 UniProt Gene Name    PMM2 [Similar Products]
 UniProt Synonym Gene Names    PMM 2 [Similar Products]
Section Bar
 NCBI Summary for PMM2    The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for PMM2    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.
Table BarTOPTable Bar
 

Product References and Citations for PMM2 recombinant protein

   Matthijs G., et al. (1997) Nat Genet. 16 (1):88-92. ; Vega AI., et al. (2009) Hum Mutat. 30 (5):795-803.;
Section Bar
 Research Articles on PMM2    1. Four patients were diagnosed with PMM2-CDG at the age of 8 years or later as their neurological symptoms were quite mild and they had been able to participate in regular school programs. We report patients with p.Val231Met/p.Arg239Trp and p.Ile120Thr/p.Gly228Cys genotypes which may cause milder variants of PMM2-CDG
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with PMM2 recombinant proteinPathways associated with PMM2 recombinant protein
 Reference Product  PubMed Publications
 MPI recombinant protein  >14 publications with PMM2 and MPI
 ALG6 recombinant protein  >12 publications with PMM2 and ALG6
 PMM1 recombinant protein  >10 publications with PMM2 and PMM1
 HK1 recombinant protein  >2 publications with PMM2 and HK1
 ALG11 recombinant protein  >1 publications with PMM2 and ALG11
 Products by Pathway  Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Amino Sugar And Nucleotide Sugar Metabolism Pathway antibodies  Amino Sugar And Nucleotide Sugar Metabolism Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway antibodies  Biosynthesis Of The N-glycan Precursor (dolichol Lipid-linked Oligosaccharide, LLO) And Transfer To A Nascent Protein Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 GDP-mannose Biosynthesis Pathway antibodies  GDP-mannose Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Diseases associated with PMM2 recombinant proteinOrgans/Tissues associated with PMM2 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >26 publications with PMM2 and Nervous System Diseases
 Congenital disorder of glycosylation type 1A Antibodies  >26 publications with PMM2 and Congenital disorder of glycosylation type 1A
 Atrophy Antibodies  >19 publications with PMM2 and Atrophy
 Brain Diseases Antibodies  >14 publications with PMM2 and Brain Diseases
 Cardiovascular Diseases Antibodies  >10 publications with PMM2 and Cardiovascular Diseases
 Intellectual Disability Antibodies  >9 publications with PMM2 and Intellectual Disability
 Liver Diseases Antibodies  >7 publications with PMM2 and Liver Diseases
 Seizures Antibodies  >7 publications with PMM2 and Seizures
 Edema Antibodies  >6 publications with PMM2 and Edema
 Heart Diseases Antibodies  >6 publications with PMM2 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >30 publications with PMM2 and Brain
 Blood Antibodies  >25 publications with PMM2 and Blood
 Liver Antibodies  >14 publications with PMM2 and Liver
 Eye Antibodies  >10 publications with PMM2 and Eye
 Vascular Antibodies  >7 publications with PMM2 and Vascular
 Kidney Antibodies  >6 publications with PMM2 and Kidney
 Skin Antibodies  >6 publications with PMM2 and Skin
 Connective Tissue Antibodies  >4 publications with PMM2 and Connective Tissue
 Heart Antibodies  >4 publications with PMM2 and Heart
 Embryonic Tissue Antibodies  >3 publications with PMM2 and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions