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PRL-3 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203399
SDS-Page
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
0.5 mg  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PRL-3, Recombinant Protein

 Also Known As   

PRL-3, 1-173aa, Human, His tag, E Coli

 Product Synonym Names    Protein tyrosine phosphatase type IVA 3; PTP4A3; PRL3; Protein tyrosine phosphatase type IVA 3 Potentially prenylated protein tyrosine phosphatase; PRL 3; PRL R; PRLR; Protein tyrosine phosphatase 4a3; PTP 4A3; Protein Tyrosine Phosphatase Type IVA Member 3
 Product Gene Name   

PRL-3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM
 OMIM    AF041434 mRNA
 3D Structure    ModBase 3D Structure for O75365
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 2 mM EDTA, 1 mM DTT, 10% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PRL-3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PRL-3 recombinant protein

   Protein tyrosine phosphatase type IVA 3 (PRL-3), as known as PTP4A3, belongs to a small class of prenylated protein tyrosine phosphatases (PTPs) that remove phosphate modifications from tyrosine residues on proteins. This protein enhances cell proliferation, cell motility and invasive activity. High levels of PRL-3 expression are associated with tumorigenesis and metastasis, thus it is overexpressed in metastatic colorectal, ovarian, liver and skin cancers. Recombinant human PRL-3, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for PRL-3 recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for PRL-3 recombinant protein   

SDS-PAGE

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 SDS-Page of PRL-3 recombinant protein    PRL-3 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PRL-3. It may not necessarily be applicable to this product.
 NCBI GI #    14589856
 NCBI GeneID    11156
 NCBI Accession #    NP_116000 [Other Products]
 NCBI GenBank Nucleotide #    NM_032611.2 [Other Products]
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 UniProt Primary Accession #    O75365 [Other Products]
 UniProt Secondary Accession #    Q8IVN5; Q99849; Q9BTW5 [Other Products]
 UniProt Related Accession #    O75365 [Other Products]
 Molecular Weight    21.6 kDa (193aa), confirmed by MALDI-TOF.
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 NCBI Official Full Name    protein tyrosine phosphatase type IVA 3 isoform 1
 NCBI Official Synonym Full Names    protein tyrosine phosphatase type IVA, member 3
 NCBI Official Symbol    PTP4A3 [Similar Products]
 NCBI Official Synonym Symbols   
PRL3; PRL-3; PRL-R
[Similar Products]
 NCBI Protein Information    protein tyrosine phosphatase type IVA 3
 UniProt Protein Name    Protein tyrosine phosphatase type IVA 3
 UniProt Synonym Protein Names   
PRL-R; Protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; PRL-3
 UniProt Gene Name    PTP4A3 [Similar Products]
 UniProt Synonym Gene Names    PRL3; PRL-3 [Similar Products]
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 NCBI Summary for PRL-3    This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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 UniProt Comments for PRL-3    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
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Product References and Citations for PRL-3 recombinant protein

   Ooki A., et al. (2009). Oncol Rep. 21 (6):1467-75; Wang Z., et al. (2009). Ann Surg Oncol. 16 (1):208-19.;
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 Research Articles on PRL-3    1. Since high PRL-3 expression also correlates with poor prognosis in other cancers and functional studies in PC support these findings, PRL-3 emerges as a potential treatment target in PC
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRL-3 recombinant proteinPathways associated with PRL-3 recombinant protein
 Reference Product  PubMed Publications
 RHOC recombinant protein  >6 publications with PRL-3 and RHOC
 RHOA recombinant protein  >6 publications with PRL-3 and RHOA
 RAC1 recombinant protein  >2 publications with PRL-3 and RAC1
 BCAR1 recombinant protein  >1 publications with PRL-3 and BCAR1
 Products by Pathway  Pathway Diagram
 Signaling Events Mediated By PRL Pathway antibodies  Signaling Events Mediated By PRL Pathway Diagram
Diseases associated with PRL-3 recombinant proteinOrgans/Tissues associated with PRL-3 recombinant protein
 Disease Name  Pubmed Publications
 Liver Neoplasms Antibodies  >99 publications with PRL-3 and Liver Neoplasms
 Neoplasm Invasiveness Antibodies  >54 publications with PRL-3 and Neoplasm Invasiveness
 Colonic Neoplasms Antibodies  >24 publications with PRL-3 and Colonic Neoplasms
 Adenocarcinoma Antibodies  >23 publications with PRL-3 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >19 publications with PRL-3 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >17 publications with PRL-3 and Lung Neoplasms
 Breast Neoplasms Antibodies  >16 publications with PRL-3 and Breast Neoplasms
 Disease Models, Animal Antibodies  >13 publications with PRL-3 and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >11 publications with PRL-3 and Ovarian Neoplasms
 Liver Neoplasms, Experimental Antibodies  >11 publications with PRL-3 and Liver Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >140 publications with PRL-3 and Liver
 Stomach Antibodies  >26 publications with PRL-3 and Stomach
 Lung Antibodies  >19 publications with PRL-3 and Lung
 Blood Antibodies  >13 publications with PRL-3 and Blood
 Intestine Antibodies  >9 publications with PRL-3 and Intestine
 Ovary Antibodies  >7 publications with PRL-3 and Ovary
 Bone Antibodies  >7 publications with PRL-3 and Bone
 Brain Antibodies  >7 publications with PRL-3 and Brain
 Muscle Antibodies  >6 publications with PRL-3 and Muscle
 Prostate Antibodies  >4 publications with PRL-3 and Prostate
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