NP_938074
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
84 kDa (750 aa)
NCBI Official Full Name
protein arginine N-methyltransferase 1 isoform 3
NCBI Official Synonym Full Names
protein arginine methyltransferase 1
NCBI Protein Information
protein arginine N-methyltransferase 1
UniProt Protein Name
Protein arginine N-methyltransferase 1
UniProt Synonym Protein Names
Histone-arginine N-methyltransferase PRMT1; Interferon receptor 1-bound protein 4
UniProt Synonym Gene Names
NCBI Summary for PRMT1
This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]
UniProt Comments for PRMT1
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:16879614). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).
Product References and Citations for PRMT1 active protein
Goulet I., et al. (2007) J Biol Chem. 282 (45):33009-21.; Tang J., et al. (2000) J Biol Chem. 275 (11):7723-30.;
Research Articles on PRMT1
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Products associated with PRMT1 active protein
Pathways associated with PRMT1 active protein
Diseases associated with PRMT1 active protein
Organs/Tissues associated with PRMT1 active protein
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