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PSMA4 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204161
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PSMA4, Recombinant Protein

 Also Known As   

PSMA4, 1-261aa, Human, His tag E Coli

 Product Synonym Names    Proteasome subunit alpha type-4 isoform 1; HC9; HsT17706; MGC111191; MGC12467; MGC24813; PSC9
 Product Gene Name   

PSMA4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSHMSRRYD SRTTIFSPEG RLYQVEYAME AIGHAGTCLG ILANDGVLLA AERRNIHKLL DEVFFSEKIY KLNEDMACSV AGITSDANVL TNELRLIAQR YLLQYQEPIP CEQLVTALCD IKQAYTQFGG KRPFGVSLLY IGWDKHYGFQ LYQSDPSGNY GGWKATCIGN NSAAAVSMLK QDYKEGEMTL KSALALAIKV LNKTMDVSKL SAEKVEIATL TRENGKTVIR VLKQKEVEQL IKKHEEEEAK AEREKKEKEQ KEKDK
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT, 0.1mM PMSF
 Concentration    1.0 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PSMA4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PSMA4 recombinant protein

   PSMA4, also known as proteasome subunit alpha type 4, is a member of the peptidase T1A family, that is a 20S core alpha subunit. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. It is distributed throughout eukaryotic cells at a high concentration and cleaves peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. Recombinant human PSMA4 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
 Product Categories/Family for PSMA4 recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for PSMA4 recombinant protein   

SDS-PAGE

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 SDS-PAGE of PSMA4 recombinant protein    PSMA4 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for PSMA4. It may not necessarily be applicable to this product.
 NCBI GI #    156713442
 NCBI GeneID    5685
 NCBI Accession #    NP_001096137 [Other Products]
 NCBI GenBank Nucleotide #    NM_001102667.1 [Other Products]
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 UniProt Secondary Accession #    Q53XP2; Q567Q5; Q8TBD1; D3DW86 [Other Products]
 UniProt Related Accession #    P25789 [Other Products]
 Molecular Weight    32.0 kDa (285aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    proteasome subunit alpha type-4 isoform 1
 NCBI Official Synonym Full Names    proteasome (prosome, macropain) subunit, alpha type, 4
 NCBI Official Symbol    PSMA4 [Similar Products]
 NCBI Official Synonym Symbols   
HC9; PSC9; HsT17706
[Similar Products]
 NCBI Protein Information    proteasome subunit alpha type-4; macropain subunit C9; multicatalytic endopeptidase complex subunit C9; proteasome component C9; proteasome subunit HC9; proteasome subunit L
 UniProt Protein Name    Proteasome subunit alpha type-4
 UniProt Synonym Protein Names   
Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; Proteasome component C9; Proteasome subunit L
 Protein Family    Proteasome
 UniProt Gene Name    PSMA4 [Similar Products]
 UniProt Synonym Gene Names    HC9; PSC9 [Similar Products]
 UniProt Entry Name    PSA4_HUMAN
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 NCBI Summary for PSMA4    The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PSMA4    PSMA4: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Belongs to the peptidase T1A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Proteasome complex; EC 3.4.25.1; Protease

Chromosomal Location of Human Ortholog: 15q25.1

Cellular Component: nucleoplasm; proteasome complex; proteasome core complex; intracellular membrane-bound organelle; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: threonine endopeptidase activity; protein binding

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
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Product References and Citations for PSMA4 recombinant protein

   Kristensen P. et al. (1995) Biochem. Biophys. Res.Commun. 205: 1785-1789.
Morimoto Y. et al. (1995) J. Biochem. 117: 471-474
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 Research Articles on PSMA4    1. study concludes polymorphisms of TGM5, PPAP2B and PSMA4 are not major contributors tonon-small cell lung cancer susceptibility in never-smoking hinese population, this primarily can be attributed to the significantly distinct genetic background of Asian populations from western populations
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PSMA4 recombinant proteinPathways associated with PSMA4 recombinant protein
 Reference Product  PubMed Publications
 PSMA3 recombinant protein  >4 publications with PSMA4 and PSMA3
 PSMB1 recombinant protein  >2 publications with PSMA4 and PSMB1
 PSMA1 recombinant protein  >2 publications with PSMA4 and PSMA1
 PSMA6 recombinant protein  >2 publications with PSMA4 and PSMA6
 PSMA2 recombinant protein  >2 publications with PSMA4 and PSMA2
 PSMB7 recombinant protein  >1 publications with PSMA4 and PSMB7
 PSMA7 recombinant protein  >1 publications with PSMA4 and PSMA7
 PSMB6 recombinant protein  >1 publications with PSMA4 and PSMB6
 PSMA5 recombinant protein  >1 publications with PSMA4 and PSMA5
 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
Diseases associated with PSMA4 recombinant proteinOrgans/Tissues associated with PSMA4 recombinant protein
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >6 publications with PSMA4 and Lung Neoplasms
 Carcinoma Antibodies  >3 publications with PSMA4 and Carcinoma
 Inflammation Antibodies  >1 publications with PSMA4 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >6 publications with PSMA4 and Lung
 Nerve Antibodies  >5 publications with PSMA4 and Nerve
 Blood Antibodies  >4 publications with PSMA4 and Blood
 Brain Antibodies  >2 publications with PSMA4 and Brain
 Spleen Antibodies  >1 publications with PSMA4 and Spleen
 Vascular Antibodies  >1 publications with PSMA4 and Vascular
 Muscle Antibodies  >1 publications with PSMA4 and Muscle
 Liver Antibodies  >1 publications with PSMA4 and Liver
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