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PSMA4 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204161
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PSMA4, Recombinant Protein

 Also Known As   

PSMA4, 1-261aa, Human, His tag E Coli

 Product Synonym Names    Proteasome subunit alpha type-4 isoform 1; HC9; HsT17706; MGC111191; MGC12467; MGC24813; PSC9
 Product Gene Name   

PSMA4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MGSHMSRRYD SRTTIFSPEG RLYQVEYAME AIGHAGTCLG ILANDGVLLA AERRNIHKLL DEVFFSEKIY KLNEDMACSV AGITSDANVL TNELRLIAQR YLLQYQEPIP CEQLVTALCD IKQAYTQFGG KRPFGVSLLY IGWDKHYGFQ LYQSDPSGNY GGWKATCIGN NSAAAVSMLK QDYKEGEMTL KSALALAIKV LNKTMDVSKL SAEKVEIATL TRENGKTVIR VLKQKEVEQL IKKHEEEEAK AEREKKEKEQ KEKDK
 OMIM    D00763 mRNA
 3D Structure    ModBase 3D Structure for P25789
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol, 1mM DTT, 0.1mM PMSF
 Concentration    1.0 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PSMA4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PSMA4 recombinant protein

   PSMA4, also known as proteasome subunit alpha type 4, is a member of the peptidase T1A family, that is a 20S core alpha subunit. The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. It is distributed throughout eukaryotic cells at a high concentration and cleaves peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. Recombinant human PSMA4 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for PSMA4 recombinant protein    Enzymes & Proteases
 Applications Tested/Suitable for PSMA4 recombinant protein   

SDS-PAGE

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 SDS-Page of PSMA4 recombinant protein    PSMA4 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PSMA4. It may not necessarily be applicable to this product.
 NCBI GI #    156713442
 NCBI GeneID    5685
 NCBI Accession #    NP_001096137 [Other Products]
 NCBI GenBank Nucleotide #    NM_001102667.2 [Other Products]
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 UniProt Primary Accession #    P25789 [Other Products]
 UniProt Secondary Accession #    Q53XP2; Q567Q5; Q8TBD1; D3DW86 [Other Products]
 UniProt Related Accession #    P25789 [Other Products]
 Molecular Weight    32.0 kDa (285aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    proteasome subunit alpha type-4 isoform 1
 NCBI Official Synonym Full Names    proteasome subunit alpha 4
 NCBI Official Symbol    PSMA4 [Similar Products]
 NCBI Official Synonym Symbols   
HC9; PSC9; HsT17706
[Similar Products]
 NCBI Protein Information    proteasome subunit alpha type-4
 UniProt Protein Name    Proteasome subunit alpha type-4
 UniProt Synonym Protein Names   
Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; Proteasome component C9; Proteasome subunit L
 Protein Family    Proteasome
 UniProt Gene Name    PSMA4 [Similar Products]
 UniProt Synonym Gene Names    HC9; PSC9 [Similar Products]
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 NCBI Summary for PSMA4    This gene encodes a core alpha subunit of the 20S proteosome, which is a highly ordered ring-shaped structure composed of four rings of 28 non-identical subunits. Proteasomes cleave peptides in an ATP- and ubiquitin-dependent manner. [provided by RefSeq, Aug 2016]
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 UniProt Comments for PSMA4    Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
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Product References and Citations for PSMA4 recombinant protein

   Kristensen P. et al. (1995) Biochem. Biophys. Res.Commun. 205: 1785-1789.; Morimoto Y. et al. (1995) J. Biochem. 117: 471-474
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 Research Articles on PSMA4    1. rs12901682 is associated with lung cancer risk in a Chinese Han population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PSMA4 recombinant proteinPathways associated with PSMA4 recombinant protein
 Reference Product  PubMed Publications
 PSMA3 recombinant protein  >4 publications with PSMA4 and PSMA3
 PSMB3 recombinant protein  >3 publications with PSMA4 and PSMB3
 PSMB2 recombinant protein  >3 publications with PSMA4 and PSMB2
 PSMA6 recombinant protein  >2 publications with PSMA4 and PSMA6
 PSMA2 recombinant protein  >2 publications with PSMA4 and PSMA2
 PSMA1 recombinant protein  >2 publications with PSMA4 and PSMA1
 PSMB1 recombinant protein  >2 publications with PSMA4 and PSMB1
 PSMB7 recombinant protein  >1 publications with PSMA4 and PSMB7
 PSMA5 recombinant protein  >1 publications with PSMA4 and PSMA5
 Products by Pathway  Pathway Diagram
 ABC Transporter Disorders Pathway antibodies  ABC Transporter Disorders Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Binds And Destabilizes MRNA Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
Diseases associated with PSMA4 recombinant proteinOrgans/Tissues associated with PSMA4 recombinant protein
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >7 publications with PSMA4 and Lung Neoplasms
 Carcinoma Antibodies  >4 publications with PSMA4 and Carcinoma
 Nervous System Diseases Antibodies  >1 publications with PSMA4 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with PSMA4 and Cardiovascular Diseases
 Hypertension Antibodies  >1 publications with PSMA4 and Hypertension
 Inflammation Antibodies  >1 publications with PSMA4 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with PSMA4 and Lung
 Nerve Antibodies  >6 publications with PSMA4 and Nerve
 Blood Antibodies  >5 publications with PSMA4 and Blood
 Brain Antibodies  >3 publications with PSMA4 and Brain
 Mammary Gland Antibodies  >1 publications with PSMA4 and Mammary Gland
 Vascular Antibodies  >1 publications with PSMA4 and Vascular
 Uterus Antibodies  >1 publications with PSMA4 and Uterus
 Muscle Antibodies  >1 publications with PSMA4 and Muscle
 Skin Antibodies  >1 publications with PSMA4 and Skin
 Heart Antibodies  >1 publications with PSMA4 and Heart
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