Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow PSME1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • p63 Antibody
 • GFR alpha-1 Antibody
 • MARCH4 Antibody
 • Mucin-5B (MUC5B) ELISA Kit
 • Centromere Protein B (CENPB) ELISA Kit
 • Activated Protein C Resistance (APCR) ELISA Kit
 • Tartrate Resistant Acid Phosphatase (TRAP) ELISA Kit
 • C4 Binding Protein, Alpha (C4BPA) ELISA Kit
 • Soluble Vascular Cellular Adhesion Molecule 1 (SVCAM-1) ELISA Kit
 • Dystrophin (DMD) ELISA Kit
 • Terminal Complement Complex C5B-9 (TCC C5B-9) ELISA Kit
 • Fibroblast Growth Factor 23 (FGF-23) ELISA Kit
 • Transforming Growth Factor Beta Stimulated Protein Clone 22 ... ELISA Kit
 • Matrix Metalloproteinase 6 (MMP-6) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

PSME1 recombinant protein

Scan QR to view Datasheet Catalog #    MBS203856
SDS-PAGE
Unit / Price
0.05 mg  /  $310 +1 FREE 8GB USB
0.25 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

PSME1, Recombinant Protein

 Also Known As   

PSME1, 1-249aa, Human, His tag, E Coli

 Product Synonym Names    Proteasome activator complex subunit 1; IFI5111; MGC8628; PA28A; PA28alpha; REGalpha
 Product Gene Name   

PSME1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHHHHH SSGLVPRGSH MAMLRVQPEA QAKVDVFRED LCTKTENLLG SYFPKKISEL DAFLKEPALN EANLSNLKAP LDIPVPDPVK EKEKEERKKQ QEKEDKDEKK KGEDEDKGPP CGPVNCNEKI VVLLQRLKPE IKDVIEQLNL VTTWLQLQIP RIEDGNNFGV AVQEKVFELM TSLHTKLEGF HTQISKYFSE RGDAVTKAAK QPHVGDYRQL VHELDEAEYR DIRLMVMEIR NAYAVLYDII LKNFEKLKKP RGETKGMIY
Section Bar
Section Bar
 Purity/Purification    > 90% by SDS - PAGE
 Form/Format    Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
Section Bar
 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
Section Bar
 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PSME1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for PSME1 recombinant protein

   PSME1 is an interferon gamma (IFNG) inducible proteasome activator required for presentation of certain major histocompatibility (MHC) class I antigens. The PSME1 complex is an alternative proteasome activator that does not employ the use of ubiquitin. The PSME1 complex is composed of two homologous subunits, alpha and beta, which have similar catalytic properties and associate to form a hexameric ring. Recombinant human PSME1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for PSME1 recombinant protein    Proteases & Inhibitors
 Applications Tested/Suitable for PSME1 recombinant protein   

SDS-PAGE

Section Bar
 SDS-PAGE of PSME1 recombinant protein    PSME1 recombinant protein SDS-PAGE image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PSME1. It may not necessarily be applicable to this product.
 NCBI GI #    5453990
 NCBI GeneID    5720
 NCBI Accession #    NP_006254 [Other Products]
 NCBI GenBank Nucleotide #    NM_006263.3 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q6IBM2; Q9UEF4; A6NJG9; H0YNE3 [Other Products]
 UniProt Related Accession #    Q06323 [Other Products]
 Molecular Weight    30.8kDa (269aa) confirmed by MALDI-TOF
Table BarTOPTable Bar
 NCBI Official Full Name    proteasome activator complex subunit 1 isoform 1
 NCBI Official Synonym Full Names    proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
 NCBI Official Symbol    PSME1 [Similar Products]
 NCBI Official Synonym Symbols   
PA28A; IFI5111; REGalpha; PA28alpha
[Similar Products]
 NCBI Protein Information    proteasome activator complex subunit 1; 11S regulator complex subunit alpha; 29-kD MCP activator subunit; IGUP I-5111; activator of multicatalytic protease subunit 1; interferon gamma up-regulated I-5111 protein; interferon-gamma IEF SSP 5111; interferon-gamma-inducible protein 5111
 UniProt Protein Name    Proteasome activator complex subunit 1
 UniProt Synonym Protein Names   
11S regulator complex subunit alpha; REG-alpha; Activator of multicatalytic protease subunit 1; Interferon gamma up-regulated I-5111 protein; IGUP I-5111; Proteasome activator 28 subunit alpha; PA28a; PA28alpha
 Protein Family    Proteasome activator complex
 UniProt Gene Name    PSME1 [Similar Products]
 UniProt Synonym Gene Names    IFI5111; REG-alpha; IGUP I-5111; PA28a; PA28alpha [Similar Products]
 UniProt Entry Name    PSME1_HUMAN
Section Bar
 NCBI Summary for PSME1    The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Section Bar
 UniProt Comments for PSME1    PSME1: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. Heterodimer of PSME1 and PSME2, which forms a hexadimeric ring. PSME1 can form homoheptamers. By IFNG/IFN-gamma. Belongs to the PA28 family.

Protein type: Proteasome complex

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: nucleoplasm; proteasome complex; proteasome activator complex; cytoplasm; cytosol

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
Table BarTOPTable Bar
 

Product References and Citations for PSME1 recombinant protein

   Ahn K.. et al. (1996) J Biol Chem. 271(30):18237-42
Murata S.,et al. (2001) EMBO J.. 20(21):5898-907.
Section Bar
 Research Articles on PSME1    1. PA28 is a tumor marker and a potential target for therapeutic intervention in prostate cancer.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with PSME1 recombinant proteinPathways associated with PSME1 recombinant protein
 Reference Product  PubMed Publications
 PSME2 recombinant protein  >54 publications with PSME1 and PSME2
 PSMB10 recombinant protein  >12 publications with PSME1 and PSMB10
 PSMB2 recombinant protein  >2 publications with PSME1 and PSMB2
 PSMB5 recombinant protein  >2 publications with PSME1 and PSMB5
 PSMA6 recombinant protein  >1 publications with PSME1 and PSMA6
 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
Diseases associated with PSME1 recombinant proteinOrgans/Tissues associated with PSME1 recombinant protein
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >10 publications with PSME1 and Immune System Diseases
 Carcinoma Antibodies  >10 publications with PSME1 and Carcinoma
 Nervous System Diseases Antibodies  >7 publications with PSME1 and Nervous System Diseases
 Liver Diseases Antibodies  >6 publications with PSME1 and Liver Diseases
 Inflammation Antibodies  >6 publications with PSME1 and Inflammation
 Brain Diseases Antibodies  >5 publications with PSME1 and Brain Diseases
 Death Antibodies  >5 publications with PSME1 and Death
 Necrosis Antibodies  >4 publications with PSME1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >3 publications with PSME1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with PSME1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >108 publications with PSME1 and Muscle
 Blood Antibodies  >47 publications with PSME1 and Blood
 Liver Antibodies  >11 publications with PSME1 and Liver
 Brain Antibodies  >9 publications with PSME1 and Brain
 Vascular Antibodies  >5 publications with PSME1 and Vascular
 Heart Antibodies  >4 publications with PSME1 and Heart
 Spleen Antibodies  >4 publications with PSME1 and Spleen
 Kidney Antibodies  >4 publications with PSME1 and Kidney
 Skin Antibodies  >4 publications with PSME1 and Skin
 Lung Antibodies  >4 publications with PSME1 and Lung
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions