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PANK2 recombinant protein :: Pantothenate kinase 2, mitochondrial (PANK2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1354693 PANK2 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $950 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,145 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,270 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,380 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,395 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,400 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,455 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,560 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,990 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,085 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,105 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,375 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,735 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pantothenate kinase 2, mitochondrial (PANK2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Pantothenate kinase 2, mitochondrial (PANK2)

 Product Gene Name   

PANK2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    PANK2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    47-570aa, Full Length of Mature Protein
 Sequence    SLSLDGGTVN PPRVREPTGR EAFGPSPASS DWLPARWRNG RGGRPRARLC SGWTAAEEAR RNPTLGGLLG RQRLLLRMGG GRLGAPMERH GRASATSVSS AGEQAAGDPE GRRQEPLRRR ASSASVPAVG ASAEGTRRDR LGSYSGPTSV SRQRVESLRK KRPLFPWFGL DIGGTLVKLV YFEPKDITAE EEEEEVESLK SIRKYLTSNV AYGSTGIRDV HLELKDLTLC GRKGNLHFIR FPTHDMPAFI QMGRDKNFSS LHTVFCATGG GAYKFEQDFL TIGDLQLCKL DELDCLIKGI LYIDSVGFNG RSQCYYFENP ADSEKCQKLP FDLKNPYPLL LVNIGSGVSI LAVYSKDNYK RVTGTSLGGG TFFGLCCLLT GCTTFEEALE MASRGDSTKV DKLVRDIYGG DYERFGLPGW AVASSFGNMM SKEKREAVSK EDLARATLIT ITNNIGSIAR MCALNENINQ VVFVGNFLRI NTIAMRLLAY ALDYWSKGQL KALFSEHEGY FGAVGALLEL LKIP
 OMIM    234200
 3D Structure    ModBase 3D Structure for Q9BZ23
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PANK2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PANK2 recombinant protein

   This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.
NCBI/Uniprot data below describe general gene information for PANK2. It may not necessarily be applicable to this product.
 NCBI GI #    1023300911
 NCBI GeneID    80025
 NCBI Accession #    NP_001311120.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001324191.1 [Other Products]
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 UniProt Primary Accession #    Q9BZ23 [Other Products]
 UniProt Secondary Accession #    Q5T7I2; Q5T7I4; Q7RTX5; Q8N7Q4; Q8TCR5; Q9BYW5; Q9HAF2; B1AK33; B2Z3X0; D3DVZ0 [Other Products]
 UniProt Related Accession #    Q9BZ23 [Other Products]
 Molecular Weight    50,582 Da
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 NCBI Official Full Name    pantothenate kinase 2, mitochondrial isoform 2
 NCBI Official Synonym Full Names    pantothenate kinase 2
 NCBI Official Symbol    PANK2 [Similar Products]
 NCBI Official Synonym Symbols   
HSS; HARP; PKAN; NBIA1; C20orf48
[Similar Products]
 NCBI Protein Information    pantothenate kinase 2, mitochondrial
 UniProt Protein Name    Pantothenate kinase 2, mitochondrial
 UniProt Synonym Protein Names   
Pantothenic acid kinase 2
 Protein Family    Pantothenate kinase
 UniProt Gene Name    PANK2 [Similar Products]
 UniProt Synonym Gene Names    C20orf48; hPanK2 [Similar Products]
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 NCBI Summary for PANK2    This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PANK2    May be the master regulator of the CoA biosynthesis.
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 Research Articles on PANK2    1. PANK2 mutations have an effect on iPSC-derived cortical neuronal cells in culture
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PANK2 recombinant proteinPathways associated with PANK2 recombinant protein
 Reference Product  PubMed Publications
 PLA2G6 recombinant protein  >27 publications with PANK2 and PLA2G6
 COASY recombinant protein  >8 publications with PANK2 and COASY
 FA2H recombinant protein  >7 publications with PANK2 and FA2H
 ATP13A2 recombinant protein  >6 publications with PANK2 and ATP13A2
 FTL recombinant protein  >4 publications with PANK2 and FTL
 Products by Pathway  Pathway Diagram
 Coenzyme A Biosynthesis Pathway antibodies  Coenzyme A Biosynthesis Pathway Diagram
 Coenzyme A Biosynthesis, Pantothenate => CoA Pathway antibodies  Coenzyme A Biosynthesis, Pantothenate => CoA Pathway Diagram
 Coenzyme A Biosynthesis, Pantothenate => CoA Pathway antibodies  Coenzyme A Biosynthesis, Pantothenate => CoA Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Vitamin B5 (pantothenate) Metabolism Pathway antibodies  Vitamin B5 (pantothenate) Metabolism Pathway Diagram
Diseases associated with PANK2 recombinant proteinOrgans/Tissues associated with PANK2 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >132 publications with PANK2 and Nervous System Diseases
 Pantothenate Kinase-Associated Neurodegeneration Antibodies  >130 publications with PANK2 and Pantothenate Kinase-Associated Neurodegeneration
 Neurodegenerative Diseases Antibodies  >119 publications with PANK2 and Neurodegenerative Diseases
 Neurodegeneration with brain iron accumulation (NBIA) Antibodies  >43 publications with PANK2 and Neurodegeneration with brain iron accumulation (NBIA)
 Nerve Degeneration Antibodies  >12 publications with PANK2 and Nerve Degeneration
 Disease Models, Animal Antibodies  >11 publications with PANK2 and Disease Models, Animal
 Hypoprebetalipoproteinemia, Acanthocytosis, Retinitis Pigmentosa, And Pallidal Degeneration Antibodies  >3 publications with PANK2 and Hypoprebetalipoproteinemia, Acanthocytosis, Retinitis Pigmentosa, And Pallidal Degeneration
 Dyslipidemias Antibodies  >3 publications with PANK2 and Dyslipidemias
 Congenital Abnormalities Antibodies  >2 publications with PANK2 and Congenital Abnormalities
 Pain Antibodies  >2 publications with PANK2 and Pain
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >116 publications with PANK2 and Brain
 Blood Antibodies  >15 publications with PANK2 and Blood
 Skin Antibodies  >3 publications with PANK2 and Skin
 Mouth Antibodies  >2 publications with PANK2 and Mouth
 Bone Antibodies  >1 publications with PANK2 and Bone
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