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PANK2 recombinant protein :: Pantothenate kinase 2, mitochondrial (PANK2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1354693 PANK2 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $950 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,015 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,145 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,270 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,380 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,395 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,400 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,455 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,560 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,990 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,085 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,105 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,375 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,735 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pantothenate kinase 2, mitochondrial (PANK2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Pantothenate kinase 2, mitochondrial (PANK2)

 Product Synonym Names    Pantothenate kinase 2, mitochondrial; hPanK2; EC=2.7.1.33; Pantothenic acid kinase 2
 Product Gene Name   

PANK2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    PANK2; C20orf48 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    47-570aa; full length protein
 Sequence    SLSL DGGTVNPPRV REPTGREAFG PSPASSDWLP ARWRNGRGGR PRARLCSGWT AAEEARRNPT LGGLLGRQRL LLRMGGGRLG APMERHGRAS ATSVSSAGEQ AAGDPEGRRQ EPLRRRASSA SVPAVGASAE GTRRDRLGSY SGPTSVSRQR VESLRKKRPL FPWFGLDIGG TLVKLVYFEP KDITAEEEEE EVESLKSIRK YLTSNVAYGS TGIRDVHLEL KDLTLCGRKG NLHFIRFPTH DMPAFIQMGR DKNFSSLHTV FCATGGGAYK FEQDFLTIGD LQLCKLDELD CLIKGILYID SVGFNGRSQC YYFENPADSE KCQKLPFDLK NPYPLLLVNI GSGVSILAVY SKDNYKRVTG TSLGGGTFFG LCCLLTGCTT FEEALEMASR GDSTKVDKLV RDIYGGDYER FGLPGWAVAS SFGNMMSKEK REAVSKEDLA RATLITITNN IGSIARMCAL NENINQVVFV GNFLRINTIA MRLLAYALDY WSKGQLKALF SEHEGYFGAV GALLELLKIP
 OMIM    gene 607236
 3D Structure    ModBase 3D Structure for Q9BZ23
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PANK2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for PANK2 recombinant protein

   This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.
NCBI/Uniprot data below describe general gene information for PANK2. It may not necessarily be applicable to this product.
 NCBI GI #    24430167
 NCBI GeneID    80025
 NCBI Accession #    NP_079236.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_024960.4 [Other Products]
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 UniProt Primary Accession #    Q9BZ23 [Other Products]
 UniProt Secondary Accession #    Q5T7I2; Q5T7I4; Q7RTX5; Q8N7Q4; Q8TCR5; Q9BYW5; Q9HAF2; B1AK33; B2Z3X0; D3DVZ0 [Other Products]
 UniProt Related Accession #    Q9BZ23 [Other Products]
 Molecular Weight    50,582 Da
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 NCBI Official Full Name    pantothenate kinase 2, mitochondrial isoform 2
 NCBI Official Synonym Full Names    pantothenate kinase 2
 NCBI Official Symbol    PANK2 [Similar Products]
 NCBI Official Synonym Symbols   
HSS; HARP; PKAN; NBIA1; C20orf48
[Similar Products]
 NCBI Protein Information    pantothenate kinase 2, mitochondrial; pantothenic acid kinase 2; Hallervorden-Spatz syndrome
 UniProt Protein Name    Pantothenate kinase 2, mitochondrial
 UniProt Synonym Protein Names   
Pantothenic acid kinase 2
 Protein Family    Pantothenate kinase
 UniProt Gene Name    PANK2 [Similar Products]
 UniProt Synonym Gene Names    C20orf48; hPanK2 [Similar Products]
 UniProt Entry Name    PANK2_HUMAN
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 NCBI Summary for PANK2    This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PANK2    PANK2: a pantothenate kinase that catalyzes the first committed step in the biosynthesis of coenzyme A, an essential cofactor in cellular metabolism. PANK2 is predominantly localized in mitochondria in primates. Defects in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Three isoforms of the human PANK2, produced by alternative splicing, have been reported.

Protein type: EC 2.7.1.33; Mitochondrial; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Kinase, other

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: mitochondrial intermembrane space; cytosol

Molecular Function: pantothenate kinase activity; ATP binding

Biological Process: coenzyme biosynthetic process; coenzyme A biosynthetic process; vitamin metabolic process; regulation of mitochondrial membrane potential; pantothenate metabolic process; aerobic respiration; phosphorylation; water-soluble vitamin metabolic process; spermatid development

Disease: Hypoprebetalipoproteinemia, Acanthocytosis, Retinitis Pigmentosa, And Pallidal Degeneration; Neurodegeneration With Brain Iron Accumulation 1
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 Research Articles on PANK2    1. Caucasian patients have more complex presentations than Asians. Exon 3 and 4 are hot spots for screening PANK2 mutations in Asian patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PANK2 recombinant proteinDiseases associated with PANK2 recombinant protein
 Products by Pathway  Pathway Diagram
 Coenzyme A Biosynthesis Pathway antibodies  Coenzyme A Biosynthesis Pathway Diagram
 Coenzyme A Biosynthesis, Pantothenate => CoA Pathway antibodies  Coenzyme A Biosynthesis, Pantothenate => CoA Pathway Diagram
 Coenzyme A Biosynthesis, Pantothenate => CoA Pathway antibodies  Coenzyme A Biosynthesis, Pantothenate => CoA Pathway Diagram
 Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective BTD Causes Biotidinase Deficiency Pathway antibodies  Defective BTD Causes Biotidinase Deficiency Pathway Diagram
 Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies  Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
 Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies  Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
 Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies  Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
 Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies  Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
 Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies  Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >114 publications with PANK2 and Nervous System Diseases
 Pantothenate Kinase-Associated Neurodegeneration Antibodies  >112 publications with PANK2 and Pantothenate Kinase-Associated Neurodegeneration
 Neurodegenerative Diseases Antibodies  >101 publications with PANK2 and Neurodegenerative Diseases
 Neurodegeneration with brain iron accumulation (NBIA) Antibodies  >35 publications with PANK2 and Neurodegeneration with brain iron accumulation (NBIA)
 Nerve Degeneration Antibodies  >12 publications with PANK2 and Nerve Degeneration
 Tremor Antibodies  >8 publications with PANK2 and Tremor
 Atrophy Antibodies  >8 publications with PANK2 and Atrophy
 Retinal Degeneration Antibodies  >8 publications with PANK2 and Retinal Degeneration
 Hypoprebetalipoproteinemia, Acanthocytosis, Retinitis Pigmentosa, And Pallidal Degeneration Antibodies  >3 publications with PANK2 and Hypoprebetalipoproteinemia, Acanthocytosis, Retinitis Pigmentosa, And Pallidal Degeneration
 Kidney Diseases Antibodies  >1 publications with PANK2 and Kidney Diseases
Organs/Tissues associated with PANK2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >99 publications with PANK2 and Brain
 Eye Antibodies  >41 publications with PANK2 and Eye
 Ganglia Antibodies  >35 publications with PANK2 and Ganglia
 Blood Antibodies  >12 publications with PANK2 and Blood
 Muscle Antibodies  >5 publications with PANK2 and Muscle
 Liver Antibodies  >3 publications with PANK2 and Liver
 Skin Antibodies  >2 publications with PANK2 and Skin
 Mouth Antibodies  >1 publications with PANK2 and Mouth
 Kidney Antibodies  >1 publications with PANK2 and Kidney
 Pancreas Antibodies  >1 publications with PANK2 and Pancreas
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