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PON3 recombinant protein :: Paraoxonase 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2030563
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $260 +1 FREE 8GB USB
0.1 mg  /  $400 +1 FREE 8GB USB
0.2 mg  /  $495 +1 FREE 8GB USB
0.5 mg  /  $955 +1 FREE 8GB USB
1 mg  /  $1,415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Paraoxonase 3 (PON3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Paraoxonase 3 (PON3)

 Product Gene Name   

PON3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602720
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 Host    E.coli
 Species Reactivity    Human
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 Purity/Purification    >98%
 Form/Format    100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
 Concentration    Original Concentration: 200g/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Gly2~Leu354
 Tags    N-terminal His-Tag
 Tissue Specificity    Liver
  Traits    Freeze-dried powder
 Subcellular Location    Secreted
 Predicted isoelectric point    5.2
 Predicted Molecular Mass    43.2kDa
 Accurate Molecular Mass    43kDa as determined by SDS-PAGE reducing conditions
 Usage    Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 24 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of PON3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for PON3 recombinant protein   

Positive Control, Immunogen, SDS-PAGE, WB
(May be suitable for use in other assays to be determined by the end user.)

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 Squence of PON3 recombinant protein    PON3 recombinant protein Squence image
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 SDS-Page of PON3 recombinant protein    PON3 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PON3. It may not necessarily be applicable to this product.
 NCBI GI #    51094887
 NCBI GeneID    5446
 NCBI Accession #    EAL24132.1 [Other Products]
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 UniProt Secondary Accession #    O75855; O76060; Q6IRU9; Q8IX97; Q9BZH9; A4D1H8 [Other Products]
 UniProt Related Accession #    Q15166 [Other Products]
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 NCBI Official Full Name    paraoxonase 3
 NCBI Official Synonym Full Names    paraoxonase 3
 NCBI Official Symbol    PON3 [Similar Products]
 NCBI Protein Information    serum paraoxonase/lactonase 3
 UniProt Protein Name    Serum paraoxonase/lactonase 3
 Protein Family    Serum paraoxonase/lactonase
 UniProt Gene Name    PON3 [Similar Products]
 UniProt Entry Name    PON3_HUMAN
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 NCBI Summary for PON3    This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PON3    PON3: Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents. Belongs to the paraoxonase family.

Protein type: EC 3.1.1.81; EC 3.1.1.2; Secreted, signal peptide; Hydrolase; EC 3.1.8.1; Secreted

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: extracellular space; intracellular membrane-bound organelle

Molecular Function: protein homodimerization activity; 3,4-dihydrocoumarin hydrolase activity; arylesterase activity; dihydrocoumarin hydrolase activity; metal ion binding; aryldialkylphosphatase activity

Biological Process: response to external stimulus; dephosphorylation; coumarin catabolic process; carboxylic acid catabolic process; aromatic compound catabolic process; phenylacetate catabolic process
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 Research Articles on PON3    1. PON2 and PON3 (i) are associated with mitochondria and mitochondria-associated membranes, (ii) modulate mitochondria-dependent superoxide production, and (iii) prevent apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PON3 recombinant proteinPathways associated with PON3 recombinant protein
 Reference Product  PubMed Publications
 APOE recombinant protein  >9 publications with PON3 and APOE
 ASB4 recombinant protein  >1 publications with PON3 and ASB4
 APOA1 recombinant protein  >1 publications with PON3 and APOA1
 LDLR recombinant protein  >1 publications with PON3 and LDLR
 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Phase I, Non P450 Pathway antibodies  Phase I, Non P450 Pathway Diagram
Diseases associated with PON3 recombinant proteinOrgans/Tissues associated with PON3 recombinant protein
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >54 publications with PON3 and Atherosclerosis
 Heart Diseases Antibodies  >19 publications with PON3 and Heart Diseases
 Nervous System Diseases Antibodies  >18 publications with PON3 and Nervous System Diseases
 Inflammation Antibodies  >16 publications with PON3 and Inflammation
 Liver Diseases Antibodies  >10 publications with PON3 and Liver Diseases
 Fatty Liver Antibodies  >6 publications with PON3 and Fatty Liver
 Poisoning Antibodies  >4 publications with PON3 and Poisoning
 Kidney Diseases Antibodies  >3 publications with PON3 and Kidney Diseases
 Necrosis Antibodies  >3 publications with PON3 and Necrosis
 Drug-Related Side Effects and Adverse Reactions Antibodies  >2 publications with PON3 and Drug-Related Side Effects and Adverse Reactions
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >44 publications with PON3 and Liver
 Lung Antibodies  >11 publications with PON3 and Lung
 Intestine Antibodies  >7 publications with PON3 and Intestine
 Kidney Antibodies  >5 publications with PON3 and Kidney
 Brain Antibodies  >5 publications with PON3 and Brain
 Trachea Antibodies  >2 publications with PON3 and Trachea
 Pancreas Antibodies  >2 publications with PON3 and Pancreas
 Embryonic Tissue Antibodies  >2 publications with PON3 and Embryonic Tissue
 Stomach Antibodies  >1 publications with PON3 and Stomach
 Connective Tissue Antibodies  >1 publications with PON3 and Connective Tissue
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