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PTH recombinant protein :: Parathyroid Hormone Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203075
SDS-Page
Unit / Price
0.1 mg  /  $255 +1 FREE 8GB USB
0.5 mg  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Parathyroid Hormone (PTH), Recombinant Protein

★Popular Item★
 Also Known As   

Parathyroid Hormone, 32-115 aa, Human, E Coli

 Product Synonym Names    PTH; Human Parathyroid Hormone; PTH; Parathyrin; Parathormone; Parathyroid hormone; hPTH; Parathormone
 Product Gene Name   

PTH recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSVSEIQLMH NLGKHLNSME RVEWLRKKLQ DVHNFVALGA PLAPRDAGSQ RPRKKEDNVL VESHEKSLGE ADKADVNVLT KAKSQ
 OMIM    V00597 mRNA
 3D Structure    ModBase 3D Structure for P01270
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) containing 2mM EDTA
 Concentration    1 mg/ml (determined by Absorbance at 280nm) (lot specific)
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 Antigen Species    Human
 Endotoxin Level    < 1.0 EU per 1 microgram of protein (determined by LAL method)
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PTH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PTH recombinant protein

   Human parathyroid hormone (hPTH) is an 84 amino acid residue peptide and one of the main regulators in maintenance of calcium homeostasis. It acts primarily on kidney and bone cells stimulating calcium back resorption or calcium mobilization, respectively. The whole mechanism is still under discussion, but low-dose hPTH triggers cyclic AMP-dependent protein kinase in some populations of bone cells bearing PTH receptors, which stimulates the proliferation of osteoblasts. Human parathyroid hormone (amino acids 1-84) was overexpressed in E. coli and purified to apparent homogeneity by using conventional column chromatography techniques
 Product Categories/Family for PTH recombinant protein    Hormones & Cytokines
 Applications Tested/Suitable for PTH recombinant protein   

SDS-PAGE

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 SDS-Page of PTH recombinant protein    PTH recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PTH. It may not necessarily be applicable to this product.
 NCBI GI #    4506267
 NCBI GeneID    5741
 NCBI Accession #    NP_000306 [Other Products]
 NCBI GenBank Nucleotide #    NM_000315.3 [Other Products]
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 UniProt Primary Accession #    P01270 [Other Products]
 UniProt Secondary Accession #    Q4VB48; Q9UD38 [Other Products]
 UniProt Related Accession #    P01270 [Other Products]
 Molecular Weight    9.55 kDa (85 aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    parathyroid hormone isoform 1 preproprotein
 NCBI Official Synonym Full Names    parathyroid hormone
 NCBI Official Symbol    PTH [Similar Products]
 NCBI Official Synonym Symbols   
PTH1
[Similar Products]
 NCBI Protein Information    parathyroid hormone
 UniProt Protein Name    Parathyroid hormone
 UniProt Synonym Protein Names   
Parathormone; Parathyrin
 Protein Family    Parathyroid hormone
 UniProt Gene Name    PTH [Similar Products]
 UniProt Synonym Gene Names    PTH [Similar Products]
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 NCBI Summary for PTH    This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
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 UniProt Comments for PTH    PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
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Product References and Citations for PTH recombinant protein

   Hodsman AB. et al. (2003) J. Clin. Endocrinol. Metab. 88 (11), 5212-20.; Wingender E., et al. (1989) J. Biol. Chem. 264 (8),4367-73.;
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 Research Articles on PTH    1. Patients with chronic kidney disease undergoing parathyroidectomy for primary hyperparathyroidism have similar intraoperative parathyroid hormone degradation kinetics to those with normal kidney function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PTH recombinant proteinPathways associated with PTH recombinant protein
 Reference Product  PubMed Publications
 PTHLH recombinant protein  >454 publications with PTH and PTHLH
 PTH1R recombinant protein  >257 publications with PTH and PTH1R
 AVP recombinant protein  >62 publications with PTH and AVP
 SCT recombinant protein  >37 publications with PTH and SCT
 PTH2R recombinant protein  >19 publications with PTH and PTH2R
 CALCA recombinant protein  >10 publications with PTH and CALCA
 GCG recombinant protein  >1 publications with PTH and GCG
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Vitamin D Metabolism Pathway antibodies  Vitamin D Metabolism Pathway Diagram
Diseases associated with PTH recombinant proteinOrgans/Tissues associated with PTH recombinant protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3817 publications with PTH and Kidney Diseases
 Hyperparathyroidism, Secondary Antibodies  >3175 publications with PTH and Hyperparathyroidism, Secondary
 Hypercalcemia Antibodies  >2691 publications with PTH and Hypercalcemia
 Renal Insufficiency Antibodies  >2519 publications with PTH and Renal Insufficiency
 Osteoporosis Antibodies  >2448 publications with PTH and Osteoporosis
 Bone Resorption Antibodies  >2430 publications with PTH and Bone Resorption
 Hypocalcemia Antibodies  >1632 publications with PTH and Hypocalcemia
 Cardiovascular Diseases Antibodies  >1133 publications with PTH and Cardiovascular Diseases
 Fractures, Bone Antibodies  >1035 publications with PTH and Fractures, Bone
 Rickets Antibodies  >880 publications with PTH and Rickets
 Organ/Tissue Name  Pubmed Publications
 Parathyroid Antibodies  >17433 publications with PTH and Parathyroid
 Connective Tissue Antibodies  >2648 publications with PTH and Connective Tissue
 Embryonic Tissue Antibodies  >248 publications with PTH and Embryonic Tissue
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