NP_001296445.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29.6 kDa
NCBI Official Full Name
parathyroid hormone 2 receptor isoform 2
NCBI Official Synonym Full Names
parathyroid hormone 2 receptor
NCBI Official Synonym Symbols
NCBI Protein Information
parathyroid hormone 2 receptor
UniProt Protein Name
Parathyroid hormone 2 receptor
UniProt Synonym Gene Names
UniProt Entry Name
PTH2R_HUMAN
NCBI Summary for PTH2R
The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
UniProt Comments for PTH2R
PTH2R: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor. Belongs to the G-protein coupled receptor 2 family.
Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2q33
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: parathyroid hormone receptor activity; protein binding
Biological Process: cell surface receptor linked signal transduction; G-protein coupled receptor protein signaling pathway
Product References and Citations for PTH2R recombinant protein
Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.Usdin T.B., Gruber C., Bonner T.I.J. Biol. Chem. 270:15455-15458(1995)
cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)
.King M.M., Aronstam R.S., Sharma S.V.
Assignment of the human PTH2 receptor gene (PTHR2)
to chromosome 2q33 by fluorescence in situ hybridization.Usdin T.B., Modi W., Bonner T.I.Genomics 37:140-141(1996)
Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.Endocrinology 143:1047-1057(2002)
Research Articles on PTH2R
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with PTH2R recombinant protein
Diseases associated with PTH2R recombinant protein
Organs/Tissues associated with PTH2R recombinant protein
|