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PTH2R recombinant protein :: Parathyroid hormone 2 receptor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS949987
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Parathyroid hormone 2 receptor (PTH2R), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Parathyroid hormone 2 receptor

 Product Gene Name   

PTH2R recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    27-145aa; Extracellular Domain
 Sequence    DSDGTITIEE QIVLVLKAKV QCELNITAQL QEGEGNCFPE WDGLICWPRG TVGKISAVPC PPYIYDFNHK GVAFRHCNPN GTWDFMHSLN KTWANYSDCL RFLQPDISIG KQEFFERLY
 OMIM    601469
 3D Structure    ModBase 3D Structure for P49190
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PTH2R recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PTH2R recombinant protein

   This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.
 Product Categories/Family for PTH2R recombinant protein    Neuroscience
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 SDS-PAGE of PTH2R recombinant protein    PTH2R recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PTH2R. It may not necessarily be applicable to this product.
 NCBI GI #    828747943
 NCBI GeneID    5746
 NCBI Accession #    NP_001296445.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001309516.1 [Other Products]
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 UniProt Primary Accession #    P49190 [Other Products]
 UniProt Secondary Accession #    Q8N429 [Other Products]
 UniProt Related Accession #    P49190 [Other Products]
 Molecular Weight    29.6kD
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 NCBI Official Full Name    parathyroid hormone 2 receptor isoform 2
 NCBI Official Synonym Full Names    parathyroid hormone 2 receptor
 NCBI Official Symbol    PTH2R [Similar Products]
 NCBI Official Synonym Symbols   
PTHR2
[Similar Products]
 NCBI Protein Information    parathyroid hormone 2 receptor
 UniProt Protein Name    Parathyroid hormone 2 receptor
 Protein Family    Parathyroid hormone 2 receptor
 UniProt Gene Name    PTH2R [Similar Products]
 UniProt Synonym Gene Names    PTHR2; PTH2 receptor [Similar Products]
 UniProt Entry Name    PTH2R_HUMAN
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 NCBI Summary for PTH2R    The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
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 UniProt Comments for PTH2R    PTH2R: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor. Belongs to the G-protein coupled receptor 2 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: parathyroid hormone receptor activity; protein binding

Biological Process: cell surface receptor linked signal transduction; G-protein coupled receptor protein signaling pathway
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Product References and Citations for PTH2R recombinant protein

   Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.Usdin T.B., Gruber C., Bonner T.I.J. Biol. Chem. 270:15455-15458(1995) cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org) .King M.M., Aronstam R.S., Sharma S.V. Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.Usdin T.B., Modi W., Bonner T.I.Genomics 37:140-141(1996) Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.John M.R., Arai M., Rubin D.A., Jonsson K.B., Jueppner H.Endocrinology 143:1047-1057(2002)
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 Research Articles on PTH2R    1. Variation in the PTH2R gene (Chr2q34, rs897083) may contribute to the age-associated degenerative manifestations that develop at the lumbar spine
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PTH2R recombinant proteinDiseases associated with PTH2R recombinant protein
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Disease Name  Pubmed Publications
 Seizures Antibodies  >1 publications with PTH2R and Seizures
 Brain Diseases Antibodies  >1 publications with PTH2R and Brain Diseases
 Inflammation Antibodies  >1 publications with PTH2R and Inflammation
 Learning Disorders Antibodies  >1 publications with PTH2R and Learning Disorders
Organs/Tissues associated with PTH2R recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with PTH2R and Brain
 Lung Antibodies  >1 publications with PTH2R and Lung
 Testis Antibodies  >1 publications with PTH2R and Testis
 Bone Marrow Antibodies  >1 publications with PTH2R and Bone Marrow
 Skin Antibodies  >1 publications with PTH2R and Skin
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