NP_002811.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19.7 kDa
NCBI Official Full Name
parathyroid hormone-related protein isoform 2 preproprotein
NCBI Official Synonym Full Names
parathyroid hormone-like hormone
NCBI Protein Information
parathyroid hormone-related protein
UniProt Protein Name
Parathyroid hormone-related protein
UniProt Synonym Protein Names
Parathyroid hormone-like protein; PLP
UniProt Synonym Gene Names
UniProt Entry Name
PTHR_HUMAN
NCBI Summary for PTHLH
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]
UniProt Comments for PTHLH
PTHrP: a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Three alternatively spliced isoforms have been described.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 12p12.1-p11.2
Cellular Component: cytoplasm; extracellular region; extracellular space; Golgi apparatus; nucleoplasm
Molecular Function: hormone activity; peptide hormone receptor binding
Biological Process: alveolus development; cAMP metabolic process; cell-cell signaling; endochondral ossification; endoderm development; epidermis development; epithelial cell differentiation; female pregnancy; G-protein signaling, adenylate cyclase activating pathway; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of transcription factor activity; osteoblast development; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; protein processing; regulation of gene expression; skeletal development; surfactant homeostasis
Disease: Brachydactyly, Type E2
Product References and Citations for PTHLH recombinant protein
A parathyroid hormone-related protein implicated in malignant hypercalcemia
cloning and expression.Suva L.J., Winslow G.A., Wettenhall R.E.H., Hammonds R.G., Moseley J.M., Diefenbach-Jagger H., Rodda C.P., Kemp B.E., Rodriguez H., Chen E.Y., Hudson P.J., Martin T.J., Wood W.I.Science 237:893-896(1987)
Research Articles on PTHLH
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Products associated with PTHLH recombinant protein
Pathways associated with PTHLH recombinant protein
Diseases associated with PTHLH recombinant protein
Organs/Tissues associated with PTHLH recombinant protein
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