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PARK7 recombinant protein :: Parkinson Disease Protein 7 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143125 PARK7 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,940 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Parkinson Disease Protein 7 (PARK7), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Parkinson Disease Protein 7

 Product Synonym Names    Protein DJ-1, Oncogene DJ1, Parkinson disease protein 7, PARK7, DJ1, DJ-1, FLJ27376.
 Product Gene Name   

PARK7 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHH HHH GMASMTGGQQ MGRDLYDDDD KDRWGS MASK RALVILAKGA EEMETVIPVD VMRRAGIKVT VAGLAGKDPV QCSRDVVICP DASLEDAKKE GPYDVVVLPG GNLGAQNLSE SAAVKEILKE QENRKGLIAA ICAGPTALLA HEIGFGSKVT THPLAKDKMM NGGHYTYSEN RVEKDGLILT SRGPGTSFEF ALAIVEALNG KEVAAQVKAP LVLKD
 OMIM    168600
 3D Structure    ModBase 3D Structure for Q99497
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The protein solution (1mg/ml) contains 20mM Tris-HCl pH-8 and 20% glycerol.
Sterile Filtered colorless solution.
 Concentration    1mg/ml (lot specific)
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 Preparation and Storage    Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles
 Other Notes    Small volumes of PARK7 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PARK7 recombinant protein

   Description: PARK7 Human Recombinant fused to an N-terminal 36 aa His-Tag, produced in E Coli is a single, non-glycosylated polypeptide chain (aa 1-189) containing 225 amino acids and having a molecular mass of 24 kDa.

Introduction: The PARK7 is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signaling and oxidative stress. Mutations in the PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7 (Park7).
 Product Categories/Family for PARK7 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for PARK7. It may not necessarily be applicable to this product.
 NCBI GI #    183227678
 NCBI GeneID    11315
 NCBI Accession #    NP_001116849.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001123377.1 [Other Products]
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 UniProt Primary Accession #    Q99497 [Other Products]
 UniProt Secondary Accession #    O14805; Q6DR95; Q7LFU2; B2R4Z1 [Other Products]
 UniProt Related Accession #    Q99497 [Other Products]
 Molecular Weight    19,891 Da
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 NCBI Official Full Name    protein DJ-1
 NCBI Official Synonym Full Names    parkinson protein 7
 NCBI Official Symbol    PARK7 [Similar Products]
 NCBI Official Synonym Symbols   
DJ1; DJ-1; HEL-S-67p
[Similar Products]
 NCBI Protein Information    protein DJ-1; Parkinson disease (autosomal recessive, early onset) 7; epididymis secretory sperm binding protein Li 67p; oncogene DJ1
 UniProt Protein Name    Protein DJ-1
 UniProt Synonym Protein Names   
Oncogene DJ1; Parkinson disease protein 7
 Protein Family    Protein deglycase
 UniProt Gene Name    PARK7 [Similar Products]
 UniProt Entry Name    PARK7_HUMAN
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 NCBI Summary for PARK7    The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PARK7    DJ-1: associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration.

Protein type: Transcription regulation; Tumor suppressor; EC 3.4.-.-; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p36.23

Cellular Component: PML body; mitochondrion; mitochondrial matrix; axon; cytoplasm; plasma membrane; mitochondrial intermembrane space; mitochondrial respiratory chain complex I; chromatin; nucleus; cytosol; lipid raft

Molecular Function: identical protein binding; oxidoreductase activity, acting on peroxide as acceptor; protein homodimerization activity; transcription coactivator activity; mercury ion binding; transcription factor binding; mRNA binding; peptidase activity; protein binding; enzyme binding; copper ion binding; peroxiredoxin activity; androgen receptor binding; cytokine binding; double-stranded DNA binding; glyoxalase III activity; superoxide dismutase copper chaperone activity; kinase binding; single-stranded DNA binding; receptor binding

Biological Process: negative regulation of protein export from nucleus; adult locomotory behavior; protein deglycosylation; membrane hyperpolarization; proteolysis; glycolate biosynthetic process; positive regulation of interleukin-8 production; negative regulation of protein amino acid phosphorylation; regulation of mitochondrial membrane potential; single fertilization; regulation of neuron apoptosis; enzyme active site formation via L-cysteine sulfinic acid; dopamine uptake; negative regulation of neuron apoptosis; negative regulation of protein binding; inflammatory response; mitochondrion organization and biogenesis; protein stabilization; activation of protein kinase B; regulation of TRAIL receptor biosynthetic process; detoxification of copper ion; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein sumoylation; positive regulation of peptidyl-serine phosphorylation; methylglyoxal catabolic process to D-lactate; positive regulation of protein kinase B signaling cascade; membrane depolarization; detoxification of mercury ion; regulation of inflammatory response; Ras protein signal transduction; negative regulation of ubiquitin-protein ligase activity; hydrogen peroxide metabolic process; negative regulation of protein kinase activity; autophagy; lactate biosynthetic process; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein ubiquitination; negative regulation of apoptosis

Disease: Parkinson Disease 7, Autosomal Recessive Early-onset
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 Research Articles on PARK7    1. High serum levels of DJ-1 are associated with endometrial cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PARK7 recombinant proteinPathways associated with PARK7 recombinant protein
 Reference Product  PubMed Publications
 PARK2 recombinant protein  >348 publications with PARK7 and PARK2
 PTEN recombinant protein  >138 publications with PARK7 and PTEN
 SNCA recombinant protein  >53 publications with PARK7 and SNCA
 SOD1 recombinant protein  >9 publications with PARK7 and SOD1
 MAP3K5 recombinant protein  >2 publications with PARK7 and MAP3K5
 AKT1 recombinant protein  >2 publications with PARK7 and AKT1
 MTA1 recombinant protein  >1 publications with PARK7 and MTA1
 PIAS2 recombinant protein  >1 publications with PARK7 and PIAS2
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Synaptic Vesicle Pathway antibodies  Synaptic Vesicle Pathway Diagram
Diseases associated with PARK7 recombinant proteinOrgans/Tissues associated with PARK7 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >377 publications with PARK7 and Nervous System Diseases
 Brain Diseases Antibodies  >372 publications with PARK7 and Brain Diseases
 Movement Disorders Antibodies  >344 publications with PARK7 and Movement Disorders
 Parkinson Disease Antibodies  >323 publications with PARK7 and Parkinson Disease
 Death Antibodies  >111 publications with PARK7 and Death
 Disease Models, Animal Antibodies  >41 publications with PARK7 and Disease Models, Animal
 Mental Disorders Antibodies  >21 publications with PARK7 and Mental Disorders
 Cardiovascular Diseases Antibodies  >19 publications with PARK7 and Cardiovascular Diseases
 Nerve Degeneration Antibodies  >17 publications with PARK7 and Nerve Degeneration
 Parkinson Disease, Secondary Antibodies  >16 publications with PARK7 and Parkinson Disease, Secondary
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >165 publications with PARK7 and Brain
 Nerve Antibodies  >65 publications with PARK7 and Nerve
 Blood Antibodies  >50 publications with PARK7 and Blood
 Lung Antibodies  >21 publications with PARK7 and Lung
 Heart Antibodies  >16 publications with PARK7 and Heart
 Muscle Antibodies  >16 publications with PARK7 and Muscle
 Prostate Antibodies  >11 publications with PARK7 and Prostate
 Liver Antibodies  >9 publications with PARK7 and Liver
 Eye Antibodies  >9 publications with PARK7 and Eye
 Kidney Antibodies  >9 publications with PARK7 and Kidney
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