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PNPLA2 recombinant protein :: Patatin-like phospholipase domain-containing protein 2  Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1400129
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $925 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,240 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,370 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,945 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Patatin-like phospholipase domain-containing protein 2  (PNPLA2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Patatin-like phospholipase domain-containing protein 2 

 Product Synonym Names    Adipose triglyceride lipase; Calcium-independent phospholipase A2; Desnutrin; IPLA2-zeta; Pigment epithelium-derived factor; TTS2.2; Transport-secretion protein 2; TTS2
 Product Gene Name   

PNPLA2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS1400129 COA    COA PDF
 Sequence Positions    1-504aa; Full Length
 Sequence    MFPREKTWNI SFAGCGFLGV YYVGVASCLR EHAPFLVANA THIYGASAGA LTATALVTGV CLGEAGAKFI EVSKEARKRF LGPLHPSFNL VKIIRSFLLK VLPADSHEHA SGRLGISLTR VSDGENVIIS HFNSKDELIQ ANVCSGFIPV YCGLIPPSLQ GVRYVDGGIS DNLPLYELKN TITVSPFSGE SDICPQDSST NIHELRVTNT SIQFNLRNLY RLSKALFPPE PLVLREMCKQ GYRDGLRFLQ RNGLLNRPNP LLALPPARPH GPEDKDQAVE SAQAEDYSQL PGEDHILEHL PARLNEALLE ACVEPTDLLT TLSNMLPVRL ATAMMVPYTL PLESALSFTI RLLEWLPDVP EDIRWMKEQT GSICQYLVMR AKRKLGRHLP SRLPEQVELR RVQSLPSVPL SCAAYREALP GWMRNNLSLG DALAKWEECQ RQLLLGLFCT NVAFPPEALR MRAPADPAPA PADPASPQHQ LAGPAPLLST PAPEARPVIG ALGL
 OMIM    609059
 3D Structure    ModBase 3D Structure for Q96AD5
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PNPLA2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PNPLA2 recombinant protein

   Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion
 Product Categories/Family for PNPLA2 recombinant protein    Cardiovascular
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 SDS-Page of PNPLA2 recombinant protein    PNPLA2 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PNPLA2. It may not necessarily be applicable to this product.
 NCBI GI #    32698724
 NCBI GeneID    57104
 NCBI Accession #    NP_065109.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020376.3 [Other Products]
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 UniProt Primary Accession #    Q96AD5 [Other Products]
 UniProt Secondary Accession #    O60643; Q5EFF5; Q6XYE5; Q96ET6; Q9NQ61; Q9NQ62 [Other Products]
 UniProt Related Accession #    Q96AD5 [Other Products]
 Molecular Weight    71.28kD
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 NCBI Official Full Name    patatin-like phospholipase domain-containing protein 2
 NCBI Official Synonym Full Names    patatin like phospholipase domain containing 2
 NCBI Official Symbol    PNPLA2 [Similar Products]
 NCBI Official Synonym Symbols   
ATGL; TTS2; PEDF-R; FP17548; TTS-2.2; iPLA2zeta; 1110001C14Rik
[Similar Products]
 NCBI Protein Information    patatin-like phospholipase domain-containing protein 2
 UniProt Protein Name    Patatin-like phospholipase domain-containing protein 2
 UniProt Synonym Protein Names   
Adipose triglyceride lipase; Calcium-independent phospholipase A2; Desnutrin; IPLA2-zeta; Pigment epithelium-derived factor; TTS2.2; Transport-secretion protein 2; TTS2
 Protein Family    Patatin-like phospholipase domain-containing protein
 UniProt Gene Name    PNPLA2 [Similar Products]
 UniProt Synonym Gene Names    ATGL; TTS2 [Similar Products]
 UniProt Entry Name    PLPL2_HUMAN
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 NCBI Summary for PNPLA2    This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]
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 UniProt Comments for PNPLA2    PNPLA2: the rate-limiting lipolytic enzyme in mammals, flies, and yeast. Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Upregulated by exercise training in human skeletal muscle. Has acylglycerol transacylase activity. May act coordinately with HSL within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Interacting with ABHD5 stimulates its triglyceride hydrolase activity. Despite a colocalization in lipid droplets, it probably does not interact with perilipin. Transcriptionally regulated by FOXO1A. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipase; EC 3.1.1.3; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: cytosol; endoplasmic reticulum membrane; integral to membrane; lipid particle; plasma membrane

Molecular Function: triacylglycerol lipase activity

Biological Process: glycerophospholipid biosynthetic process; phospholipid metabolic process; sequestering of lipid; triacylglycerol catabolic process

Disease: Neutral Lipid Storage Disease With Myopathy
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Product References and Citations for PNPLA2 recombinant protein

   "TTS-2, a novel protein implicated in vesicular transport of the cell surface receptor ICAM-3." Strahl T., Shingler W.H., Lammiman M., Gregory C.D., Leach L., Matthias P., Nielsen P.J., Shaw P.E. Submitted (JUN-2000)
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 Research Articles on PNPLA2    1. PLIN5 was significantly colocated with ATGL, mitochondria and CGI-58, indicating a close association between the key lipolytic effectors in resting skeletal muscle.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PNPLA2 recombinant proteinPathways associated with PNPLA2 recombinant protein
 Reference Product  PubMed Publications
 ABHD5 recombinant protein  >34 publications with PNPLA2 and ABHD5
 LPL recombinant protein  >6 publications with PNPLA2 and LPL
 DGAT1 recombinant protein  >6 publications with PNPLA2 and DGAT1
 PLIN5 recombinant protein  >4 publications with PNPLA2 and PLIN5
 PLIN1 recombinant protein  >4 publications with PNPLA2 and PLIN1
 LPIN1 recombinant protein  >3 publications with PNPLA2 and LPIN1
 MGLL recombinant protein  >3 publications with PNPLA2 and MGLL
 DGAT2 recombinant protein  >2 publications with PNPLA2 and DGAT2
 Products by Pathway  Pathway Diagram
 Acyl Chain Remodeling Of DAG And TAG Pathway antibodies  Acyl Chain Remodeling Of DAG And TAG Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Acylglycerol Degradation Pathway antibodies  Acylglycerol Degradation Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
Diseases associated with PNPLA2 recombinant proteinOrgans/Tissues associated with PNPLA2 recombinant protein
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >40 publications with PNPLA2 and Fatty Liver
 Insulin Resistance Antibodies  >29 publications with PNPLA2 and Insulin Resistance
 Liver Diseases Antibodies  >22 publications with PNPLA2 and Liver Diseases
 Neutral Lipid Storage Disease with Myopathy Antibodies  >21 publications with PNPLA2 and Neutral Lipid Storage Disease with Myopathy
 Heart Diseases Antibodies  >14 publications with PNPLA2 and Heart Diseases
 Inflammation Antibodies  >13 publications with PNPLA2 and Inflammation
 Non-alcoholic Fatty Liver Disease Antibodies  >11 publications with PNPLA2 and Non-alcoholic Fatty Liver Disease
 Necrosis Antibodies  >9 publications with PNPLA2 and Necrosis
 Hypertrophy Antibodies  >5 publications with PNPLA2 and Hypertrophy
 Atherosclerosis Antibodies  >5 publications with PNPLA2 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >68 publications with PNPLA2 and Adipose Tissue
 Muscle Antibodies  >45 publications with PNPLA2 and Muscle
 Connective Tissue Antibodies  >44 publications with PNPLA2 and Connective Tissue
 Liver Antibodies  >44 publications with PNPLA2 and Liver
 Blood Antibodies  >40 publications with PNPLA2 and Blood
 Heart Antibodies  >19 publications with PNPLA2 and Heart
 Eye Antibodies  >15 publications with PNPLA2 and Eye
 Skin Antibodies  >10 publications with PNPLA2 and Skin
 Brain Antibodies  >7 publications with PNPLA2 and Brain
 Kidney Antibodies  >5 publications with PNPLA2 and Kidney
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