AP_000170.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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Molecular Weight
63,255 Da
NCBI Official Full Name
III
UniProt Protein Name
Penton protein
UniProt Synonym Protein Names
Penton base protein
UniProt Synonym Gene Names
UniProt Comments for PIII
Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein. Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions. Mediates initial virus attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus. As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.
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Products associated with PIII recombinant protein
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