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Prf1 recombinant protein :: Perforin-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS950325
SDS-PAGE
Unit / Price
0.01 mg (Yeast)  /  $225 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $290 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $495 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $795 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $960 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,155 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,285 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,305 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,405 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,415 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,465 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,015 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,065 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,095 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,115 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,755 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Perforin-1 (Prf1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Perforin-1

 Product Synonym Names    P1; Cytolysin; Lymphocyte pore-forming protein
 Product Gene Name   

Prf1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS950325 COA    COA PDF
 Sequence Positions    638-767. partial protein;
 Sequence    SMVLGSGSGV FKCGIAVAPV SRWEYYDSVY TERYMGLPTP EDNLDHYRNS TVMSRAENFK QVEYLLIHGT ADDNVHFQQS AQISKALVDA GVDFQAMWYT DEDHGIASST AHQHIYSHMS HFLQQCFSLR
 3D Structure    ModBase 3D Structure for P10820
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Prf1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Prf1 recombinant protein

   Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.
 Product Categories/Family for Prf1 recombinant protein    Immunology
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 SDS-PAGE of Prf1 recombinant protein    Prf1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Prf1. It may not necessarily be applicable to this product.
 NCBI GI #    225735600
 NCBI GeneID    18646
 NCBI Accession #    NP_035203.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_011073.3 [Other Products]
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 UniProt Primary Accession #    P10820 [Other Products]
 UniProt Related Accession #    P10820 [Other Products]
 Molecular Weight    63.98kD
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 NCBI Official Full Name    perforin-1
 NCBI Official Synonym Full Names    perforin 1 (pore forming protein)
 NCBI Official Symbol    Prf1 [Similar Products]
 NCBI Official Synonym Symbols   
Pfn; Pfp; Prf-1
[Similar Products]
 NCBI Protein Information    perforin-1
 UniProt Protein Name    Perforin-1
 UniProt Synonym Protein Names   
Cytolysin; Lymphocyte pore-forming protein
 Protein Family    Perforin
 UniProt Gene Name    Prf1 [Similar Products]
 UniProt Synonym Gene Names    Pfp; P1 [Similar Products]
 UniProt Entry Name    PERF_MOUSE
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 UniProt Comments for Prf1    PRF1: Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Monomer, as sobluble protein. Homooligomer. Oligomerization is required for pore formation. Repressed by contact with target cells. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Membrane protein, multi-pass

Cellular Component: cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; endosome; extracellular region; extracellular space; integral to membrane; membrane; plasma membrane

Molecular Function: calcium ion binding; metal ion binding; wide pore channel activity

Biological Process: apoptosis; circadian rhythm; cytolysis; defense response to tumor cell; defense response to virus; formation of immunological synapse; immune response to tumor cell; protein homooligomerization; transmembrane transport
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Product References and Citations for Prf1 recombinant protein

   "The molecular basis for perforin oligomerization and transmembrane pore assembly." Baran K., Dunstone M., Chia J., Ciccone A., Browne K.A., Clarke C.J.P., Lukoyanova N., Saibil H., Whisstock J.C., Voskoboinik I., Trapani J.A. Immunity 30:684-695(2009)
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 Research Articles on Prf1    1. it is proposed that Ca(2+) binding at the weakest affinity site triggers changes in the perforin C2 domain that facilitate its interaction with lipid membranes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Prf1 recombinant proteinPathways associated with Prf1 recombinant protein
 Reference Product  PubMed Publications
 Gzmb recombinant protein  >43 publications with Prf1 and Gzmb
 Tnf recombinant protein  >10 publications with Prf1 and Tnf
 Gzma recombinant protein  >4 publications with Prf1 and Gzma
 Fasl recombinant protein  >3 publications with Prf1 and Fasl
 Klrd1 recombinant protein  >2 publications with Prf1 and Klrd1
 Ccr7 recombinant protein  >2 publications with Prf1 and Ccr7
 Ncam1 recombinant protein  >1 publications with Prf1 and Ncam1
 Products by Pathway  Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Type I Diabetes Mellitus Pathway antibodies  Type I Diabetes Mellitus Pathway Diagram
Diseases associated with Prf1 recombinant proteinOrgans/Tissues associated with Prf1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >24 publications with Prf1 and Inflammation
 Death Antibodies  >16 publications with Prf1 and Death
 Lymphoma, Non-Hodgkin Antibodies  >12 publications with Prf1 and Lymphoma, Non-Hodgkin
 Liver Diseases Antibodies  >9 publications with Prf1 and Liver Diseases
 Necrosis Antibodies  >8 publications with Prf1 and Necrosis
 Lung Diseases Antibodies  >5 publications with Prf1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >3 publications with Prf1 and Neoplasms, Experimental
 Hemophagocytic lymphohistiocytosis, familial, 2 Antibodies  >3 publications with Prf1 and Hemophagocytic lymphohistiocytosis, familial, 2
 Carcinoma, Hepatocellular Antibodies  >2 publications with Prf1 and Carcinoma, Hepatocellular
 Edema Antibodies  >2 publications with Prf1 and Edema
 Organ/Tissue Name  Pubmed Publications
 Spleen Antibodies  >4 publications with Prf1 and Spleen
 Uterus Antibodies  >1 publications with Prf1 and Uterus
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