NP_036226.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,897 Da
NCBI Official Full Name
peroxiredoxin-5, mitochondrial isoform a
NCBI Official Synonym Full Names
peroxiredoxin 5
NCBI Official Synonym Symbols
PLP; ACR1; B166; PRXV; PMP20; PRDX6; prx-V; SBBI10; AOEB166; HEL-S-55 [Similar Products]
NCBI Protein Information
peroxiredoxin-5, mitochondrial; Alu co-repressor 1; TPx type VI; antioxidant enzyme B166; epididymis secretory protein Li 55; liver tissue 2D-page spot 71B; peroxiredoxin V; peroxisomal antioxidant enzyme; thioredoxin peroxidase PMP20; thioredoxin reductase
UniProt Protein Name
Peroxiredoxin-5, mitochondrial
UniProt Synonym Protein Names
Alu corepressor 1; Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 71B; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; TPx type VI; Thioredoxin peroxidase PMP20; Thioredoxin reductase
UniProt Synonym Gene Names
UniProt Entry Name
PRDX5_HUMAN
NCBI Summary for PRDX5
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. This protein interacts with peroxisome receptor 1. The crystal structure of this protein in its reduced form has been resolved to 1.5 angstrom resolution. This gene uses alternate in-frame translation initiation sites to generate mitochondrial or peroxisomal/cytoplasmic forms. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PRDX5
PRDX5: Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling. Belongs to the peroxiredoxin 2 family. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Oxidoreductase; EC 1.11.1.15
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: extracellular space; peroxisomal matrix; intracellular membrane-bound organelle; mitochondrion; perinuclear region of cytoplasm; mitochondrial matrix; cytoplasm; peroxisome; cytoplasmic vesicle; cytosol; nucleus
Molecular Function: antioxidant activity; protein dimerization activity; peroxidase activity; peroxiredoxin activity; caspase inhibitor activity; receptor binding
Biological Process: response to reactive oxygen species; hydrogen peroxide catabolic process; negative regulation of oxidoreductase activity; negative regulation of transcription from RNA polymerase III promoter; positive regulation of collagen biosynthetic process; response to oxidative stress; negative regulation of caspase activity; inflammatory response; negative regulation of apoptosis
Research Articles on PRDX5
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Products associated with PRDX5 active protein
Pathways associated with PRDX5 active protein
Diseases associated with PRDX5 active protein
Organs/Tissues associated with PRDX5 active protein
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