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PRDX6 recombinant protein :: Peroxiredoxin-6 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143893 PRDX6 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Peroxiredoxin-6 (PRDX6), Recombinant Protein

 Also Known As   

Recombinant Human Peroxiredoxin-6

 Product Synonym Names    PRDX6 Human; Peroxiredoxin-6 Human Recombinant; Peroxiredoxin-6; Antioxidant protein 2; 1-Cys peroxiredoxin; Acidic calcium-independent phospholipase A2; Non-selenium glutathione peroxidase; 24 kDa protein; Liver 2D page spot 40; Red blood cells page spot 12; 1-Cys PRX; aiPLA2; NSGPx; PRDX6; AOP2; KIAA0106; PRX; p29; 1-Cys; MGC46173
 Product Gene Name   

PRDX6 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS143893 MSDS    MSDS PDF
 Sequence    MGSSHHH HHH SSGLVPRGSH MPGGLLLGDV APNFEANTTV GRIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE FAKRNVKLIA LSIDSVEDHL AWSKDINAYN CEEPTEKLPF PIIDDRNREL AILLGMLDPA EKDEKGMPVT ARVVFVFGPD KKLKLSILYP ATTGRNFDEI LRVVISLQLT AEKRVATPVD WKDGDSVMVL PTIPEEEAKK LFPKGVFTKE LPSGKKYLRY TPQP
 OMIM    602316
 3D Structure    ModBase 3D Structure for P30041
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The Peroxiredoxin-6 solution contains 20mM Tris-HCl buffer (pH8.0) and 20% Glycerol.
Sterile Filtered colorless solution.
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 Biological Activity    The specific activity was found to be approximately 95-120 pmole/min/ ug. The enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX6 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25 degree C for 1 minute.
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 Other Notes    Small volumes of PRDX6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PRDX6 recombinant protein

   Description: Peroxiredoxin- 6 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 244 amino acids (1-224 a.a.) and having a molecular mass of 27.1kDa.The Peroxiredoxin-6 is purified by proprietary chromatographic techniques.

Introduction: Peroxiredoxin 6 (PRDX6) belongs to the thiol-specific antioxidant protein family. PRDX6 is a bifunctional enzyme with 2 distinct active sites. PRDX6 is involved in redox regulation of the cell and can reduce Hydrogen peroxide and short chain organic, fatty acid, and phospholipid hydroperoxides. PRDX6 may have a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. Furthermore, PRDX6 eases the oxidative stress and TGF-beta-induced abnormalities of human trabecular meshwork cells. In addition, PRDX6 is necessary for blood vessel integrity in injured skin. At acidic pH, PRDX6 binds to reduced phospholipids, however at cytosolic pH PRDX6 binds only to phospholipids that are oxidized which is compatible with the role for PRDX6 in the repair of peroxidized cell membranes. Hydrogen peroxide-mediated hyperoxidation of PRDX6 induces cell cycle arrest at the G2/M transition via up-regulation of iPLA2 activity. Overexpression of PRDX6 is linked to oligodendroglioma.
 Product Categories/Family for PRDX6 recombinant protein    ENZYMES; Enzymes; Peroxiredoxin
NCBI/Uniprot data below describe general gene information for PRDX6. It may not necessarily be applicable to this product.
 NCBI GI #    4758638
 NCBI GeneID    9588
 NCBI Accession #    NP_004896.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004905.2 [Other Products]
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 UniProt Primary Accession #    P30041 [Other Products]
 UniProt Secondary Accession #    P32077; Q5TAH4; Q5ZEZ8; A8JZY7 [Other Products]
 UniProt Related Accession #    P30041 [Other Products]
 Molecular Weight    25,035 Da
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 NCBI Official Full Name    peroxiredoxin-6
 NCBI Official Synonym Full Names    peroxiredoxin 6
 NCBI Official Symbol    PRDX6 [Similar Products]
 NCBI Official Synonym Symbols   
PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; HEL-S-128m
[Similar Products]
 NCBI Protein Information    peroxiredoxin-6; 1-Cys PRX; 1-Cys peroxiredoxin; 24 kDa protein; acidic calcium-independent phospholipase A2; antioxidant protein 2; epididymis secretory sperm binding protein Li 128m; liver 2D page spot 40; non-selenium glutathione peroxidase; red blood cells page spot 12
 UniProt Protein Name    Peroxiredoxin-6
 UniProt Synonym Protein Names   
1-Cys peroxiredoxin; 1-Cys PRX; 24 kDa protein; Acidic calcium-independent phospholipase A2 (EC:3.1.1.-); aiPLA2; Antioxidant protein 2; Liver 2D page spot 40; Non-selenium glutathione peroxidase (EC:1.11.1.9); NSGPx; Red blood cells page spot 12
 Protein Family    Peroxiredoxin
 UniProt Gene Name    PRDX6 [Similar Products]
 UniProt Synonym Gene Names    AOP2; KIAA0106; 1-Cys PRX; aiPLA2; NSGPx [Similar Products]
 UniProt Entry Name    PRDX6_HUMAN
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 NCBI Summary for PRDX6    The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRDX6    PRDX6: Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. Belongs to the AhpC/TSA family. Rehydrin subfamily.

Protein type: EC 1.11.1.9; Oxidoreductase; Energy Metabolism - methane; Amino Acid Metabolism - phenylalanine; Phospholipase; EC 1.11.1.15

Chromosomal Location of Human Ortholog: 1q25.1

Cellular Component: extracellular space; membrane; lysosome; cytoplasmic membrane-bound vesicle; cytoplasm; cytosol

Molecular Function: antioxidant activity; phospholipase A2 activity; protein binding; peroxiredoxin activity; glutathione peroxidase activity

Biological Process: response to reactive oxygen species; hydrogen peroxide catabolic process; phospholipid catabolic process; response to oxidative stress
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 Research Articles on PRDX6    1. our findings indicate that PRDX6 promotes lung tumor growth via increased glutathione peroxidase and iPLA2 activities.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRDX6 recombinant proteinPathways associated with PRDX6 recombinant protein
 Reference Product  PubMed Publications
 CAT recombinant protein  >6 publications with PRDX6 and CAT
 TXN recombinant protein  >2 publications with PRDX6 and TXN
 TAT recombinant protein  >2 publications with PRDX6 and TAT
 PSIP1 recombinant protein  >1 publications with PRDX6 and PSIP1
 PAH recombinant protein  >1 publications with PRDX6 and PAH
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram
Diseases associated with PRDX6 recombinant proteinOrgans/Tissues associated with PRDX6 recombinant protein
 Disease Name  Pubmed Publications
 Death Antibodies  >23 publications with PRDX6 and Death
 Lung Diseases Antibodies  >17 publications with PRDX6 and Lung Diseases
 Nervous System Diseases Antibodies  >17 publications with PRDX6 and Nervous System Diseases
 Disease Models, Animal Antibodies  >17 publications with PRDX6 and Disease Models, Animal
 Inflammation Antibodies  >16 publications with PRDX6 and Inflammation
 Necrosis Antibodies  >10 publications with PRDX6 and Necrosis
 Cardiovascular Diseases Antibodies  >9 publications with PRDX6 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >8 publications with PRDX6 and Atherosclerosis
 Liver Diseases Antibodies  >7 publications with PRDX6 and Liver Diseases
 Lung Neoplasms Antibodies  >6 publications with PRDX6 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >48 publications with PRDX6 and Lung
 Blood Antibodies  >29 publications with PRDX6 and Blood
 Liver Antibodies  >28 publications with PRDX6 and Liver
 Brain Antibodies  >27 publications with PRDX6 and Brain
 Eye Antibodies  >16 publications with PRDX6 and Eye
 Vascular Antibodies  >16 publications with PRDX6 and Vascular
 Kidney Antibodies  >11 publications with PRDX6 and Kidney
 Muscle Antibodies  >10 publications with PRDX6 and Muscle
 Nerve Antibodies  >8 publications with PRDX6 and Nerve
 Skin Antibodies  >7 publications with PRDX6 and Skin
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