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PRDX6 recombinant protein :: Peroxiredoxin 6 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS203357
SDS-Page
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Peroxiredoxin 6 (PRDX6), Recombinant Protein

 Also Known As   

Peroxiredoxin 6, 1-224aa, Human, His tag, E Coli (Bioactivity Validated)

 Product Synonym Names    1-Cys; aiPLA2; AOP2; NSGPx; p29; PRX; Peroxiredoxin6; PRDX6; PRDX 6; PRDX-6; AA690119; Prdx6 rs3; 1 Cys; 1 Cys peroxiredoxin; 1 Cys PRX; 1 cysPrx; 24 kDa protein; 9430088D19Rik; Acidic calcium independent phospholipase A2; Antioxidant protein 2; Aop2 rs3; Brp 12; mKIAA0106; Ciliary body glutathione peroxidase; CP 3; EC 1.11.1.15; EC 1.11.1.7; EC 3.1.1; GPx; KIAA0106; Liver 2D page spot 40; Ltw4; Lvtw 4; MGC46173; Non selenium glutathione peroxidase; NSGPx; ORF06; OTTHuMP00000032693; Peroxiredoxin6; PHGPx; Phospholipase A2 lysosomal; PLA2; Prdx5; PRX; Red blood cells page spot 12; Thiol specific antioxidant protein
 Product Gene Name   

PRDX6 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MPGGLLLGDV APNFEANTTV GRIRFHDFLG DSWGILFSHP RDFTPVCTTE LGRAAKLAPE FAKRNVKLIA LSIDSVEDHL AWSKDINAYN CEEPTEKLPF PIIDDRNREL AILLGMLDPA EKDEKGMPVT ARVVFVFGPD KKLKLSILYP ATTGRNFDEI LRVVISLQLT AEKRVATPVD WKDGDSVMVL PTIPEEEAKK LFPKGVFTKE LPSGKKYLRY TPQP
 OMIM    D14662 mRNA
 3D Structure    ModBase 3D Structure for P30041
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 Host    E Coli
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 Purity/Purification    > 95% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 20% glycerol
 Concentration    1 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
 Biological Activity    Specific activity is >2,000 pmol/min/ug. Enzymatic activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25C for 1minute.
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of PRDX6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PRDX6 recombinant protein

   Peroxiredoxin 6, also known as PRDX6, is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell and can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. Recombinant human peroxiredoxin 6 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography.
 Product Categories/Family for PRDX6 recombinant protein    Redox Proteins
 Applications Tested/Suitable for PRDX6 recombinant protein   

SDS-PAGE

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 SDS-Page of PRDX6 recombinant protein    PRDX6 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for PRDX6. It may not necessarily be applicable to this product.
 NCBI GI #    4758638
 NCBI GeneID    9588
 NCBI Accession #    NP_004896 [Other Products]
 NCBI GenBank Nucleotide #    NM_004905.2 [Other Products]
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 UniProt Primary Accession #    P30041 [Other Products]
 UniProt Secondary Accession #    P32077; Q5TAH4; Q5ZEZ8; A8JZY7 [Other Products]
 UniProt Related Accession #    P30041 [Other Products]
 Molecular Weight    27.1 kDa (244aa), confirmed by MALDI-TOF. [Similar Products]
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 NCBI Official Full Name    peroxiredoxin-6
 NCBI Official Synonym Full Names    peroxiredoxin 6
 NCBI Official Symbol    PRDX6 [Similar Products]
 NCBI Official Synonym Symbols   
PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; HEL-S-128m
[Similar Products]
 NCBI Protein Information    peroxiredoxin-6
 UniProt Protein Name    Peroxiredoxin-6
 UniProt Synonym Protein Names   
1-Cys peroxiredoxin; 1-Cys PRX; 24 kDa protein; Acidic calcium-independent phospholipase A2 (EC:3.1.1.4
 Protein Family    Peroxiredoxin
 UniProt Gene Name    PRDX6 [Similar Products]
 UniProt Synonym Gene Names    AOP2; KIAA0106; aiPLA2; NSGPx [Similar Products]
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 NCBI Summary for PRDX6    The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRDX6    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis.
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Product References and Citations for PRDX6 recombinant protein

   Davison EJ., et al. (2009). Proteomics. 9 (18):4284-97.; Wu J., et al. (2009). Chem Res Toxicol. 22 (4):668-75.;
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 Research Articles on PRDX6    1. the transition-state substrate analogue inhibitor of Prdx6 phospholipase A2 activity (MJ-33) was shown to suppress Nox1 activity, suggesting Nox1 activity is regulated by the phospholipase activity of Prdx6. Finally, wild type Prdx6, but not lipase or peroxidase mutant forms, supports Nox1-mediated cell migration in the HCT-116 colon epithelial cell model of wound closure
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRDX6 recombinant proteinPathways associated with PRDX6 recombinant protein
 Reference Product  PubMed Publications
 PRDX2 recombinant protein  >19 publications with PRDX6 and PRDX2
 PRDX5 recombinant protein  >14 publications with PRDX6 and PRDX5
 CAT recombinant protein  >9 publications with PRDX6 and CAT
 GSTP1 recombinant protein  >8 publications with PRDX6 and GSTP1
 TXN recombinant protein  >3 publications with PRDX6 and TXN
 TXN2 recombinant protein  >2 publications with PRDX6 and TXN2
 PDIA3 recombinant protein  >2 publications with PRDX6 and PDIA3
 Products by Pathway  Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Detoxification Of Reactive Oxygen Species Pathway antibodies  Detoxification Of Reactive Oxygen Species Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 NRF2 Pathway antibodies  NRF2 Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
Diseases associated with PRDX6 recombinant proteinOrgans/Tissues associated with PRDX6 recombinant protein
 Disease Name  Pubmed Publications
 Death Antibodies  >42 publications with PRDX6 and Death
 Nervous System Diseases Antibodies  >30 publications with PRDX6 and Nervous System Diseases
 Disease Models, Animal Antibodies  >28 publications with PRDX6 and Disease Models, Animal
 Inflammation Antibodies  >25 publications with PRDX6 and Inflammation
 Lung Injury Antibodies  >17 publications with PRDX6 and Lung Injury
 Lung Neoplasms Antibodies  >12 publications with PRDX6 and Lung Neoplasms
 Necrosis Antibodies  >11 publications with PRDX6 and Necrosis
 Liver Diseases Antibodies  >10 publications with PRDX6 and Liver Diseases
 Atherosclerosis Antibodies  >8 publications with PRDX6 and Atherosclerosis
 Liver Neoplasms Antibodies  >8 publications with PRDX6 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >65 publications with PRDX6 and Lung
 Brain Antibodies  >45 publications with PRDX6 and Brain
 Blood Antibodies  >44 publications with PRDX6 and Blood
 Liver Antibodies  >37 publications with PRDX6 and Liver
 Eye Antibodies  >21 publications with PRDX6 and Eye
 Vascular Antibodies  >20 publications with PRDX6 and Vascular
 Muscle Antibodies  >16 publications with PRDX6 and Muscle
 Nerve Antibodies  >15 publications with PRDX6 and Nerve
 Kidney Antibodies  >15 publications with PRDX6 and Kidney
 Skin Antibodies  >8 publications with PRDX6 and Skin
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