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PPARgC1a recombinant protein :: Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2009392 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $150 +1 FREE 8GB USB
0.05 mg  /  $285 +1 FREE 8GB USB
0.1 mg  /  $445 +1 FREE 8GB USB
0.2 mg  /  $550 +1 FREE 8GB USB
0.5 mg  /  $1,060 +1 FREE 8GB USB
1 mg  /  $1,580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (PPARgC1a)

 Product Gene Name   

PPARgC1a recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_005113.3 (63182479..63286252). Location: 14q11
 3D Structure    ModBase 3D Structure for Q9QYK2
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 Host    E.coli
 Species Reactivity    Rat
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 Purity/Purification    >92%
 Form/Format    PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.
 Concentration    200ug/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Ser588~Ser773
 Tags    N-terminal His-Tag
 Tissue Specificity    Heart
 Subcellular Location    Nucleus
 Traits    Freeze-dried powder
    
 Predicted isoelectric point    8.6
 Predicted Molecular Mass    23.8kDa
 Accurate Molecular Mass    22kDa as determined by SDS-PAGE reducing conditions
 Usage    Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex
    
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of PPARgC1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for PPARgC1a recombinant protein   

SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.

(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of PPARgC1a recombinant protein    PPARgC1a recombinant protein Sequence image
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 SDS-PAGE of PPARgC1a recombinant protein    PPARgC1a recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for PPARgC1a. It may not necessarily be applicable to this product.
 NCBI GI #    13786188
 NCBI GeneID    83516
 NCBI Accession #    NP_112637.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031347.1 [Other Products]
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 UniProt Primary Accession #    Q9QYK2 [Other Products]
 UniProt Related Accession #    Q9QYK2 [Other Products]
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 NCBI Official Full Name    peroxisome proliferator-activated receptor gamma coactivator 1-alpha
 NCBI Official Synonym Full Names    peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
 NCBI Official Symbol    Ppargc1a [Similar Products]
 NCBI Official Synonym Symbols   
Ppargc1
[Similar Products]
 NCBI Protein Information    peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1alpha; PGC-1-alpha; PPARGC-1-alpha; PPAR-gamma coactivator 1-alpha; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
 UniProt Protein Name    Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
 Protein Family    Peroxisome proliferator-activated receptor gamma coactivator
 UniProt Gene Name    Ppargc1a [Similar Products]
 UniProt Synonym Gene Names    Pgc1; Pgc1a; Ppargc1; PGC-1-alpha; PPAR-gamma coactivator 1-alpha [Similar Products]
 UniProt Entry Name    PRGC1_RAT
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 NCBI Summary for PPARgC1a    nuclear receptor coactivator; may mediate glucose homeostasis, and lipid homeostasis [RGD, Feb 2006]
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 UniProt Comments for PPARgC1a    PGC-1 alpha: a transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor genes. Interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Regulates many genes involved in energy metabolism. Provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. May be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Its transcription is repressed by ZNF746 which binds to 'insulin response sequences' in its promoter. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
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 Research Articles on PPARgC1a    1. PGC-1alpha is a potent target for aluminium neurotoxicity, which makes it an almost ideal target to control or limit the damage that has been associated with the defective mitochondrial function seen in neurodegenerative diseases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PPARgC1a recombinant proteinPathways associated with PPARgC1a recombinant protein
 Reference Product  PubMed Publications
 Pparg recombinant protein  >248 publications with PPARgC1a and Pparg
 Foxo1 recombinant protein  >48 publications with PPARgC1a and Foxo1
 Tnf recombinant protein  >23 publications with PPARgC1a and Tnf
 Ppara recombinant protein  >19 publications with PPARgC1a and Ppara
 Creb1 recombinant protein  >12 publications with PPARgC1a and Creb1
 Crebbp recombinant protein  >8 publications with PPARgC1a and Crebbp
 Ep300 recombinant protein  >2 publications with PPARgC1a and Ep300
 Rxra recombinant protein  >2 publications with PPARgC1a and Rxra
 Products by Pathway  Pathway Diagram
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 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway antibodies  BMAL1:CLOCK/NPAS2 Activates Circadian Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Circadian Repression Of Expression By REV-ERBA Pathway antibodies  Circadian Repression Of Expression By REV-ERBA Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
Diseases associated with PPARgC1a recombinant proteinOrgans/Tissues associated with PPARgC1a recombinant protein
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >199 publications with PPARgC1a and Insulin Resistance
 Nervous System Diseases Antibodies  >169 publications with PPARgC1a and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >142 publications with PPARgC1a and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >121 publications with PPARgC1a and Disease Models, Animal
 Fatty Liver Antibodies  >112 publications with PPARgC1a and Fatty Liver
 Diabetes Mellitus, Type 2 Antibodies  >101 publications with PPARgC1a and Diabetes Mellitus, Type 2
 Heart Diseases Antibodies  >89 publications with PPARgC1a and Heart Diseases
 Inflammation Antibodies  >88 publications with PPARgC1a and Inflammation
 Liver Diseases Antibodies  >77 publications with PPARgC1a and Liver Diseases
 Neoplasms Antibodies  >69 publications with PPARgC1a and Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >322 publications with PPARgC1a and Liver
 Heart Antibodies  >185 publications with PPARgC1a and Heart
 Uncharacterized Tissue Antibodies  >2 publications with PPARgC1a and Uncharacterized Tissue
 Testis Antibodies  >2 publications with PPARgC1a and Testis
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