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PPARG recombinant protein :: Peroxisome Proliferator Activated Receptor Gamma Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142774 PPARG recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,665 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Peroxisome Proliferator Activated Receptor Gamma (PPARG), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Peroxisome Proliferator Activated Receptor Gamma

 Product Synonym Names    PPARG Human; Peroxisome Proliferator Activated Receptor Gamma Human Recombinant; Peroxisome proliferator-activated receptor gamma; PPAR-gamma; PPARG; NR1C3; PPARG1; PPARG2
 Product Gene Name   

PPARG recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137800
 3D Structure    ModBase 3D Structure for P37231
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The protein solution contains PBS, 50% glycerol and 0.01% azide.
Sterile Filtered clear solution.
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 Biological Activity    Specific activity is 3-4 units/ml obtained by measuring the increase of NADPH in absorbance at 340 nm resulting from the reduction of NADP. In the coupled mode, one unit will produce 1.0 umole of NADPH per minute as glucose is phosphorylated by ATP at pH 7.4 at 300C.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time.Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of PPARG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PPARG recombinant protein

   Description: Peroxisome Proliferator Activated Receptor Gamma Human Recombinant is expressed in E Coli having a molecular weight of 59.2 kDa and fused to an amino terminal hexahistidine tag.

Introduction: The peroxisome proliferator activated receptors (PPARs) are ligandactivated transcription factors within the nuclear receptor superfamily, which play important roles in adipogenesis, glucose homeostasis andinflammation. Three different isotypes can be distinguished; alpha, beta and gamma. PPARg, is mainly expressed in adipose tissue and to lesser extent in colon, the immune system and the retina. Whereas PPARg operates in the catabolism of fatty acids in the liver, PPARg influences the storage of fatty acids in the adipose tissue and plays a role in adipocyte differentiation. PPARg binds to DNA as a heterodimer with retinoid X receptor (RXR), activating expression of target genes after binding ligand.
 Product Categories/Family for PPARG recombinant protein    PROTEIN KINASES; Enzymes; Peroxisome Proliferator Activated Receptor
NCBI/Uniprot data below describe general gene information for PPARG. It may not necessarily be applicable to this product.
 NCBI GI #    116284368
 NCBI GeneID    5468
 NCBI Accession #    NP_005028.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_005037.5 [Other Products]
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 UniProt Primary Accession #    P37231 [Other Products]
 UniProt Secondary Accession #    O00684; O00710; O14515; Q0QJH8; Q15178; Q15179; Q15180; Q15832; Q86U60; A8K3G6; B5BUA1 [Other Products]
 UniProt Related Accession #    P37231 [Other Products]
 Molecular Weight    21,580 Da
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 NCBI Official Full Name    peroxisome proliferator-activated receptor gamma isoform 1
 NCBI Official Synonym Full Names    peroxisome proliferator-activated receptor gamma
 NCBI Official Symbol    PPARG [Similar Products]
 NCBI Official Synonym Symbols   
GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma
[Similar Products]
 NCBI Protein Information    peroxisome proliferator-activated receptor gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated nuclear receptor gamma variant 1
 UniProt Protein Name    Peroxisome proliferator-activated receptor gamma
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 1 group C member 3
 Protein Family    Peroxisome proliferator-activated receptor
 UniProt Gene Name    PPARG [Similar Products]
 UniProt Synonym Gene Names    NR1C3; PPAR-gamma [Similar Products]
 UniProt Entry Name    PPARG_HUMAN
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 NCBI Summary for PPARG    This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PPARG    PPAR-gamma: a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytosol; nucleus

Molecular Function: ligand-dependent nuclear receptor activity; transcription activator binding; zinc ion binding; drug binding; alpha-actinin binding; protein phosphatase binding; retinoid X receptor binding; arachidonic acid binding; protein binding; enzyme binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; prostaglandin receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; estrogen receptor binding; chromatin binding; transcription factor activity

Biological Process: negative regulation of collagen biosynthetic process; heart development; positive regulation of transcription, DNA-dependent; cell maturation; rhythmic process; lipid homeostasis; response to lipid; glucose homeostasis; response to caffeine; response to vitamin A; positive regulation of oligodendrocyte differentiation; placenta development; long-chain fatty acid transport; organ regeneration; cell fate commitment; monocyte differentiation; negative regulation of acute inflammatory response; regulation of circadian rhythm; response to starvation; negative regulation of telomerase activity; cellular response to insulin stimulus; lipoprotein transport; response to estrogen stimulus; response to mechanical stimulus; brown fat cell differentiation; positive regulation of fat cell differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; fatty acid oxidation; negative regulation of transcription, DNA-dependent; positive regulation of phagocytosis, engulfment; negative regulation of smooth muscle cell proliferation; low-density lipoprotein receptor biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; signal transduction; epithelial cell differentiation; regulation of blood pressure; response to nutrient; caspase activation; transcription initiation from RNA polymerase II promoter; response to retinoic acid; G-protein coupled receptor protein signaling pathway; response to low density lipoprotein stimulus; white fat cell differentiation; positive regulation of fatty acid oxidation; innate immune response; gene expression; negative regulation of cell growth; lipid metabolic process; response to cold

Disease: Obesity; Carotid Intimal Medial Thickness 1; Lipodystrophy, Familial Partial, Type 3; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on PPARG    1. PPAR-gamma inhibition during osteogenic induction leads to a significant up-regulation of a number of genes related to both osteogenesis and adipogenesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PPARG recombinant proteinDiseases associated with PPARG recombinant protein
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Metabolic Diseases Antibodies  >2733 publications with PPARG and Metabolic Diseases
 Inflammation Antibodies  >1908 publications with PPARG and Inflammation
 Obesity Antibodies  >1886 publications with PPARG and Obesity
 Insulin Resistance Antibodies  >1736 publications with PPARG and Insulin Resistance
 Diabetes Mellitus Antibodies  >1721 publications with PPARG and Diabetes Mellitus
 Diabetes Mellitus, Type 2 Antibodies  >1160 publications with PPARG and Diabetes Mellitus, Type 2
 Necrosis Antibodies  >972 publications with PPARG and Necrosis
 Fatty Liver Antibodies  >788 publications with PPARG and Fatty Liver
 Atherosclerosis Antibodies  >739 publications with PPARG and Atherosclerosis
 Liver Diseases Antibodies  >691 publications with PPARG and Liver Diseases
Organs/Tissues associated with PPARG recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >1847 publications with PPARG and Adipose Tissue
 Liver Antibodies  >1844 publications with PPARG and Liver
 Connective Tissue Antibodies  >1345 publications with PPARG and Connective Tissue
 Vascular Antibodies  >1237 publications with PPARG and Vascular
 Heart Antibodies  >763 publications with PPARG and Heart
 Bone Antibodies  >672 publications with PPARG and Bone
 Brain Antibodies  >620 publications with PPARG and Brain
 Kidney Antibodies  >550 publications with PPARG and Kidney
 Lung Antibodies  >473 publications with PPARG and Lung
 Intestine Antibodies  >262 publications with PPARG and Intestine
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