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PNMT recombinant protein :: Phenylethanolamine-N-Methyltransferase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143536 PNMT recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phenylethanolamine-N-Methyltransferase (PNMT), Recombinant Protein

 Also Known As   

Recombinant Human Phenylethanolamine-N-Methyltransferase

 Product Synonym Names    PNMT Human; Phenylethanolamine-N-Methyltransferase Human Recombinant; PENT; PNMTase; Noradrenaline-N-methyltransferase; Phenylethanolamine N-methyltransferase; PNMT; MGC34570
 Product Gene Name   

PNMT recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MSGADRSPNA GAAPDSAPGQ AAVASAYQRF EPRAYLRNNY APPRGDLCNP NGVGPWKLRC LAQTFATGEV SGRTLIDIGS GPTVYQLLSA CSHFEDITMT DFLEVNRQEL GRWLQEEPGA FNWSMYSQHA CLIEGKGECW QDKERQLRAR VKRVLPIDVH QPQPLGAGSP APLPADALVS AFCLEAVSPD LASFQRALDH ITTLLRPGGH LLLIGALEES WYLAGEARLT VVPVSEEEVR EALVRSGYKV RDLRTYIMPA HLQTGVDDVK GVFFAWAQKV GL
 OMIM    171190
 3D Structure    ModBase 3D Structure for P11086
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The PNMT protein solution contains 20mM Tris-HCl, pH-8 & 10% Glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of PNMT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PNMT recombinant protein

   Description: Recombinant Human PNMT produced in E Coli is a single, non-glycosylated polypeptide chain containing 282 amino acids (1-282 a.a.) and having a molecular mass of 30.8 kDa.PNMT is purified by conventional chromatographic techniques.

Introduction: PNMT is an enzyme located in the adrenal medulla and it catalyzes the final step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). PNMT has beta-carboline 2N-methyltransferase activity. PNMT takes part in regulating epinephrine production. Glucocorticoid receptors form multimers of PNMT independent of the DNA binding domain. PNMT expression is regulated late in mouse gestation by AP2-alpha and glucocorticoids.
 Product Categories/Family for PNMT recombinant protein    ENZYMES; Enzymes; Transferase
NCBI/Uniprot data below describe general gene information for PNMT. It may not necessarily be applicable to this product.
 NCBI GI #    4505921
 NCBI GeneID    5409
 NCBI Accession #    NP_002677.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002686.4 [Other Products]
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 UniProt Primary Accession #    P11086 [Other Products]
 UniProt Related Accession #    P11086 [Other Products]
 Molecular Weight    30,855 Da
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 NCBI Official Full Name    phenylethanolamine N-methyltransferase
 NCBI Official Synonym Full Names    phenylethanolamine N-methyltransferase
 NCBI Official Symbol    PNMT [Similar Products]
 NCBI Official Synonym Symbols   
PENT; PNMTase
[Similar Products]
 NCBI Protein Information    phenylethanolamine N-methyltransferase; noradrenaline N-methyltransferase; phenylethanolamine N-methylase
 UniProt Protein Name    Phenylethanolamine N-methyltransferase
 UniProt Synonym Protein Names   
Noradrenaline N-methyltransferase
 Protein Family    Phenylethanolamine N-methyltransferase
 UniProt Gene Name    PNMT [Similar Products]
 UniProt Synonym Gene Names    PENT; PNMTase [Similar Products]
 UniProt Entry Name    PNMT_HUMAN
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 NCBI Summary for PNMT    The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
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 UniProt Comments for PNMT    PNMT: Converts noradrenaline to adrenaline. Belongs to the NNMT/PNMT/TEMT family.

Protein type: Amino Acid Metabolism - tyrosine; Methyltransferase; EC 2.1.1.28

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytosol

Molecular Function: phenylethanolamine N-methyltransferase activity

Biological Process: methylation; catecholamine biosynthetic process; epinephrine biosynthetic process

Disease: Hypertension, Essential
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 Research Articles on PNMT    1. initial velocity studies on human PNMT in the absence and presence of product and dead end inhibitors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PNMT recombinant proteinPathways associated with PNMT recombinant protein
 Reference Product  PubMed Publications
 DBH recombinant protein  >188 publications with PNMT and DBH
 COMT recombinant protein  >29 publications with PNMT and COMT
 SP1 recombinant protein  >20 publications with PNMT and SP1
 TCAP recombinant protein  >8 publications with PNMT and TCAP
 C17orf37 recombinant protein  >4 publications with PNMT and C17orf37
 MAOA recombinant protein  >4 publications with PNMT and MAOA
 MAOB recombinant protein  >1 publications with PNMT and MAOB
 Products by Pathway  Pathway Diagram
 Amine-derived Hormones Pathway antibodies  Amine-derived Hormones Pathway Diagram
 Biogenic Amine Synthesis Pathway antibodies  Biogenic Amine Synthesis Pathway Diagram
 Catecholamine Biosynthesis Pathway antibodies  Catecholamine Biosynthesis Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
Diseases associated with PNMT recombinant proteinOrgans/Tissues associated with PNMT recombinant protein
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >68 publications with PNMT and Hypertension
 Nervous System Diseases Antibodies  >43 publications with PNMT and Nervous System Diseases
 Disease Models, Animal Antibodies  >27 publications with PNMT and Disease Models, Animal
 Hypotension Antibodies  >14 publications with PNMT and Hypotension
 Pain Antibodies  >12 publications with PNMT and Pain
 Heart Diseases Antibodies  >11 publications with PNMT and Heart Diseases
 Bradycardia Antibodies  >9 publications with PNMT and Bradycardia
 Movement Disorders Antibodies  >7 publications with PNMT and Movement Disorders
 Kidney Diseases Antibodies  >7 publications with PNMT and Kidney Diseases
 Heart Failure Antibodies  >7 publications with PNMT and Heart Failure
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >450 publications with PNMT and Brain
 Adrenal Gland Antibodies  >337 publications with PNMT and Adrenal Gland
 Eye Antibodies  >26 publications with PNMT and Eye
 Thyroid Antibodies  >10 publications with PNMT and Thyroid
 Placenta Antibodies  >2 publications with PNMT and Placenta
 Uterus Antibodies  >2 publications with PNMT and Uterus
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