NP_001009967.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
75,594 Da
NCBI Official Full Name
phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform c
NCBI Official Synonym Full Names
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
NCBI Protein Information
phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
UniProt Protein Name
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
UniProt Synonym Protein Names
Phosphatidylinositol 4-phosphate 5-kinase type I gamma; PIP5KIgamma
UniProt Synonym Gene Names
UniProt Comments for Pip5k1c
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transport, cell adhesion, cell polarization and cell migration. Together with PIP5K1A is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport. Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis. Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2). Required for clathrin-coated pits assembly at the synapse. Participates in cell junction assembly. Modulates adherens junctions formation by facilitating CDH1 trafficking. Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions. Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins. Required for uropodium formation and retraction of the cell rear during directed migration. Has a role in growth factor- stimulated directional cell migration and adhesion. Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor. Negative regulator of T-cell activation and adhesion. Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor. Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth ().
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Pathways associated with Pip5k1c recombinant protein
Products by Pathway |
Pathway Diagram |
Axon Guidance Pathway antibodies |
Axon Guidance Pathway Diagram |
B Cell Receptor Signaling Pathway antibodies |
B Cell Receptor Signaling Pathway Diagram |
Developmental Biology Pathway antibodies |
Developmental Biology Pathway Diagram |
Endocytosis Pathway antibodies |
Endocytosis Pathway Diagram |
Endocytosis Pathway antibodies |
Endocytosis Pathway Diagram |
Fc Gamma R-mediated Phagocytosis Pathway antibodies |
Fc Gamma R-mediated Phagocytosis Pathway Diagram |
Fc Gamma R-mediated Phagocytosis Pathway antibodies |
Fc Gamma R-mediated Phagocytosis Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram |
Diseases associated with Pip5k1c recombinant protein
Organs/Tissues associated with Pip5k1c recombinant protein
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