NP_446378.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Related Accession #
Molecular Weight
46,210 Da
NCBI Official Full Name
phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
NCBI Official Synonym Full Names
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
NCBI Official Synonym Symbols
NCBI Protein Information
phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
UniProt Protein Name
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
UniProt Synonym Protein Names
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha; PIPK2 alpha; Phosphatidylinositol 5-phosphate 4-kinase type II alpha; PI(5)P 4-kinase type II alpha; PIP4KII-alpha; PtdIns(5)P-4-kinase isoform 2-alpha
UniProt Synonym Gene Names
NCBI Summary for Pip4k2a
mouse homolog is kinase which catalyzes the synthesis of phosphatidylinositol 4, 5-bisphosphate, an essential lipid molecule in various cellular processes [RGD, Feb 2006]
UniProt Comments for Pip4k2a
Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May be involved in thrombopoiesis and the terminal maturation of megakaryocytes and regulation of their size (). May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with Pip4k2a recombinant protein
Diseases associated with Pip4k2a recombinant protein
Organs/Tissues associated with Pip4k2a recombinant protein
|