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PFKM recombinant protein :: Phosphofructokinase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144030 PFKM recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phosphofructokinase (PFKM), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Phosphofructokinase, Muscle

 Product Synonym Names    PFKM Human; Phosphofructokinase, Muscle Human Recombinant; EC 2.7.1.11; GSD7; PFK-1; PFK1; PFKA; PFKX; Phosphofructokinase-M; Phosphofructokinase 1; Phosphohexokinase; Phosphofructo-1-kinase isozyme A; MGC8699; PFKM
 Product Gene Name   

PFKM recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MTHEEHHAAK TLGIGKAIAV LTSGGDAQGM NAAVRAVVRV GIFTGARVFF VHEGYQGLVD GGDHIKEATW ESVSMMLQLG GTVIGSARCK DFREREGRLR AAYNLVKRGI TNLCVIGGDG SLTGADTFRS EWSDLLSDLQ KAGKITDEEA TKSSYLNIVG LVGSIDNDFC GTDMTIGTDS ALHRIMEIVD AITTTAQSHQ RTFVLEVMGR HCGYLALVTS LSCGADWVFI PECPPDDDWE EHLCRRLSET RTRGSRLNII IVAEGAIDKN GKPITSEDIK NLVVKRLGYD TRVTVLGHVQ RGGTPSAFDR ILGSRMGVEA VMALLEGTPD TPACVVSLSG NQAVRLPLME CVQVTKDVTK AMDEKKFDEA LKLRGRSFMN NWEVYKLLAH VRPPVSKSGS HTVAVMNVGA PAAGMNAAVR STVRIGLIQG NRVLVVHDGF EGLAKGQIEE AGWSYVGGWT GQGGSKLGTK RTLPKKSFEQ ISANITKFNI QGLVIIGGFE AYTGGLELME GRKQFDELCI PFVVIPATVS NNVPGSDFSV GADTALNTIC TTCDRIKQSA AGTKRRVFII ETMGGYCGYL ATMAGLAAGA DAAYIFEEPF TIRDLQANVE HLVQKMKTTV KRGLVLRNEK CNENYTTDFI FNLYSEEGKG IFDSRKNVLG HMQQGGSPTP FDRNFATKMG AKAMNWMSGK IKESYRNGRI FANTPDSGCV LGMRKRALVF QPVAELKDQT DFEHRIPKEQ WWLKLRPILK ILAKYEIDLD TSDHAHLEHI TRKRSGEAAV
 OMIM    232800
 3D Structure    ModBase 3D Structure for P08237
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 Host    E Coli
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 Purity/Purification    Greater than 80% as determined by SDS-PAGE.
 Form/Format    PFKM Human solution (0.5mg/ml) containing 20mM Trsi HCL pH-8, 5mM DTT, 0.2M NaCl and 20% glycerol.
Sterile filtered colorless solution.
 Concentration    0.5 mg/ml (lot specific)
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 Preparation and Storage    PFKM human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.
 Other Notes    Small volumes of PFKM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PFKM recombinant protein

   Description: PFKM Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 800 amino acids (1-780 a.a.) and having a molecular mass of 87.3 kDa. PFKM protein is fused to a 20 amino acid His-Tag at N-terminus and purified by standard chromatography.

Introduction: PFKM is a regulatory glycolytic enzyme that converts fructose 6-phosphate and ATP into fructose 1,6-bisphosphate (through PFK-1), fructose 2,6-bisphosphate (through PFK-2) and ADP. Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. Mutations in PFKM gene have been related with glycogen storage disease type VII, also identified as Tarui disease.
 Product Categories/Family for PFKM recombinant protein    PROTEIN KINASES; Enzymes; Protein Kinases
NCBI/Uniprot data below describe general gene information for PFKM. It may not necessarily be applicable to this product.
 NCBI GI #    4505749
 NCBI GeneID    5213
 NCBI Accession #    NP_000280.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000289.5 [Other Products]
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 UniProt Primary Accession #    P08237 [Other Products]
 UniProt Secondary Accession #    Q16814; Q16815; Q6ZTT1; J3KNX3 [Other Products]
 UniProt Related Accession #    P08237 [Other Products]
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 NCBI Official Full Name    ATP-dependent 6-phosphofructokinase, muscle type isoform 2
 NCBI Official Synonym Full Names    phosphofructokinase, muscle
 NCBI Official Symbol    PFKM [Similar Products]
 NCBI Official Synonym Symbols   
GSD7; PFK1; PFKA; PFKX; PFK-1; ATP-PFK; PPP1R122
[Similar Products]
 NCBI Protein Information    ATP-dependent 6-phosphofructokinase, muscle type; 6-phosphofructo-1-kinase; 6-phosphofructokinase type A; ATP-PFK; PFK-A; phosphofructo-1-kinase isozyme A; phosphofructokinase 1; phosphofructokinase, polypeptide X; phosphofructokinase-M; phosphohexokinase; protein phosphatase 1, regulatory subunit 122
 UniProt Protein Name    ATP-dependent 6-phosphofructokinase, muscle type
 UniProt Synonym Protein Names   
6-phosphofructokinase type APhosphofructo-1-kinase isozyme A
 Protein Family    ATP-dependent 6-phosphofructokinase
 UniProt Gene Name    PFKM [Similar Products]
 UniProt Synonym Gene Names    ; PFK-M [Similar Products]
 UniProt Entry Name    PFKAM_HUMAN
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 NCBI Summary for PFKM    Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
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 UniProt Comments for PFKM    PFKM: phosphofructokinase, muscle type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts. Defects in PFKM are the cause of glycogen storage disease VII (GSD-VII) also known as Tarui disease. Two alternatively spliced isoforms have been described.

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - fructose and mannose; Kinase, other; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: 6-phosphofructokinase complex; apical plasma membrane; cytosol

Molecular Function: protein C-terminus binding; identical protein binding; protein binding; protein homodimerization activity; metal ion binding; kinase binding; ATP binding; 6-phosphofructokinase activity

Biological Process: muscle maintenance; glycolysis; carbohydrate metabolic process; carbohydrate phosphorylation; glucose metabolic process; positive regulation of insulin secretion; pathogenesis; fructose 6-phosphate metabolic process; glucose homeostasis; protein oligomerization

Disease: Glycogen Storage Disease Vii
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 Research Articles on PFKM    1. Gene-based analysis identified an association between breast cancer and the phosphofructokinase-muscle (PFKM) gene on chromosome 12q13.11 that met the genome-wide gene-based threshold of 2.5 x 10(-6).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PFKM recombinant proteinPathways associated with PFKM recombinant protein
 Reference Product  PubMed Publications
 PFKL recombinant protein  >7 publications with PFKM and PFKL
 HK2 recombinant protein  >2 publications with PFKM and HK2
 GPI recombinant protein  >2 publications with PFKM and GPI
 PFKFB1 recombinant protein  >1 publications with PFKM and PFKFB1
 HK1 recombinant protein  >1 publications with PFKM and HK1
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
Diseases associated with PFKM recombinant proteinOrgans/Tissues associated with PFKM recombinant protein
 Disease Name  Pubmed Publications
 Glycogen Storage Disease Type VII Antibodies  >46 publications with PFKM and Glycogen Storage Disease Type VII
 Anemia Antibodies  >17 publications with PFKM and Anemia
 Cardiovascular Diseases Antibodies  >13 publications with PFKM and Cardiovascular Diseases
 Liver Diseases Antibodies  >12 publications with PFKM and Liver Diseases
 Heart Diseases Antibodies  >10 publications with PFKM and Heart Diseases
 Disease Models, Animal Antibodies  >8 publications with PFKM and Disease Models, Animal
 Mitochondrial Diseases Antibodies  >7 publications with PFKM and Mitochondrial Diseases
 Hypertrophy Antibodies  >6 publications with PFKM and Hypertrophy
 Diabetes Mellitus, Experimental Antibodies  >4 publications with PFKM and Diabetes Mellitus, Experimental
 Liver Neoplasms Antibodies  >3 publications with PFKM and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >273 publications with PFKM and Muscle
 Blood Antibodies  >80 publications with PFKM and Blood
 Liver Antibodies  >65 publications with PFKM and Liver
 Heart Antibodies  >35 publications with PFKM and Heart
 Brain Antibodies  >28 publications with PFKM and Brain
 Nerve Antibodies  >12 publications with PFKM and Nerve
 Kidney Antibodies  >11 publications with PFKM and Kidney
 Testis Antibodies  >10 publications with PFKM and Testis
 Skin Antibodies  >8 publications with PFKM and Skin
 Vascular Antibodies  >7 publications with PFKM and Vascular
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