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PGD recombinant protein :: Phosphogluconate Dehydrogenase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144031 PGD recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phosphogluconate Dehydrogenase (PGD), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Phosphogluconate Dehydrogenase

 Product Synonym Names    PGD Human; Phosphogluconate Dehydrogenase Human Recombinant; EC 1.1.1.44; 6PGD; PGDH; 6-phosphogluconate dehydrogenase decarboxylating; PGD
 Product Gene Name   

PGD recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVVGAQSLKE MVSKLKKPRR IILLVKAGQA VDDFIEKLVP LLDTGDIIID GGNSEYRDTT RRCRDLKAKG ILFVGSGVSG GEEGARYGPS LMPGGNKEAW PHIKTIFQGI AAKVGTGEPC CDWVGDEGAG HFVKMVHNGI EYGDMQLICE AYHLMKDVLG MAQDEMAQAF EDWNKTELDS FLIEITANIL KFQDTDGKHL LPKIRDSAGQ KGTGKWTAIS ALEYGVPVTL IGEAVFARCL SSLKDERIQA SKKLKGPQKF QFDGDKKSFL EDIRKALYAS KIISYAQGFM LLRQAATEFG WTLNYGGIAL MWRGGCIIRS VFLGKIKDAF DRNPELQNLL LDDFFKSAVE NCQDSWRRAV STGVQAGIPM PCFTTALSFY DGYRHEMLPA SLIQAQRDYF GAHTYELLAK PGQFIHTNWT GHGGTVSSSS YNA
 OMIM    172200
 3D Structure    ModBase 3D Structure for P52209
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    The PGD solution contains 20mM Tris-HCl pH-8, 1mM DTT, 0.1M NaCl and 10% glycerol.
Sterile Filtered clear colorless solution.
 Concentration    25ug/25ul (lot specific)
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 Preparation and Storage    PGD Recombinant Human although stable at 4 degree C for 30 days, should be stored desiccated below -20 degree C for periods greater than 30 days. Please avoid freeze-thaw cycles.
 Other Notes    Small volumes of PGD recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PGD recombinant protein

   Description: PGD Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 503 amino acids (1-483 a.a.) and having a molecular mass of 55.3 kDa. The PGD is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: 6PGD is the second dehydrogenase in the pentose phosphate shunt. Pentose is neccesary for nucleic acid biosynthesis. The pentose phosphate cycle is a major source of NADPH 6PGD deficiency is usually asymptomatic, and the inheritance of this disorder is autosomal dominant. PGD deficiency raises the erythrocyte pyruvate kinase levels of activity and decreases glutathione synthetase, resulting in hemolysis.
 Product Categories/Family for PGD recombinant protein    ENZYMES; Enzymes; Dehydrogenase
NCBI/Uniprot data below describe general gene information for PGD. It may not necessarily be applicable to this product.
 NCBI GI #    40068518
 NCBI GeneID    5226
 NCBI Accession #    NP_002622.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002631.3 [Other Products]
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 UniProt Primary Accession #    P52209 [Other Products]
 UniProt Secondary Accession #    Q9BWD8; A8K2Y9; B4DQJ8 [Other Products]
 UniProt Related Accession #    P52209 [Other Products]
 Molecular Weight    51,872 Da
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 NCBI Official Full Name    6-phosphogluconate dehydrogenase, decarboxylating isoform 1
 NCBI Official Synonym Full Names    phosphogluconate dehydrogenase
 NCBI Official Symbol    PGD [Similar Products]
 NCBI Official Synonym Symbols   
6PGD
[Similar Products]
 NCBI Protein Information    6-phosphogluconate dehydrogenase, decarboxylating
 UniProt Protein Name    6-phosphogluconate dehydrogenase, decarboxylating
 UniProt Gene Name    PGD [Similar Products]
 UniProt Synonym Gene Names    PGDH [Similar Products]
 UniProt Entry Name    6PGD_HUMAN
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 NCBI Summary for PGD    6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
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 UniProt Comments for PGD    PGD: an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways.

Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 1.1.1.44; Oxidoreductase; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: cytosol; nucleus

Molecular Function: phosphogluconate dehydrogenase (decarboxylating) activity; NADP binding

Biological Process: pentose-phosphate shunt; pentose-phosphate shunt, oxidative branch; carbohydrate metabolic process; pathogenesis; D-gluconate metabolic process; pentose biosynthetic process
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 Research Articles on PGD    1. Results show that 6PGD activity is upregulated with increased lysine acetylation in primary leukemia cells from human patients, providing mechanistic insights into 6PGD upregulation in cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PGD recombinant proteinPathways associated with PGD recombinant protein
 Reference Product  PubMed Publications
 GPI recombinant protein  >62 publications with PGD and GPI
 G6PD recombinant protein  >57 publications with PGD and G6PD
 MDH2 recombinant protein  >7 publications with PGD and MDH2
 RPE recombinant protein  >4 publications with PGD and RPE
 TKT recombinant protein  >3 publications with PGD and TKT
 FUCA1 recombinant protein  >1 publications with PGD and FUCA1
 TALDO1 recombinant protein  >1 publications with PGD and TALDO1
 RPIA recombinant protein  >1 publications with PGD and RPIA
 H6PD recombinant protein  >1 publications with PGD and H6PD
 Products by Pathway  Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Myoclonic Epilepsy Of Lafora Pathway antibodies  Myoclonic Epilepsy Of Lafora Pathway Diagram
Diseases associated with PGD recombinant proteinOrgans/Tissues associated with PGD recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >258 publications with PGD and Nervous System Diseases
 Inflammation Antibodies  >236 publications with PGD and Inflammation
 Brain Diseases Antibodies  >119 publications with PGD and Brain Diseases
 Infertility, Male Antibodies  >100 publications with PGD and Infertility, Male
 Anemia Antibodies  >100 publications with PGD and Anemia
 Fibrosis Antibodies  >98 publications with PGD and Fibrosis
 Heart Diseases Antibodies  >50 publications with PGD and Heart Diseases
 Necrosis Antibodies  >49 publications with PGD and Necrosis
 Kidney Diseases Antibodies  >43 publications with PGD and Kidney Diseases
 Hypertension Antibodies  >35 publications with PGD and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >732 publications with PGD and Blood
 Lung Antibodies  >244 publications with PGD and Lung
 Brain Antibodies  >177 publications with PGD and Brain
 Heart Antibodies  >126 publications with PGD and Heart
 Vascular Antibodies  >116 publications with PGD and Vascular
 Bone Antibodies  >105 publications with PGD and Bone
 Muscle Antibodies  >91 publications with PGD and Muscle
 Bone Marrow Antibodies  >80 publications with PGD and Bone Marrow
 Uterus Antibodies  >78 publications with PGD and Uterus
 Skin Antibodies  >76 publications with PGD and Skin
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