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PHPT1 recombinant protein :: Phosphohistidine Phosphatase 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144317 PHPT1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phosphohistidine Phosphatase 1 (PHPT1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Phosphohistidine Phosphatase 1

 Product Synonym Names    PHPT1 Human; Phosphohistidine Phosphatase 1 Human Recombinant; PHP14; CGI-202; HSPC141; Phosphohistidine Phosphatase 1; Phosphohistidine Phosphatase 14kDa; Protein janus-A homolog; Sex-regulated protein Janus-a
 Product Gene Name   

PHPT1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610167
 3D Structure    ModBase 3D Structure for Q9NRX4
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 Host    E Coli
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    The PHPT1 protein solution (0.5mg/1ml) is formulated in 20 mM Tris-HCl buffer (pH8.0) 0.2M NaCl, 2mM DTT and 10% glycerol.
Sterile Filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protien (0.1% HSA or BSA).Please avoid freeze thaw cycles.
 Other Notes    Small volumes of PHPT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PHPT1 recombinant protein

   Description: PHPT1 produced in E Coli is a single, non-glycosylated polypeptide chain containing 145 amino acids (1-125a.a.) and having a molecular mass of 15.9kDa.PHPT1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: PHPT1 is a member of the Janus protein familyand is 125 amino acid long. PHPT1 appears as a monomer in the cytoplasm and is an EDTA-insensitive phosphohistidine phosphatase. Overexpression of PHPT1 resolts in specific phosphohistidine phosphatase activity towards phosphopeptide I, with no activity detected towards phosphotyrosine, phosphothreonine and phosphoserine peptides.
 Product Categories/Family for PHPT1 recombinant protein    ENZYMES; Enzymes; Phosphatase
NCBI/Uniprot data below describe general gene information for PHPT1. It may not necessarily be applicable to this product.
 NCBI GI #    209529723
 NCBI GeneID    29085
 NCBI Accession #    NP_001129333.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135861.2 [Other Products]
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 UniProt Primary Accession #    Q9NRX4 [Other Products]
 UniProt Secondary Accession #    Q9H0Y3; B1AMX0; B1AMX1 [Other Products]
 UniProt Related Accession #    Q9NRX4 [Other Products]
 Molecular Weight    13,672 Da
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 NCBI Official Full Name    14 kDa phosphohistidine phosphatase isoform 2
 NCBI Official Synonym Full Names    phosphohistidine phosphatase 1
 NCBI Official Symbol    PHPT1 [Similar Products]
 NCBI Official Synonym Symbols   
PHP14; CGI-202; HSPC141; HEL-S-132P
[Similar Products]
 NCBI Protein Information    14 kDa phosphohistidine phosphatase; epididymis secretory sperm binding protein Li 132P; protein janus-A homolog; sex-regulated protein janus-a
 UniProt Protein Name    14 kDa phosphohistidine phosphatase
 UniProt Synonym Protein Names   
Phosphohistidine phosphatase 1; Protein janus-A homolog
 Protein Family    14 kDa phosphohistidine phosphatase
 UniProt Gene Name    PHPT1 [Similar Products]
 UniProt Synonym Gene Names    PHP14 [Similar Products]
 UniProt Entry Name    PHP14_HUMAN
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 NCBI Summary for PHPT1    This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
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 UniProt Comments for PHPT1    PHPT1: a phosphohistidine phosphatase. Present preferentially in heart and skeletal muscle. Insensitive to inhibition by okadaic acid and EDTA.

Protein type: Motility/polarity/chemotaxis; Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.-; Carbohydrate Metabolism - fructose and mannose; Phosphatase; Cofactor and Vitamin Metabolism - riboflavin

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cytosol

Molecular Function: phosphohistidine phosphatase activity; calcium channel inhibitor activity; phosphoprotein phosphatase activity

Biological Process: negative regulation of lyase activity; negative regulation of T cell receptor signaling pathway; protein amino acid dephosphorylation
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 Research Articles on PHPT1    1. the histidine phosphatase, protein histidine phosphatase 1, inhibits NDPK-B-activated TRPV5 in inside/out patch experiments.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PHPT1 recombinant proteinPathways associated with PHPT1 recombinant protein
 Reference Product  PubMed Publications
 KCNN4 recombinant protein  >2 publications with PHPT1 and KCNN4
 Products by Pathway  Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
Diseases associated with PHPT1 recombinant proteinOrgans/Tissues associated with PHPT1 recombinant protein
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >2 publications with PHPT1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with PHPT1 and Carcinoma, Hepatocellular
 Neoplasm Metastasis Antibodies  >1 publications with PHPT1 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with PHPT1 and Blood
 Pancreas Antibodies  >2 publications with PHPT1 and Pancreas
 Liver Antibodies  >2 publications with PHPT1 and Liver
 Lung Antibodies  >2 publications with PHPT1 and Lung
 Heart Antibodies  >2 publications with PHPT1 and Heart
 Muscle Antibodies  >2 publications with PHPT1 and Muscle
 Kidney Antibodies  >1 publications with PHPT1 and Kidney
 Intestine Antibodies  >1 publications with PHPT1 and Intestine
 Lymph Node Antibodies  >1 publications with PHPT1 and Lymph Node
 Testis Antibodies  >1 publications with PHPT1 and Testis
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