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PSPH recombinant protein :: Phosphoserine Phosphatase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142770 PSPH recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,750 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Phosphoserine Phosphatase (PSPH), Recombinant Protein

 Also Known As   

Recombinant Human Phosphoserine Phosphatase

 Product Synonym Names    PSPH Human; Phosphoserine Phosphatase Human Recombinant; Phosphoserine phosphatase; EC 3.1.3.3; PSP; O-phosphoserine phosphohydrolase; PSPase; L-3-phosphoserine phosphatase; PSPH
 Product Gene Name   

PSPH recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MVSHSELRKL FYSADAVCFD VDSTVIREEG IDELAKICGV EDAVSEMTRR AMGGAVPFKA ALTERLALIQ PSREQVQRLI AEQPPHLTPG IRELVSRLQE RNVQVFLISG GFRSIVEHVA SKLNIPATNV FANRLKFYFN GEYAGFDETQ PTAESGGKGK VIKLLKEKFH FKKIIMIGDG ATDMEACPPA DAFIGFGGNV IRQQVKDNAK WYITDFVELL GELEE
 OMIM    172480
 3D Structure    ModBase 3D Structure for P78330
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by(a)Analysis by RP-HPLC. (b)Analysis by SDS-PAGE.
 Form/Format    The protein contains 20mM Hepes pH 7.5, 1mM DTT &100mM KCl2.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of PSPH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PSPH recombinant protein

   Description: Phosphoserine Phosphatase Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids and having a molecular mass of 25 kDa. PSP was overexpressed in E Coli and purified by conventional chromatography.

Introduction: Human Phosphoserine phosphatase (hPSP) is an important enzyme in the phosphorylated pathway of serine biosynthesis, which contributes a major portion of the endogenous L-serine. Similar to known L-3-phosphoserine phosphatases, it catalyzed the Mg2+-dependent hydrolysis of L-phosphoserine and an exchange reaction between L-serine and L-phosphoserine. Recently, its complex structures reveal that the open-closed environmental change of the active site, generated -helical bundle domain, is important to substrate by local rearrangement of the recognition and hydrolysis.
 Product Categories/Family for PSPH recombinant protein    PROTEIN KINASES; Enzymes; Phosphatase
NCBI/Uniprot data below describe general gene information for PSPH. It may not necessarily be applicable to this product.
 NCBI GI #    46249388
 NCBI GeneID    5723
 NCBI Accession #    NP_004568.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004577.3 [Other Products]
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 UniProt Primary Accession #    P78330 [Other Products]
 UniProt Secondary Accession #    Q7Z3S5; B2RCR5 [Other Products]
 UniProt Related Accession #    P78330 [Other Products]
 Molecular Weight    25,008 Da
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 NCBI Official Full Name    phosphoserine phosphatase
 NCBI Official Synonym Full Names    phosphoserine phosphatase
 NCBI Official Symbol    PSPH [Similar Products]
 NCBI Official Synonym Symbols   
PSP; PSPHD
[Similar Products]
 NCBI Protein Information    phosphoserine phosphatase; L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; PSPase
 UniProt Protein Name    Phosphoserine phosphatase
 UniProt Synonym Protein Names   
L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase
 Protein Family    Phosphoserine phosphatase
 UniProt Gene Name    PSPH [Similar Products]
 UniProt Synonym Gene Names    PSP; PSPase [Similar Products]
 UniProt Entry Name    SERB_HUMAN
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 NCBI Summary for PSPH    The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PSPH    PSPH: Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome. Belongs to the SerB family.

Protein type: EC 3.1.3.3; Motility/polarity/chemotaxis; Hydrolase; Amino Acid Metabolism - glycine, serine and threonine

Chromosomal Location of Human Ortholog: 7p11.2

Cellular Component: neuron projection; cytoplasm; cytosol

Molecular Function: protein homodimerization activity; phosphoserine phosphatase activity; magnesium ion binding; calcium ion binding

Biological Process: response to nutrient levels; L-serine biosynthetic process; dephosphorylation; L-serine metabolic process; response to mechanical stimulus; response to testosterone stimulus; amino acid biosynthetic process

Disease: Phosphoserine Phosphatase Deficiency
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 Research Articles on PSPH    1. phosphoserine phosphatase deficiency is associated with Neu-Laxova syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PSPH recombinant proteinPathways associated with PSPH recombinant protein
 Reference Product  PubMed Publications
 PSAT1 recombinant protein  >7 publications with PSPH and PSAT1
 SHMT1 recombinant protein  >6 publications with PSPH and SHMT1
 CBS recombinant protein  >1 publications with PSPH and CBS
 SHMT2 recombinant protein  >1 publications with PSPH and SHMT2
 Products by Pathway  Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
Diseases associated with PSPH recombinant proteinOrgans/Tissues associated with PSPH recombinant protein
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >4 publications with PSPH and Breast Neoplasms
 Hypertension Antibodies  >2 publications with PSPH and Hypertension
 Heart Diseases Antibodies  >2 publications with PSPH and Heart Diseases
 Cardiovascular Diseases Antibodies  >2 publications with PSPH and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >1 publications with PSPH and Lung Neoplasms
 Fetal Growth Retardation Antibodies  >1 publications with PSPH and Fetal Growth Retardation
 Fatty Liver Antibodies  >1 publications with PSPH and Fatty Liver
 Hyperplasia Antibodies  >1 publications with PSPH and Hyperplasia
 Neural Tube Defects Antibodies  >1 publications with PSPH and Neural Tube Defects
 Inflammation Antibodies  >1 publications with PSPH and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with PSPH and Blood
 Lung Antibodies  >6 publications with PSPH and Lung
 Brain Antibodies  >6 publications with PSPH and Brain
 Liver Antibodies  >3 publications with PSPH and Liver
 Bone Antibodies  >2 publications with PSPH and Bone
 Mouth Antibodies  >1 publications with PSPH and Mouth
 Vascular Antibodies  >1 publications with PSPH and Vascular
 Lymph Node Antibodies  >1 publications with PSPH and Lymph Node
 Skin Antibodies  >1 publications with PSPH and Skin
 Eye Antibodies  >1 publications with PSPH and Eye
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