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PEDF recombinant protein :: Pigment Epithelium-Derived Factor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143338 PEDF recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,165 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pigment Epithelium-Derived Factor (PEDF), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Pigment Epithelium-Derived Factor, HEK

 Product Synonym Names    PEDF Human, HEK; Pigment Epithelium-Derived Factor Human Recombinant, HEK; Pigment epithelium-derived factor; PEDF; Serpin-F1; SerpinF1; EPC-1; EPC1; PIG35; PEDF HEK
 Product Gene Name   

PEDF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    QNPASPPEEG SPDPDSTGAL VEEEDPFFKV PVNKLAAAVS NFGYDLYRVR SSTSPTTNVL LSPLSVATAL SALSLGAEQR TESIIHRALY YDLISSPDIH GTYKELLDTV TAPQKNLKSA SRIVFEKKLR IKSSFVAPLE KSYGTRPRVL TGNPRLDLQE INNWVQAQMK GKLARSTKEI PDEISILLLG VAHFKGQWVT KFDSRKTSLE DFYLDEERTV RVPMMSDPKA VLRYGLDSDL SCKIAQLPLT GSMSIIFFLP LKVTQNLTLI EESLTSEFIH DIDRELKTVQ AVLTVPKLKL SYEGEVTKSL QEMKLQSLFD SPDFSKITGK PIKLTQVEHR AGFEWNEDGA GTTPSPGLQP AHLTFPLDYH LNQPFIFVLR DTDTGALLFI GKILDPRGPA AADYKDDDDK
 OMIM    172860
 3D Structure    ModBase 3D Structure for P36955
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 Host    HEK 293
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 Purity/Purification    Greater than 95% as determined by SDS-PAGE.
 Form/Format    The filtered (0.4 um) concentrated (0.5mg/ml) protein solution was lyophilized with 20mM Tris & 20mM NaCl pH-7.5.
Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recomnded to add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
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 Preparation and Storage    Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time.
 Other Notes    Small volumes of PEDF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PEDF recombinant protein

   Description: PEDF Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing a total of 410 amino acids, having a molecular mass of 45.6 kDa and fused to an 11 aa FLAG tag at C-Terminus.The Human PEDF is purified by proprietary chromatographic techniques.

Introduction: PEDF is a neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. SerpinF1 is a potent inhibitor of angiogenesis. EPC1 doesn't undergo the stressed to relaxed conformation transition characteristic as of the active serpins since it exhibits no serine protease inhibitory activity.Aqueous humour level of asymmetric dimethylarginine is correlated with PEDF in humans. ADMA and PEDF levels are increased in response to inflammation in uveitis.Lack of PEDF expression is a potent factor for the enhancement of tumor growth and angiogenesis in breast cancer.PEDF & VEGF genes contribute to the development of diabetic retinopathy.PEDF and VEGF structural changes in blood vessel wall play an important role in the pathophysiology of PD patients.PEDF-overexpressing tumors exhibited reduced intratumoral angiogenesis.SerpinF1 is a new promising approach for the treatment of osteosarcoma. Levels of the natural ocular anti-angiogenic factor SentrinF1 (PEDF) is associated with proliferative retinopathy.VEGF secreted by retinal pigment epithelial cells upregulates PEDF expression via VEGFR-1 in an autocrine manner. Sentrin-F1 concentration in the aqueous humor of diabetic patients predicts who will develop progression of retinopathy.PEDF blocks angiogenic effects of leptin through its anti-oxidative properties.
 Product Categories/Family for PEDF recombinant protein    CYTOKINES AND GROWTH FACTORS; Neurotrophins; Pigment Epithelium-Derived Factor
NCBI/Uniprot data below describe general gene information for PEDF. It may not necessarily be applicable to this product.
 NCBI GI #    39725934
 NCBI GeneID    5176
 NCBI Accession #    NP_002606.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002615.5 [Other Products]
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 UniProt Primary Accession #    P36955 [Other Products]
 UniProt Secondary Accession #    Q13236; Q2TU83; Q96CT1; Q96R01; Q9BWA4; F1T092 [Other Products]
 UniProt Related Accession #    P36955 [Other Products]
 Molecular Weight    46,312 Da
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 NCBI Official Full Name    pigment epithelium-derived factor
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
 NCBI Official Symbol    SERPINF1 [Similar Products]
 NCBI Official Synonym Symbols   
OI6; OI12; PEDF; EPC-1; PIG35
[Similar Products]
 NCBI Protein Information    pigment epithelium-derived factor; cell proliferation-inducing gene 35 protein; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serpin F1
 UniProt Protein Name    Pigment epithelium-derived factor
 UniProt Synonym Protein Names   
Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1
 Protein Family    Pigment epithelium-derived factor
 UniProt Gene Name    SERPINF1 [Similar Products]
 UniProt Synonym Gene Names    PEDF; PEDF [Similar Products]
 UniProt Entry Name    PEDF_HUMAN
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 NCBI Summary for PEDF    The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]
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 UniProt Comments for PEDF    PEDF: a secreted neurotrophic protein that induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Extracellular phosphorylation enhances antiangiogenic activity.

Protein type: Secreted; Inhibitor; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: axon hillock; extracellular matrix; extracellular space; perinuclear region of cytoplasm; extracellular region; melanosome; basement membrane

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: cell proliferation; positive regulation of neurogenesis; negative regulation of angiogenesis; ovulation cycle; retina development in camera-type eye; short-term memory; negative regulation of inflammatory response; multicellular organismal development; response to arsenic; response to acidity; kidney development; aging

Disease: Osteogenesis Imperfecta, Type Vi
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 Research Articles on PEDF    1. PEDF is anti-angiogenic and is associated with the growth inhibition of hemangioma-derived endothelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PEDF recombinant proteinDiseases associated with PEDF recombinant protein
 Reference Product  PubMed Publications
 VEGFA recombinant protein  >2 publications with PEDF and VEGFA
 YWHAE recombinant protein  >1 publications with PEDF and YWHAE
 A2M recombinant protein  >1 publications with PEDF and A2M
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with PEDF and Nervous System Diseases
 Proteinuria Antibodies  >1 publications with PEDF and Proteinuria
 Brain Diseases Antibodies  >1 publications with PEDF and Brain Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with PEDF and Urinary Bladder Neoplasms
 Lung Neoplasms Antibodies  >1 publications with PEDF and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with PEDF and Cell Transformation, Neoplastic
 Weight Loss Antibodies  >1 publications with PEDF and Weight Loss
Organs/Tissues associated with PEDF recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >22 publications with PEDF and Bone
 Nerve Antibodies  >21 publications with PEDF and Nerve
 Eye Antibodies  >19 publications with PEDF and Eye
 Connective Tissue Antibodies  >9 publications with PEDF and Connective Tissue
 Blood Antibodies  >6 publications with PEDF and Blood
 Skin Antibodies  >5 publications with PEDF and Skin
 Adipose Tissue Antibodies  >5 publications with PEDF and Adipose Tissue
 Brain Antibodies  >5 publications with PEDF and Brain
 Embryonic Tissue Antibodies  >3 publications with PEDF and Embryonic Tissue
 Lung Antibodies  >2 publications with PEDF and Lung
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