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PLAP recombinant protein :: Placental Alkaline Phosphatase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142474 PLAP recombinant protein
Unit / Price
0.002 mg  /  $265 +1 FREE 8GB USB
0.005 mg  /  $365 +1 FREE 8GB USB
0.01 mg  /  $610 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Placental Alkaline Phosphatase (PLAP), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Placental Alkaline Phosphatase

 Product Synonym Names    PLAP Human; Placental Alkaline Phosphatase Human Recombinant; ALP; PLAP; Alkaline phosphatase placental type; EC 3.1.3.1; PLAP-1; Alkaline phosphatase Regan isozyme
 Product Gene Name   

PLAP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    171800
 3D Structure    ModBase 3D Structure for P05187
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 Host    E Coli
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 Form/Format    PLAP in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Sterile filtered liquid.
 Concentration    100ug/ml (lot specific)
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 Preparation and Storage    Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of PLAP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PLAP recombinant protein

   Description: Placental Alkaline Phosphatase Human Recombinant encoding 154-287 amino acids expressed in E Coli, shows a 41kDa band on SDS-PAGE (including GST tag).PLAP Human Recombinant is purified by proprietary chromatographic techniques.

Introduction: Placental alkaline phosphatase (PLAP) is a membrane-associated siaglycoprotein enzyme normally present at high concentration in syncytiotrophoblasts within the placenta during the third trimester of gestation. The expression of PLAP was originally thought to be restricted to term placenta but a human PLAP-like variant has been described which shares more than 85% homology with PLAP itself. PLAP is expressed only in normal term placenta, endocervix and fallopian tube and also in ovarian and proximal gastrointestinal tumors. It is also commonly expressed in germ cell tumors and more recently described in seminomas.
 Product Categories/Family for PLAP recombinant protein    ENZYMES; Enzymes; Phosphatase
NCBI/Uniprot data below describe general gene information for PLAP. It may not necessarily be applicable to this product.
 NCBI GI #    94721246
 NCBI GeneID    250
 NCBI Accession #    NP_001623.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001632.4 [Other Products]
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 UniProt Primary Accession #    P05187 [Other Products]
 UniProt Secondary Accession #    P05188; P06861; Q53S78; Q96DB7 [Other Products]
 UniProt Related Accession #    P05187 [Other Products]
 Molecular Weight    57,954 Da
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 NCBI Official Full Name    alkaline phosphatase, placental type preproprotein
 NCBI Official Synonym Full Names    alkaline phosphatase, placental
 NCBI Official Symbol    ALPP [Similar Products]
 NCBI Official Synonym Symbols   
ALP; PALP; PLAP; PLAP-1
[Similar Products]
 NCBI Protein Information    alkaline phosphatase, placental type; alkaline phosphatase Regan isozyme; alkaline phosphomonoesterase; glycerophosphatase; placental alkaline phosphatase 1
 UniProt Protein Name    Alkaline phosphatase, placental type
 UniProt Synonym Protein Names   
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1
 Protein Family    Probable low-affinity putrescine importer
 UniProt Gene Name    ALPP [Similar Products]
 UniProt Synonym Gene Names    PLAP; PLAP-1 [Similar Products]
 UniProt Entry Name    PPB1_HUMAN
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 NCBI Summary for PLAP    The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]
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 UniProt Comments for PLAP    ALPP: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, GPI anchor; Phosphatase (non-protein); Motility/polarity/chemotaxis; EC 3.1.3.1; Cell surface; Cofactor and Vitamin Metabolism - folate biosynthesis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: cell surface; plasma membrane; integral to membrane

Molecular Function: alkaline phosphatase activity; zinc ion binding; magnesium ion binding

Biological Process: dephosphorylation
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 Research Articles on PLAP    1. Anti-PLAP antibodies may serve as a modular building blocks for the development of targeted therapeutic products, armed with cytotoxic drugs, radionuclides or cytokines as payloads.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PLAP recombinant proteinPathways associated with PLAP recombinant protein
 Reference Product  PubMed Publications
 PTS recombinant protein  >1 publications with PLAP and PTS
 Products by Pathway  Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Pyridoxal 5'-phosphate Salvage Pathway antibodies  Pyridoxal 5'-phosphate Salvage Pathway Diagram
Diseases associated with PLAP recombinant proteinOrgans/Tissues associated with PLAP recombinant protein
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >27 publications with PLAP and Adenocarcinoma
 Pregnancy Complications Antibodies  >23 publications with PLAP and Pregnancy Complications
 Nervous System Diseases Antibodies  >19 publications with PLAP and Nervous System Diseases
 Lung Diseases Antibodies  >12 publications with PLAP and Lung Diseases
 Breast Neoplasms Antibodies  >6 publications with PLAP and Breast Neoplasms
 Disorders of Sex Development Antibodies  >5 publications with PLAP and Disorders of Sex Development
 Liver Diseases Antibodies  >5 publications with PLAP and Liver Diseases
 Colonic Neoplasms Antibodies  >4 publications with PLAP and Colonic Neoplasms
 Pain Antibodies  >3 publications with PLAP and Pain
 Kidney Diseases Antibodies  >3 publications with PLAP and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >85 publications with PLAP and Placenta
 Intestine Antibodies  >10 publications with PLAP and Intestine
 Heart Antibodies  >8 publications with PLAP and Heart
 Uterus Antibodies  >7 publications with PLAP and Uterus
 Amniotic Fluid Antibodies  >1 publications with PLAP and Amniotic Fluid
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