P14272.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
29.8 kDa
NCBI Official Full Name
Plasma kallikrein
NCBI Official Synonym Full Names
kallikrein B, plasma 1
NCBI Protein Information
plasma kallikrein
UniProt Protein Name
Plasma kallikrein
UniProt Synonym Protein Names
Fletcher factor; Kininogenin; Plasma prekallikrein
UniProt Synonym Gene Names
UniProt Entry Name
KLKB1_RAT
NCBI Summary for Klkb1
serine protease that plays a role in blood coagulation [RGD, Feb 2006]
UniProt Comments for Klkb1
KLKB1: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency); also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. Belongs to the peptidase S1 family. Plasma kallikrein subfamily.
Protein type: Secreted, signal peptide; EC 3.4.21.34; Protease; Secreted
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase activity
Biological Process: blood coagulation; fibrinolysis; inflammatory response; plasminogen activation; positive regulation of fibrinolysis; proteolysis
Product References and Citations for Klkb1 recombinant protein
Gene structure and chromosomal localization of plasma kallikrein.Beaubien G., Rosinski-Chupin I., Mattei M.-G., Mbikay M., Chretien M., Seidah N.G.Biochemistry 30:1628-1635(1991)
The cDNA structure of rat plasma kallikrein.Seidah N.G., Ladenheim R., Mbikay M., Hamelin J., Lutfalla G., Rougeon F., Lazure C., Chretien M.DNA 8:563-574(1989)
Research Articles on Klkb1
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Products associated with Klkb1 recombinant protein
Pathways associated with Klkb1 recombinant protein
Organs/Tissues associated with Klkb1 recombinant protein
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