NP_001001396.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
136,584 Da
NCBI Official Full Name
plasma membrane calcium-transporting ATPase 4 isoform 4a
NCBI Official Synonym Full Names
ATPase plasma membrane Ca2+ transporting 4
NCBI Official Synonym Symbols
MXRA1; PMCA4; ATP2B2; PMCA4b; PMCA4x [Similar Products]
NCBI Protein Information
plasma membrane calcium-transporting ATPase 4
UniProt Protein Name
Plasma membrane calcium-transporting ATPase 4
UniProt Synonym Protein Names
Matrix-remodeling-associated protein 1; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4
UniProt Synonym Gene Names
NCBI Summary for ATP2B4
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP2B4
Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility ().
Research Articles on ATP2B4
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Pathways associated with ATP2B4 recombinant protein
Diseases associated with ATP2B4 recombinant protein
Organs/Tissues associated with ATP2B4 recombinant protein
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