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SERPINE1 recombinant protein :: Plasminogen Activator Inhibitor-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143203 SERPINE1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,940 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Plasminogen Activator Inhibitor-1 (SERPINE1), Recombinant Protein

 Also Known As   

Recombinant Human Plasminogen Activator Inhibitor-1

 Product Synonym Names    SERPINE1 Human; Plasminogen Activator Inhibitor-1 Human Recombinant; PAI-1; PAI1; PLANH1; SERPINE1; PAIE; PLASMINOGEN ACTIVATOR INHIBITOR; BETA-MIGRATING ENDOTHELIAL-CELL-DERIVED TYPE
 Product Gene Name   

SERPINE1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MVHHPPSYVA HLASDFGVRV FQQVAQASKD RNVVFSPYGV ASVLAMLQLT TGGETQQQIQ AAMGFKIDDK GMAPALRHLY KELMGPWNKD EISTTDAIFV QRDLKLVQGF MPHFFRLFRS TVKQVDFSEV ERARFIINDW VKTHTKGMIS NLLGKGAVDQ LTRLVLVNAL YFNGQWKTPF PDSSTHRRLF HKSDGSTVSV PMMAQTNKFN YTEFTTPDGH YYDILELPYH GDTLSMFIAA PYEKEVPLSA LTNILSAQLI SHWKGNMTRL PRLLVLPKFS LETEVDLRKP LENLGMTDMF RQFQADFTSL SDQEPLHVAQ ALQKVKIEVN ESGTVASSST AVIVSARMAP EEIIMDRPFL FVVRHNPTGT VLFMGQVMEP
 OMIM    173360
 3D Structure    ModBase 3D Structure for P05121
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    150mM Na2HPO4, pH 6.6, 0.5mM NaCl, 2mM Glutathione and 0.01% Tween-80.
Sterile Filtered clear colorless solution.
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 Other Notes    Small volumes of SERPINE1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for SERPINE1 recombinant protein

   Description: SERPINE1 Human Recombinant fused to N-terminal His-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 400 amino acids (24-402) and having a molecular mass of 45 kDa.The SERPINE1 is purified by proprietary chromatographic techniques.

Introduction: Plasminogen activator inhibitor-1 is the principal inhibitor of tissue plasminogen activator(tPA) and urokinase(uPA), the activators of plasminogenand hence fibrinolysis(the physiological breakdown of blood clots). It is a serine protease inhibitor(serpin) protein (SERPINE1). The other PAI, plasminogen activator inhibitor-2(PAI-2) is secreted by the placentaand only present in significant amounts during pregnancy. In addition, protease nexinacts as an inhibitor of tPA and urokinase. SERPINE1, however, is the main inhibitor of the plasminogen activators.
 Product Categories/Family for SERPINE1 recombinant protein    ENZYMES; Recombinant Proteins; Serpin
NCBI/Uniprot data below describe general gene information for SERPINE1. It may not necessarily be applicable to this product.
 NCBI GI #    10835159
 NCBI GeneID    5054
 NCBI Accession #    NP_000593.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000602.4 [Other Products]
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 UniProt Primary Accession #    P05121 [Other Products]
 UniProt Secondary Accession #    B7Z4S0; F8WD53 [Other Products]
 UniProt Related Accession #    P05121 [Other Products]
 Molecular Weight    43,404 Da
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 NCBI Official Full Name    plasminogen activator inhibitor 1
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
 NCBI Official Symbol    SERPINE1 [Similar Products]
 NCBI Official Synonym Symbols   
PAI; PAI1; PAI-1; PLANH1
[Similar Products]
 NCBI Protein Information    plasminogen activator inhibitor 1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin E1
 UniProt Protein Name    Plasminogen activator inhibitor 1
 UniProt Synonym Protein Names   
Endothelial plasminogen activator inhibitor; Serpin E1
 Protein Family    Plasminogen activator inhibitor
 UniProt Gene Name    SERPINE1 [Similar Products]
 UniProt Synonym Gene Names    PAI1; PLANH1; PAI; PAI-1 [Similar Products]
 UniProt Entry Name    PAI1_HUMAN
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 NCBI Summary for SERPINE1    This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
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 UniProt Comments for SERPINE1    SERPINE1: a secreted protein that acts as 'bait' for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Belongs to the serpin family. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Plasma levels of PAI-1 and VCAM-1 together may be useful in predicting post-operative recurrence in patients with colorectal cancer.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: extracellular matrix; extracellular space; plasma membrane; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protease binding; receptor binding

Biological Process: circadian rhythm; extracellular matrix organization and biogenesis; positive regulation of blood coagulation; negative regulation of smooth muscle cell migration; defense response to Gram-negative bacterium; positive regulation of receptor-mediated endocytosis; positive regulation of interleukin-8 production; platelet degranulation; negative regulation of fibrinolysis; transforming growth factor beta receptor signaling pathway; regulation of receptor activity; angiogenesis; chronological cell aging; negative regulation of cell adhesion mediated by integrin; negative regulation of cell migration; platelet activation; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; negative regulation of blood coagulation; regulation of cell proliferation; fibrinolysis; positive regulation of angiogenesis; gene expression; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; positive regulation of inflammatory response

Disease: Plasminogen Activator Inhibitor-1 Deficiency
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 Research Articles on SERPINE1    1. The carriers of polymorphism 4G are at greater risk for early pregnancy loss than those with 5G, which confirms that carriage of the polymorphism 4G/5G 675 gene PAI-1 has a specific in pathogenesis and expression of Polycystic Ovary Syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SERPINE1 recombinant proteinPathways associated with SERPINE1 recombinant protein
 Reference Product  PubMed Publications
 TGFB1 recombinant protein  >531 publications with SERPINE1 and TGFB1
 SMAD4 recombinant protein  >82 publications with SERPINE1 and SMAD4
 HIF1A recombinant protein  >66 publications with SERPINE1 and HIF1A
 EGF recombinant protein  >63 publications with SERPINE1 and EGF
 PLG recombinant protein  >43 publications with SERPINE1 and PLG
 PLAT recombinant protein  >24 publications with SERPINE1 and PLAT
 PLAU recombinant protein  >13 publications with SERPINE1 and PLAU
 VTN recombinant protein  >5 publications with SERPINE1 and VTN
 ALB recombinant protein  >3 publications with SERPINE1 and ALB
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
Diseases associated with SERPINE1 recombinant proteinOrgans/Tissues associated with SERPINE1 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >3215 publications with SERPINE1 and Cardiovascular Diseases
 Thrombosis Antibodies  >1406 publications with SERPINE1 and Thrombosis
 Inflammation Antibodies  >1336 publications with SERPINE1 and Inflammation
 Heart Diseases Antibodies  >1055 publications with SERPINE1 and Heart Diseases
 Necrosis Antibodies  >897 publications with SERPINE1 and Necrosis
 Obesity Antibodies  >885 publications with SERPINE1 and Obesity
 Atherosclerosis Antibodies  >781 publications with SERPINE1 and Atherosclerosis
 Hypertension Antibodies  >703 publications with SERPINE1 and Hypertension
 Fibrosis Antibodies  >696 publications with SERPINE1 and Fibrosis
 Disease Models, Animal Antibodies  >542 publications with SERPINE1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5359 publications with SERPINE1 and Blood
 Vascular Antibodies  >2843 publications with SERPINE1 and Vascular
 Heart Antibodies  >941 publications with SERPINE1 and Heart
 Kidney Antibodies  >813 publications with SERPINE1 and Kidney
 Muscle Antibodies  >741 publications with SERPINE1 and Muscle
 Liver Antibodies  >622 publications with SERPINE1 and Liver
 Connective Tissue Antibodies  >590 publications with SERPINE1 and Connective Tissue
 Lung Antibodies  >585 publications with SERPINE1 and Lung
 Adipose Tissue Antibodies  >525 publications with SERPINE1 and Adipose Tissue
 Brain Antibodies  >401 publications with SERPINE1 and Brain
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