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PDGF AA recombinant protein :: Platelet Derived Growth Factor-AA Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142218 PDGF AA recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,625 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Platelet Derived Growth Factor-AA (PDGF AA), Recombinant Protein

 Also Known As   

Recombinant Human Platelet Derived Growth Factor-AA

 Product Synonym Names    PDGF AA Human; Platelet-Derived Growth Factor AA Human Recombinant; Glioma-derived growth factor; GDGF; Osteosarcoma-derived Growth Factor; ODGF; PDGF-AA; PDGF-1
 Product Gene Name   

PDGF AA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    SIEEAVPAVC KTRTVIYEIP RSQVDPTSAN FLIWPPCVEV KRCTGCCNTS SVKCQPSRVH HRSVKVAKVE YVRKKPKLKE VQVRLEEHLE CACATTSLNP DYREEDTGRP RESGKKRKRK RLKPT
 OMIM    173430
 3D Structure    ModBase 3D Structure for P04085
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    Lyophilized without any additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Platelet-derived Growth Factor-AA in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The ED50, calculated by the dose-dependent proliferation of murine 3T3 indicator cells is < 0.32ng/ml, corresponding to a Specific Activity of 3,125x103units/mg.
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 Preparation and Storage    Lyophilized Platelet-Derived Growth Factor AA although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution PDGF-AA should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of PDGF AA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PDGF AA recombinant protein

   Description: Platelet-Derived Growth Factor AA Human Recombinant is a homodimeric, non-glycosylated, polypeptide chain containing 2 x 125 amino acids and having a total molecular mass of 28511 Dalton. PDGF-AA is purified by proprietary chromatographic techniques.

Introduction: PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGF is stored in platelet alpha-granules and released upon platelet activation. The PDGF is involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGF have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB.
 Product Categories/Family for PDGF AA recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; PDGF
NCBI/Uniprot data below describe general gene information for PDGF AA. It may not necessarily be applicable to this product.
 NCBI GI #    77695917
 NCBI GeneID    5154
 NCBI Accession #    NP_002598.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_002607.5 [Other Products]
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 UniProt Primary Accession #    P04085 [Other Products]
 UniProt Secondary Accession #    B5BU73 [Other Products]
 UniProt Related Accession #    P04085 [Other Products]
 Molecular Weight    22,253 Da
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 NCBI Official Full Name    platelet-derived growth factor subunit A isoform 1 preproprotein
 NCBI Official Synonym Full Names    platelet-derived growth factor alpha polypeptide
 NCBI Official Symbol    PDGFA [Similar Products]
 NCBI Official Synonym Symbols   
PDGF1; PDGF-A
[Similar Products]
 NCBI Protein Information    platelet-derived growth factor subunit A; PDGF A-chain; PDGF subunit A; PDGF-1; platelet-derived growth factor A chain; platelet-derived growth factor alpha chain; platelet-derived growth factor alpha isoform 2 preproprotein
 UniProt Protein Name    Platelet-derived growth factor subunit A
 UniProt Synonym Protein Names   
PDGF-1; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide
 UniProt Gene Name    PDGFA [Similar Products]
 UniProt Synonym Gene Names    PDGF1; PDGF subunit A [Similar Products]
 UniProt Entry Name    PDGFA_HUMAN
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 NCBI Summary for PDGF AA    The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PDGF AA    PDGFA: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Cell cycle regulation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: Golgi membrane; extracellular space; cell surface; microvillus; endoplasmic reticulum lumen; extracellular region

Molecular Function: collagen binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding

Biological Process: skin development; extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; wound healing; negative chemotaxis; platelet-derived growth factor receptor signaling pathway; cell projection biogenesis; response to estradiol stimulus; positive regulation of MAP kinase activity; positive regulation of fibroblast proliferation; platelet degranulation; regulation of smooth muscle cell migration; hair follicle development; cell-cell signaling; positive regulation of MAPKKK cascade; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to wounding; angiogenesis; regulation of peptidyl-tyrosine phosphorylation; inner ear development; response to drug; epidermal growth factor receptor signaling pathway; platelet activation; fibroblast growth factor receptor signaling pathway; response to retinoic acid; response to inorganic substance; phosphoinositide-mediated signaling; negative regulation of phosphatidylinositol biosynthetic process; positive regulation of protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase cascade; cell activation; positive regulation of protein kinase B signaling cascade; organ morphogenesis; regulation of actin cytoskeleton organization and biogenesis; positive regulation of cell division; response to hypoxia; innate immune response; blood coagulation; actin cytoskeleton organization and biogenesis; alveolus development; positive regulation of DNA replication; positive regulation of cell migration
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 Research Articles on PDGF AA    1. PDGFA is a SOX11 direct target gene upregulated in MCL cells whose inhibition impaired SOX11-enhanced in vitro angiogenic effects on endothelial cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PDGF AA recombinant proteinPathways associated with PDGF AA recombinant protein
 Reference Product  PubMed Publications
 PDGFRA recombinant protein  >44 publications with PDGF AA and PDGFRA
 PDGFB recombinant protein  >30 publications with PDGF AA and PDGFB
 PDGFRB recombinant protein  >22 publications with PDGF AA and PDGFRB
 EGFR recombinant protein  >10 publications with PDGF AA and EGFR
 FLT1 recombinant protein  >2 publications with PDGF AA and FLT1
 FGF1 recombinant protein  >2 publications with PDGF AA and FGF1
 SP1 recombinant protein  >1 publications with PDGF AA and SP1
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Diseases associated with PDGF AA recombinant proteinOrgans/Tissues associated with PDGF AA recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >23 publications with PDGF AA and Carcinoma
 Adenocarcinoma Antibodies  >15 publications with PDGF AA and Adenocarcinoma
 Inflammation Antibodies  >11 publications with PDGF AA and Inflammation
 Fibrosis Antibodies  >9 publications with PDGF AA and Fibrosis
 Disease Models, Animal Antibodies  >8 publications with PDGF AA and Disease Models, Animal
 Brain Diseases Antibodies  >7 publications with PDGF AA and Brain Diseases
 Cell Transformation, Neoplastic Antibodies  >7 publications with PDGF AA and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >7 publications with PDGF AA and Neoplasms, Experimental
 Mesothelioma Antibodies  >4 publications with PDGF AA and Mesothelioma
 Pancreatic Neoplasms Antibodies  >4 publications with PDGF AA and Pancreatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >13 publications with PDGF AA and Liver
 Brain Antibodies  >10 publications with PDGF AA and Brain
 Lung Antibodies  >10 publications with PDGF AA and Lung
 Embryonic Tissue Antibodies  >9 publications with PDGF AA and Embryonic Tissue
 Connective Tissue Antibodies  >7 publications with PDGF AA and Connective Tissue
 Kidney Antibodies  >6 publications with PDGF AA and Kidney
 Testis Antibodies  >5 publications with PDGF AA and Testis
 Mouth Antibodies  >5 publications with PDGF AA and Mouth
 Ovary Antibodies  >5 publications with PDGF AA and Ovary
 Intestine Antibodies  >4 publications with PDGF AA and Intestine
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