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PDGF BB recombinant protein :: Platelet Derived Growth Factor-BB Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142119 PDGF BB recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,435 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Platelet Derived Growth Factor-BB (PDGF BB), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Platelet Derived Growth Factor-BB, Yeast

 Product Synonym Names    PDGF BB Human, Yeast; Platelet Derived Growth Factor-BB Human Recombinant, Yeast; Glioma-derived growth factor; GDGF; Osteosarcoma-derived Growth Factor; ODGF; SIS; SSV; PDGF2; c-sis; FLJ12858; PDGF-BB; PDGF B-chain; Platelet-derived growth factor beta polypeptide; Becaplermin; PDGF BB Yeast
 Product Gene Name   

PDGF BB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Leu-Gl y-Ser-Leu
 OMIM    190040
 3D Structure    ModBase 3D Structure for P01127
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 Host    Saccharomyces cerevisiae
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 Purity/Purification    Greater than 98.0% as determined by SDS-PAGE.
 Form/Format    The PDGF-BB was lyophilized from 0.2 um filtered solution in 20mM sodium phosphate in absence of any carrier protein.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Platelet-derived Growth Factor-BB in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    The ED50, as measured by its ability to stimulate proliferation of mouse 3T3 fibroblasts is typically 1 ng/ml, corresponding to a Specific Activity of 1,000,000IU/mg.
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 Preparation and Storage    Lyophilized Platelet-derived Growth Factor BB although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution PDGF BB should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of PDGF BB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PDGF BB recombinant protein

   Description: Platelet-Derived Growth Factor BB Human Recombinant is a glycosylated homodimer produced in Saccharomyces cerevisiae, containing 2x109 amino acids and having a molecular mass of 32kDa. PDGF-BB is purified by proprietary chromatographic techniques.

Introduction: PDGF-BB is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two splice variants have been identified for this gene.
 Product Categories/Family for PDGF BB recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; PDGF
NCBI/Uniprot data below describe general gene information for PDGF BB. It may not necessarily be applicable to this product.
 NCBI GI #    4505681
 NCBI GeneID    5155
 NCBI Accession #    NP_002599.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002608.2 [Other Products]
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 UniProt Primary Accession #    P01127 [Other Products]
 UniProt Secondary Accession #    P78431; Q15354; Q6FHE7; Q9UF23; G3XAG8 [Other Products]
 UniProt Related Accession #    P01127 [Other Products]
 Molecular Weight    25,502 Da
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 NCBI Official Full Name    platelet-derived growth factor subunit B isoform 1 preproprotein
 NCBI Official Synonym Full Names    platelet-derived growth factor beta polypeptide
 NCBI Official Symbol    PDGFB [Similar Products]
 NCBI Official Synonym Symbols   
SIS; SSV; IBGC5; PDGF2; c-sis; PDGF-2
[Similar Products]
 NCBI Protein Information    platelet-derived growth factor subunit B; PDGF subunit B; PDGF, B chain; becaplermin; platelet-derived growth factor 2; platelet-derived growth factor B chain; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); platelet-derived growth factor, beta polypeptide (oncogene SIS); proto-oncogene c-Sis
 UniProt Protein Name    Platelet-derived growth factor subunit B
 UniProt Synonym Protein Names   
PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis; INN: Becaplermin
 UniProt Gene Name    PDGFB [Similar Products]
 UniProt Synonym Gene Names    PDGF2; SIS; PDGF subunit B [Similar Products]
 UniProt Entry Name    PDGFB_HUMAN
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 NCBI Summary for PDGF BB    The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]
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 UniProt Comments for PDGF BB    PDGFB: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB. Belongs to the PDGF/VEGF growth factor family.

Protein type: Secreted, signal peptide; Oncoprotein; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: Golgi membrane; extracellular space; cell surface; basolateral plasma membrane; endoplasmic reticulum lumen; cytoplasm; extracellular region

Molecular Function: collagen binding; identical protein binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; superoxide-generating NADPH oxidase activator activity; chemoattractant activity

Biological Process: extracellular matrix organization and biogenesis; positive regulation of cyclin-dependent protein kinase activity; nerve growth factor receptor signaling pathway; heart development; positive regulation of transcription, DNA-dependent; positive regulation of fibroblast growth factor receptor signaling pathway; cell projection biogenesis; protein amino acid phosphorylation; monocyte chemotaxis; positive regulation of MAP kinase activity; positive regulation of fibroblast proliferation; positive chemotaxis; transforming growth factor beta receptor signaling pathway; cell growth; positive regulation of mitotic cell cycle, embryonic; response to drug; substrate-bound cell migration; platelet activation; fibroblast growth factor receptor signaling pathway; positive regulation of mitosis; positive regulation of chemotaxis; activation of protein kinase B; positive regulation of blood vessel endothelial cell migration; positive regulation of protein amino acid autophosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of peptidyl-tyrosine phosphorylation; activation of protein kinase activity; blood vessel morphogenesis; positive regulation of endothelial cell proliferation; actin cytoskeleton organization and biogenesis; negative regulation of transcription, DNA-dependent; embryonic placenta development; peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell proliferation; platelet-derived growth factor receptor signaling pathway; positive regulation of smooth muscle cell migration; response to estradiol stimulus; response to insulin stimulus; platelet degranulation; positive regulation of MAPKKK cascade; positive regulation of glomerular filtration; positive regulation of cell proliferation; response to wounding; hemopoiesis; DNA replication; negative regulation of cell migration; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; negative regulation of phosphatidylinositol biosynthetic process; positive regulation of phosphoinositide 3-kinase activity; peptidyl-serine phosphorylation; response to hypoxia; innate immune response; blood coagulation; positive regulation of DNA replication; positive regulation of cell migration

Disease: Meningioma, Familial, Susceptibility To; Dermatofibrosarcoma Protuberans; Basal Ganglia Calcification, Idiopathic, 5; Basal Ganglia Calcification, Idiopathic, 1
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 Research Articles on PDGF BB    1. Data show that the CXC chemokine receptor 4 (CXCR4) antagonist AMD 3100 disrupted the stromal cell-derived factor 1 (SDF-1alpha)/CXCR4 axis and decreases platelet-derived growth factor B (PDGF-B) protein expression in vivo in two xenograft Ewing tumor models.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PDGF BB recombinant proteinPathways associated with PDGF BB recombinant protein
 Reference Product  PubMed Publications
 PDGFRB recombinant protein  >694 publications with PDGF BB and PDGFRB
 PDGFRA recombinant protein  >365 publications with PDGF BB and PDGFRA
 SRC recombinant protein  >155 publications with PDGF BB and SRC
 STAT3 recombinant protein  >47 publications with PDGF BB and STAT3
 STAT1 recombinant protein  >30 publications with PDGF BB and STAT1
 PDGFA recombinant protein  >30 publications with PDGF BB and PDGFA
 AKT1 recombinant protein  >27 publications with PDGF BB and AKT1
 THBS1 recombinant protein  >15 publications with PDGF BB and THBS1
 GRB2 recombinant protein  >10 publications with PDGF BB and GRB2
 HRAS recombinant protein  >9 publications with PDGF BB and HRAS
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 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with PDGF BB recombinant proteinOrgans/Tissues associated with PDGF BB recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >270 publications with PDGF BB and Disease Models, Animal
 Fibrosis Antibodies  >244 publications with PDGF BB and Fibrosis
 Atherosclerosis Antibodies  >194 publications with PDGF BB and Atherosclerosis
 Inflammation Antibodies  >151 publications with PDGF BB and Inflammation
 Lung Diseases Antibodies  >131 publications with PDGF BB and Lung Diseases
 Necrosis Antibodies  >130 publications with PDGF BB and Necrosis
 Hyperplasia Antibodies  >116 publications with PDGF BB and Hyperplasia
 Liver Diseases Antibodies  >103 publications with PDGF BB and Liver Diseases
 Kidney Diseases Antibodies  >101 publications with PDGF BB and Kidney Diseases
 Hypertension Antibodies  >98 publications with PDGF BB and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >1236 publications with PDGF BB and Vascular
 Blood Antibodies  >686 publications with PDGF BB and Blood
 Kidney Antibodies  >223 publications with PDGF BB and Kidney
 Brain Antibodies  >221 publications with PDGF BB and Brain
 Embryonic Tissue Antibodies  >210 publications with PDGF BB and Embryonic Tissue
 Lung Antibodies  >203 publications with PDGF BB and Lung
 Liver Antibodies  >174 publications with PDGF BB and Liver
 Heart Antibodies  >143 publications with PDGF BB and Heart
 Mouth Antibodies  >102 publications with PDGF BB and Mouth
 Pancreas Antibodies  >34 publications with PDGF BB and Pancreas
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