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PPBP recombinant protein :: Platelet basic protein (PPBP) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS969188
SDS-PAGE
Unit / Price
0.002 mg  /  $115 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.25 mg  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Platelet basic protein (PPBP), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Platelet basic protein (PPBP) (Active)

 Product Synonym Names    PBP; Leukocyte-derived growth factor; LDGF; Macrophage-derived growth factor; MDGF
 Product Gene Name   

PPBP recombinant protein

[Similar Products]
 Product Synonym Gene Name    CTAP3; CXCL7; SCYB7; TGB1; THBGB1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    59-128aa, Partial
 Sequence    AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESAD
 OMIM    M54995 mRNA
 3D Structure    ModBase 3D Structure for P02775
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 Host    E Coli
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 Purity/Purification    >=97% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Biological Activity    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 1.0-10.0 ng/ml.
 Storage Buffer    0.2 um filtered PBS, pH 7.4,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PPBP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PPBP recombinant protein

   LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. {ECO:0000269|PubMed:10877842, ECO:0000269|PubMed:7890771, ECO:0000269|PubMed:8950790, ECO:0000269|PubMed:9794434}.
 Product Categories/Family for PPBP recombinant protein    Biological Active Protein; Immunology; Chemokine
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 SDS-PAGE of PPBP recombinant protein    PPBP recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PPBP. It may not necessarily be applicable to this product.
 NCBI GI #    4505981
 NCBI GeneID    5473
 NCBI Accession #    NP_002695.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002704.3 [Other Products]
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 UniProt Primary Accession #    P02775 [Other Products]
 UniProt Secondary Accession #    Q6IBJ8; B2R5F3 [Other Products]
 UniProt Related Accession #    P02775; AAB46877 [Other Products]
 Molecular Weight    7.6 kDa
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 NCBI Official Full Name    platelet basic protein preproprotein
 NCBI Official Synonym Full Names    pro-platelet basic protein
 NCBI Official Symbol    PPBP [Similar Products]
 NCBI Official Synonym Symbols   
PBP; TC1; TC2; TGB; LDGF; MDGF; TGB1; B-TG1; CTAP3; CXCL7; NAP-2; SCYB7; THBGB; LA-PF4; THBGB1; Beta-TG; CTAPIII; CTAP-III
[Similar Products]
 NCBI Protein Information    platelet basic protein
 UniProt Protein Name    Platelet basic protein
 UniProt Synonym Protein Names   
C-X-C motif chemokine 7; Leukocyte-derived growth factor; LDGF
 Protein Family    Platelet basic protein
 UniProt Gene Name    PPBP [Similar Products]
 UniProt Synonym Gene Names    CTAP3; CXCL7; SCYB7; TGB1; THBGB1; PBP; LDGF; MDGF; CTAP-III; CTAP-III(1-81); Beta-TG; NAP-2(74); NAP-2(73); NAP-2; NAP-2(1-66); NAP-2(1-63) [Similar Products]
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 NCBI Summary for PPBP    The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]
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 UniProt Comments for PPBP    LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.
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 Research Articles on PPBP    1. Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PPBP recombinant proteinPathways associated with PPBP recombinant protein
 Reference Product  PubMed Publications
 CXCR2 recombinant protein  >12 publications with PPBP and CXCR2
 CCL5 recombinant protein  >7 publications with PPBP and CCL5
 CXCR1 recombinant protein  >6 publications with PPBP and CXCR1
 ALB recombinant protein  >1 publications with PPBP and ALB
 CXCL12 recombinant protein  >1 publications with PPBP and CXCL12
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with PPBP recombinant proteinOrgans/Tissues associated with PPBP recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >41 publications with PPBP and Inflammation
 Cardiovascular Diseases Antibodies  >27 publications with PPBP and Cardiovascular Diseases
 Heart Diseases Antibodies  >12 publications with PPBP and Heart Diseases
 Lung Diseases Antibodies  >9 publications with PPBP and Lung Diseases
 Atherosclerosis Antibodies  >7 publications with PPBP and Atherosclerosis
 Necrosis Antibodies  >6 publications with PPBP and Necrosis
 Carcinoma Antibodies  >3 publications with PPBP and Carcinoma
 Edema Antibodies  >3 publications with PPBP and Edema
 Hypersensitivity Antibodies  >3 publications with PPBP and Hypersensitivity
 Breast Neoplasms Antibodies  >2 publications with PPBP and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >121 publications with PPBP and Blood
 Connective Tissue Antibodies  >77 publications with PPBP and Connective Tissue
 Lung Antibodies  >9 publications with PPBP and Lung
 Heart Antibodies  >5 publications with PPBP and Heart
 Bone Marrow Antibodies  >5 publications with PPBP and Bone Marrow
 Prostate Antibodies  >3 publications with PPBP and Prostate
 Intestine Antibodies  >3 publications with PPBP and Intestine
 Liver Antibodies  >3 publications with PPBP and Liver
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