NP_001081143.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
72,846 Da
NCBI Official Full Name
poly(A)-specific ribonuclease PARN
NCBI Official Synonym Full Names
poly(A)-specific ribonuclease L homeolog
NCBI Protein Information
poly(A)-specific ribonuclease PARN
UniProt Protein Name
Poly(A)-specific ribonuclease PARN
UniProt Synonym Protein Names
Deadenylating nuclease; Deadenylation nuclease; Polyadenylate-specific ribonuclease; parn-A
UniProt Comments for parn
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. Required during meiotic maturation to silence certain maternal mRNAs translationally. Does not require an adenosine residue at the 3' end, however, the addition of 25 non-adenylate residues at the 3' terminus, or a 3' terminal phosphate is inhibitory. Involved in dormant mRNAs regulation during oocyte maturation by counteracting polyadenylation mediated by papd4/gld2nt in immature eggs. During maturation it is excluded from the ribonucleoprotein complex, allowing poly(A) elongation by papd4/gld2nt and activation of mRNAs.
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Pathways associated with parn recombinant protein
Diseases associated with parn recombinant protein
Organs/Tissues associated with parn recombinant protein
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