NP_034725.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
56,409 Da
NCBI Official Full Name
potassium voltage-gated channel subfamily A member 1
NCBI Official Synonym Full Names
potassium voltage-gated channel, shaker-related subfamily, member 1
NCBI Official Synonym Symbols
MBK1; Mk-1; Shak; Kv1.1; mceph; Kca1-1; AI840627 [Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily A member 1
UniProt Protein Name
Potassium voltage-gated channel subfamily A member 1
UniProt Synonym Protein Names
MBK1
UniProt Entry Name
KCNA1_MOUSE
UniProt Comments for Kcna1
Kv1.1: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1); also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent. Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1). Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium
Cellular Component: apical plasma membrane; axon; cell junction; cell projection; cell soma; cell surface; cytoplasmic vesicle; cytosol; dendrite; endoplasmic reticulum; integral to membrane; integral to plasma membrane; membrane; nerve terminal; paranode region of axon; plasma membrane; presynaptic membrane; synapse; voltage-gated potassium channel complex
Molecular Function: delayed rectifier potassium channel activity; ion channel activity; potassium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity
Biological Process: brain development; detection of mechanical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of touch; generation of action potential; hippocampus development; ion transport; neuroblast proliferation; neuromuscular process; potassium ion transport; protein homooligomerization; regulation of membrane potential; regulation of muscle contraction; startle response; transmembrane transport; transport
Research Articles on Kcna1
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Products associated with Kcna1 recombinant protein
Pathways associated with Kcna1 recombinant protein
Diseases associated with Kcna1 recombinant protein
Organs/Tissues associated with Kcna1 recombinant protein
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