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KCNA1 recombinant protein :: Potassium voltage-gated channel subfamily A member 1 protein Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1265383
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $710 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $860 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $960 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,075 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,085 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,100 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,570 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,635 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,680 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,105 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Potassium voltage-gated channel subfamily A member 1 protein (KCNA1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant human Potassium voltage-gated channel subfamily A member 1 protein

 Product Gene Name   

KCNA1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-154aa; Partial
 Sequence    MTVMSGENVD EASAAPGHPQ DGSYPRQADH DDHECCERVV INISGLRFET QLKTLAQFPN TLLGNPKKRM RYFDPLRNEY FFDRNRPSFD AILYYYQSGG RLRRPVNVPL DMFSEEIKFY ELGEEAMEKF REDEGFIKEE ERPLPEKEYQ RQVW
 Chromosome Location    Chromosome: 12; NC_000012.11 (5019073..5027422). Location: 12p13.32
 OMIM    160120
 3D Structure    ModBase 3D Structure for Q09470
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90%(SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of KCNA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for KCNA1 recombinant protein

   Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
 Product Categories/Family for KCNA1 recombinant protein    Neuroscience
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 SDS-PAGE of KCNA1 recombinant protein    KCNA1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for KCNA1. It may not necessarily be applicable to this product.
 NCBI GI #    119395748
 NCBI GeneID    3736
 NCBI Accession #    NP_000208.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000217.2 [Other Products]
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 UniProt Primary Accession #    Q09470 [Other Products]
 UniProt Secondary Accession #    Q3MIQ9; A6NM83 [Other Products]
 UniProt Related Accession #    Q09470 [Other Products]
 Molecular Weight    22kD [Similar Products]
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 NCBI Official Full Name    potassium voltage-gated channel subfamily A member 1
 NCBI Official Synonym Full Names    potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
 NCBI Official Symbol    KCNA1 [Similar Products]
 NCBI Official Synonym Symbols   
EA1; MK1; AEMK; HBK1; HUK1; MBK1; RBK1; KV1.1
[Similar Products]
 NCBI Protein Information    potassium voltage-gated channel subfamily A member 1; voltage-gated K(+) channel HuKI; voltage-gated potassium channel HBK1; voltage-gated potassium channel subunit Kv1.1
 UniProt Protein Name    Potassium voltage-gated channel subfamily A member 1
 UniProt Synonym Protein Names   
Voltage-gated K(+) channel HuKI; Voltage-gated potassium channel HBK1; Voltage-gated potassium channel subunit Kv1.1
 Protein Family    Potassium voltage-gated channel subfamily
 UniProt Gene Name    KCNA1 [Similar Products]
 UniProt Entry Name    KCNA1_HUMAN
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 NCBI Summary for KCNA1    This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008]
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 UniProt Comments for KCNA1    Kv1.1: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1); also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent. Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1). Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 12p13.32

Cellular Component: voltage-gated potassium channel complex; cell surface; endoplasmic reticulum; integral to plasma membrane; paranode region of axon; cytoplasmic membrane-bound vesicle; dendrite; integral to membrane; perikaryon; cytosol; presynaptic membrane; cell soma; apical plasma membrane; plasma membrane; synapse; nerve terminal; cell junction

Molecular Function: protein binding; voltage-gated potassium channel activity; potassium channel activity; delayed rectifier potassium channel activity; potassium ion transmembrane transporter activity

Biological Process: detection of mechanical stimulus involved in sensory perception of pain; synaptic transmission; regulation of membrane potential; regulation of muscle contraction; neuromuscular process; generation of action potential; protein homooligomerization; potassium ion transport; detection of mechanical stimulus involved in sensory perception of touch

Disease: Episodic Ataxia, Type 1
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 Research Articles on KCNA1    1. characterization of mutations in the potassium channel Kv1.1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KCNA1 recombinant proteinPathways associated with KCNA1 recombinant protein
 Reference Product  PubMed Publications
 KCNA2 recombinant protein  >36 publications with KCNA1 and KCNA2
 KCNA3 recombinant protein  >18 publications with KCNA1 and KCNA3
 KCNA4 recombinant protein  >18 publications with KCNA1 and KCNA4
 KCNQ2 recombinant protein  >5 publications with KCNA1 and KCNQ2
 KCNQ1 recombinant protein  >2 publications with KCNA1 and KCNQ1
 KCNQ3 recombinant protein  >2 publications with KCNA1 and KCNQ3
 KCNAB2 recombinant protein  >2 publications with KCNA1 and KCNAB2
 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram
Diseases associated with KCNA1 recombinant proteinOrgans/Tissues associated with KCNA1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >103 publications with KCNA1 and Nervous System Diseases
 Dyskinesias Antibodies  >48 publications with KCNA1 and Dyskinesias
 Seizures Antibodies  >27 publications with KCNA1 and Seizures
 Cardiovascular Diseases Antibodies  >7 publications with KCNA1 and Cardiovascular Diseases
 Arrhythmias, Cardiac Antibodies  >7 publications with KCNA1 and Arrhythmias, Cardiac
 Heart Diseases Antibodies  >7 publications with KCNA1 and Heart Diseases
 Pain Antibodies  >7 publications with KCNA1 and Pain
 Drug Toxicity Antibodies  >6 publications with KCNA1 and Drug Toxicity
 Movement Disorders Antibodies  >4 publications with KCNA1 and Movement Disorders
 Tachycardia Antibodies  >3 publications with KCNA1 and Tachycardia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >94 publications with KCNA1 and Brain
 Muscle Antibodies  >39 publications with KCNA1 and Muscle
 Kidney Antibodies  >12 publications with KCNA1 and Kidney
 Ovary Antibodies  >4 publications with KCNA1 and Ovary
 Eye Antibodies  >1 publications with KCNA1 and Eye
 Lung Antibodies  >1 publications with KCNA1 and Lung
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