Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow PZP  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • GNAT3 Antibody
 • LIG3 Antibody
 • Spondin 2 (SPON2) ELISA Kit
 • C-Reactive Protein (CRP) Recombinant Protein
 • HMGCR Antibody
 • melanin ELISA Kit
 • ARL11 Antibody
 • T Lymphocyte Subpopulation Cd3-4-8 (TLS) ELISA Kit
 • Donkey anti Rabbit IgG (H + L) (Cy3) Secondary Antibody
 • ARC Antibody
 • Soluble transferrin receptor (sTfR) ELISA Kit
 • interleukin 22 (IL22) ELISA Kit
 • Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 1 (GRIN... ELISA Kit
 • KBTBD7 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

PZP recombinant protein :: Pregnancy zone Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS948491
SDS-Page
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $760 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,010 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,015 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,120 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,255 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,280 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,590 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,845 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,905 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,450 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pregnancy zone (PZP), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Pregnancy zone protein

 Product Synonym Names    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
 Product Gene Name   

PZP recombinant protein

[Similar Products]
 Product Synonym Gene Name    CPAMD6 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 MBS948491 COA    COA PDF
 Sequence Positions    472-821aa; Partial of Isoform 2
 Sequence    MKPEAELSVS SVYNLLTVKD LTNFPDNVDQ QEEEQGHCPR PFFIHNGAIY VPLSSNEADI YSFLKGMGLK VFTNSKIRKP KSCSVIPSVS AGAVGQGYYG AGLGVVERPY VPQLGTYNVI PLNNEQSSGP VPETVRSYFP ETWIWELVAV NSSGVAEVGV TVPDTITEWK AGAFCLSEDA GLGISSTASL RAFQPFFVEL TMPYSVIRGE VFTLKATVLN YLPKCIRAEG IEQEKTFSSM TCASGANVSE QLSLKLPSNV VKESARASFS VLGDILGSAM QNIQNLLQMP YGCGEQNMVL FAPNIYVLNY LNETQQLTQE IKAKAVGYLI TGYQRQLNYK HQDGSYSTFG
 OMIM    176420
 3D Structure    ModBase 3D Structure for P20742
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
Section Bar
 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PZP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for PZP recombinant protein

   Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme rains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
 Product Categories/Family for PZP recombinant protein    Neuroscience
Section Bar
 SDS-Page of PZP recombinant protein    PZP recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for PZP. It may not necessarily be applicable to this product.
 NCBI GI #    281185515
 NCBI Accession #    P20742.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P20742 [Other Products]
 UniProt Secondary Accession #    Q15273; Q2NKL2; Q7M4N7; A6ND27 [Other Products]
 Molecular Weight    42.3kD
Table BarTOPTable Bar
 NCBI Official Full Name    Pregnancy zone protein
 UniProt Protein Name    Pregnancy zone protein
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
 Protein Family    Pregnancy zone protein
 UniProt Gene Name    PZP [Similar Products]
 UniProt Synonym Gene Names    CPAMD6 [Similar Products]
 UniProt Entry Name    PZP_HUMAN
Section Bar
 NCBI Summary for PZP    The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]
Section Bar
 UniProt Comments for PZP    PZP: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12p13-p12.2

Cellular Component: extracellular region

Molecular Function: endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity

Biological Process: female pregnancy
Table BarTOPTable Bar
 

Product References and Citations for PZP recombinant protein

   Primary structure of pregnancy zone protein. Molecular cloning of a full-length PZP cDNA clone by the polymerase chain reaction.Devriendt K., van den Berghe H., Cassiman J.-J., Marynen P.Biochim. Biophys. Acta 1088:95-103(1991) The finished DNA sequence of human chromosome 12.Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.Nature 440:346-351(2006) Alpha-macroglobulin domain structure studied by specific limited proteolysis.Thomsen N.K., Sottrup-Jensen L.Arch. Biochem. Biophys. 300:327-334(1993) A genetic polymorphism in a functional domain of human pregnancy zone protein the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin.Marynen P., Devriendt K., van den Berghe H., Cassiman J.-J.FEBS Lett. 262:349-352(1990) The alpha-macroglobulin bait region. Sequence diversity and localization of cleavage sites for proteinases in five mammalian alpha-macroglobulins.Sottrup-Jensen L., Sand O., Kristensen L., Fey G.H.J. Biol. Chem. 264:15781-15789(1989) Characterization of human pregnancy zone protein. Comparison with human alpha 2-macroglobulin.Sand O., Folkersen J., Westergaard J.G., Sottrup-Jensen L.J. Biol. Chem. 260:15723-15735(1985) A cluster of alpha 2-macroglobulin-related genes (alpha 2 M) on human chromosome 12p cloning of the pregnancy-zone protein gene and an alpha 2M pseudogene.Devriendt K., Zhang J., van Leuven F., van den Berghe H., Cassiman J.-J., Marynen P.Gene 81:325-334(1989) Pregnancy zone protein, a proteinase-binding macroglobulin. Interactions with proteinases and methylamine.Christensen U., Simonsen M., Harrit N., Sottrup-Jensen L.Biochemistry 28:9324-9331(1989) Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.J. Proteome Res. 4:2070-2080(2005) Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.J. Proteome Res. 8:651-661(2009) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) The consensus coding sequences of human breast and colorectal cancers.Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.Science 314:268-274(2006)
Section Bar
 Research Articles on PZP    1. The data of this study link the finding of elevated serum PZP levels with the characteristic Alzheimer's Disease pathology and identify PZP as a novel component in Alzheimer's Disease.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Organs/Tissues associated with PZP recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >14 publications with PZP and Liver
 Brain Antibodies  >13 publications with PZP and Brain
 Uterus Antibodies  >5 publications with PZP and Uterus
 Lung Antibodies  >2 publications with PZP and Lung
 Trachea Antibodies  >1 publications with PZP and Trachea
 Testis Antibodies  >1 publications with PZP and Testis
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions