NP_443212.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
nuclear receptor subfamily 1 group I member 2
NCBI Official Synonym Full Names
nuclear receptor subfamily 1, group I, member 2
NCBI Official Synonym Symbols
NCBI Protein Information
nuclear receptor subfamily 1 group I member 2; orphan nuclear receptor PXR; nuclear receptor subfamily 1, group 1, member 2; pregnane X receptor (nuclear receptor sub family 1, group I, member 2)
UniProt Protein Name
Nuclear receptor subfamily 1 group I member 2
UniProt Synonym Protein Names
Orphan nuclear receptor PXR; Pregnane X receptor
UniProt Synonym Gene Names
UniProt Entry Name
NR1I2_RAT
NCBI Summary for PXR
involved in the induction of cytochrome P4503A (CYP3A) [RGD, Feb 2006]
UniProt Comments for PXR
PXR: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. Heterodimer with RXR. Interacts with NCOA1. Expressed in liver, colon and small intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Nuclear receptor
Cellular Component: nucleus
Molecular Function: ligand-dependent nuclear receptor activity; zinc ion binding; steroid hormone receptor activity; drug binding
Biological Process: intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; xenobiotic metabolic process; drug export; positive regulation of transcription, DNA-dependent; exogenous drug catabolic process; steroid hormone mediated signaling; xenobiotic transport; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
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Pathways associated with PXR recombinant protein
Diseases associated with PXR recombinant protein
Organs/Tissues associated with PXR recombinant protein
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