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LMNA recombinant protein :: Prelamin-A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143643 LMNA recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $940 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Prelamin-A (LMNA), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Prelamin-A

 Product Synonym Names    Prelamin-A/C, LMNA, LMN1, FPL, IDC, LFP, CDDC, EMD2, FPLD, HGPS, LDP1, LMNC, PRO1, CDCD1, CMD1A, FPLD2, LMNL1, CMT2B1, LGMD1B.
 Product Gene Name   

LMNA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    metpsqrrat rsgaqasstp lsptritrlq ekedlqelnd rlavyidrvr sletenaglr lriteseevv srevsgikaa yeaelgdark tldsvakera rlqlelskvr eefkelkarn tkkegdliaa qarlkdleal lnskeaalst alsekrtleg elhdlrgqva kleaalgeak kqlqdemlrr vdaenrlqtm keeldfqkni yseelretkr rhetrlveid ngkqrefesr ladalqelra qhedqveqyk kelektysak ldnarqsaer nsnlvgaahe elqqsririd slsaqlsqlq kqlaakeakl rdledslare rdtsrrllae keremaemra rmqqqldeyq elldiklald meihayrkll egeeerlrls psptsqrsrg rasshssqtq gggsvtkkrk lestesrssf sqhartsgrv aveevdeegk fvrlrnksne dqsmgnwqik rqngddpllt yrfppkftlk agqvvtiwaa gagathsppt dlvwkaqntw gcgnslrtal instgeevam rklvrsvtvv eddededgdd llhhhhgshc sssgdpaeyn lrsrtvlcgt cgqpadkasa sgsgaqvggp issgssassv tvtrsyrsvg gsgggsfgdn lvtrsyllgn ssprtqspqn csim
 OMIM    115200
 3D Structure    ModBase 3D Structure for P02545
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    The Prelamin-A solution (0.1mg/ml) contains 10% Glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of LMNA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for LMNA recombinant protein

   Description: Recombinant Prelamin-A is a 74kDa precursor of the nuclear lamin A protein. Prelamin-A is a structural component of the nuclear lamina and it is encoded by lamin A/C gene (LMNA). Due to the presence of a CAAX box sequence at carboxyl terminus, Prelamin-A in vivo goes through a serial of post-translational modifications, resulting in the farnesylation of the cysteine thiol, removal of the AAX tripeptide, carboxyl-methylation of the cysteinyl carboxy group and proteolysis of 18 C-terminal amino acids residues that lead to mature lamin A. Diverse mutations in the lamin A/C gene are associated with different deseases that are collectively called laminophaties, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Recombinant human prelamin A is fused to a 6 Histidine tag at the N-terminus.
 Product Categories/Family for LMNA recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for LMNA. It may not necessarily be applicable to this product.
 NCBI GI #    383792150
 NCBI GeneID    4000
 NCBI Accession #    NP_001244303.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001257374.2 [Other Products]
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 UniProt Primary Accession #    P02545 [Other Products]
 UniProt Secondary Accession #    P02546; Q5I6Y4; Q5I6Y6; Q5TCJ2; Q5TCJ3; Q6UYC3; Q969I8; B4DI32; D3DVB0; D6RAQ3; E7EUI9 [Other Products]
 UniProt Related Accession #    P02545 [Other Products]
 Molecular Weight    69,249 Da [Similar Products]
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 NCBI Official Full Name    lamin isoform D
 NCBI Official Synonym Full Names    lamin A/C
 NCBI Official Symbol    LMNA [Similar Products]
 NCBI Official Synonym Symbols   
FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1; LGMD1B
[Similar Products]
 NCBI Protein Information    lamin; 70 kDa lamin; lamin A/C-like 1; prelamin-A/C; renal carcinoma antigen NY-REN-32
 UniProt Protein Name    Prelamin-A/C
 UniProt Synonym Protein Names   
70 kDa lamin; Renal carcinoma antigen NY-REN-32
 Protein Family    Prelamin
 UniProt Gene Name    LMNA [Similar Products]
 UniProt Synonym Gene Names    LMN1 [Similar Products]
 UniProt Entry Name    LMNA_HUMAN
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 NCBI Summary for LMNA    The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
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 UniProt Comments for LMNA    lamin A/C: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. Cleaved by caspase-6 during apoptosis into a 40-45 kDa and a28 kDa fragment.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: nucleoplasm; nuclear lamina; nuclear membrane; perinuclear region of cytoplasm; cytoplasm; lamin filament; intermediate filament; nuclear speck; nuclear envelope; cytosol; nucleus

Molecular Function: protein binding; structural molecule activity

Biological Process: mitotic nuclear envelope reassembly; muscle development; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; apoptosis; unfolded protein response; ventricular cardiac muscle cell development; mitotic nuclear envelope disassembly; sterol regulatory element binding protein nuclear translocation; mitotic cell cycle; regulation of cell migration; cell structure disassembly during apoptosis; establishment and/or maintenance of microtubule cytoskeleton polarity

Disease: Heart-hand Syndrome, Slovenian Type; Emery-dreifuss Muscular Dystrophy 2, Autosomal Dominant; Restrictive Dermopathy, Lethal; Muscular Dystrophy, Congenital, Lmna-related; Mandibuloacral Dysplasia With Type A Lipodystrophy; Charcot-marie-tooth Disease, Axonal, Type 2b1; Emery-dreifuss Muscular Dystrophy 3, Autosomal Recessive; Lipodystrophy, Familial Partial, Type 2; Hutchinson-gilford Progeria Syndrome; Cardiomyopathy, Dilated, 1a; Muscular Dystrophy, Limb-girdle, Type 1b; Cardiomyopathy, Dilated, With Hypergonadotropic Hypogonadism
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 Research Articles on LMNA    1. Loss of tissue-specific lamin A interactions may be a mechanism for the tissue-specific appearance of laminopathic phenotypes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LMNA recombinant proteinPathways associated with LMNA recombinant protein
 Reference Product  PubMed Publications
 EMD recombinant protein  >18 publications with LMNA and EMD
 LMNB1 recombinant protein  >16 publications with LMNA and LMNB1
 LMNB2 recombinant protein  >10 publications with LMNA and LMNB2
 SYNE1 recombinant protein  >5 publications with LMNA and SYNE1
 TMPO recombinant protein  >3 publications with LMNA and TMPO
 CASP6 recombinant protein  >3 publications with LMNA and CASP6
 FOS recombinant protein  >2 publications with LMNA and FOS
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Breakdown Of The Nuclear Lamina Pathway antibodies  Breakdown Of The Nuclear Lamina Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with LMNA recombinant proteinOrgans/Tissues associated with LMNA recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >272 publications with LMNA and Cardiovascular Diseases
 Progeria Antibodies  >259 publications with LMNA and Progeria
 Heart Diseases Antibodies  >239 publications with LMNA and Heart Diseases
 Cardiomyopathy, Dilated Antibodies  >198 publications with LMNA and Cardiomyopathy, Dilated
 Muscular Dystrophy, Emery-Dreifuss Antibodies  >142 publications with LMNA and Muscular Dystrophy, Emery-Dreifuss
 Lipodystrophy, Familial Partial Antibodies  >132 publications with LMNA and Lipodystrophy, Familial Partial
 Death, Sudden, Cardiac Antibodies  >51 publications with LMNA and Death, Sudden, Cardiac
 Muscular Dystrophies, Limb-Girdle Antibodies  >40 publications with LMNA and Muscular Dystrophies, Limb-Girdle
 Heart Block Antibodies  >34 publications with LMNA and Heart Block
 Werner Syndrome Antibodies  >28 publications with LMNA and Werner Syndrome
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >268 publications with LMNA and Muscle
 Heart Antibodies  >180 publications with LMNA and Heart
 Skin Antibodies  >120 publications with LMNA and Skin
 Adipose Tissue Antibodies  >89 publications with LMNA and Adipose Tissue
 Blood Antibodies  >82 publications with LMNA and Blood
 Bone Antibodies  >73 publications with LMNA and Bone
 Nerve Antibodies  >53 publications with LMNA and Nerve
 Connective Tissue Antibodies  >47 publications with LMNA and Connective Tissue
 Vascular Antibodies  >46 publications with LMNA and Vascular
 Brain Antibodies  >27 publications with LMNA and Brain
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