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Psen1 recombinant protein :: Presenilin-1 (Psen1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS967898 Psen1 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,195 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,655 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Presenilin-1 (Psen1), Recombinant Protein

 Also Known As   

Recombinant Rat Presenilin-1 (Psen1)

 Product Synonym Names    Recombinant Presenilin-1 (Psen1); Presenilin-1; PS-1 EC= 3.4.23.-; Protein S182 Cleaved into the following 3 chains: 1. Presenilin-1 NTF subunit 2. Presenilin-1 CTF subunit 3. Presenilin-1 CTF12; 4. PS1-CTF12
 Product Gene Name   

Psen1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Psen1; Psnl1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    347-468
 Sequence    SHLGPHRSTP ESRAAVQELS GSILTSEDPE ERGVKLGLGD FIFYSVLVGK ASATASGDWN TTIACFVAIL IGLCLTLLLL AIFKKALPAL PISITFGLIF YFATDYLVQP FMDQLAFHQF YI
 Chromosome Location    Chromosome: 6; NC_005105.3 (118326276..118361124, complement). Location: 6q31
 3D Structure    ModBase 3D Structure for P97887
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Psen1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Psen1. It may not necessarily be applicable to this product.
 NCBI GI #    47575859
 NCBI GeneID    29192
 NCBI Accession #    NP_062036.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_019163.3 [Other Products]
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 UniProt Primary Accession #    P97887 [Other Products]
 UniProt Secondary Accession #    P97529 [Other Products]
 UniProt Related Accession #    P97887 [Other Products]
 Molecular Weight    52,790 Da [Similar Products]
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 NCBI Official Full Name    presenilin-1
 NCBI Official Synonym Full Names    presenilin 1
 NCBI Official Symbol    Psen1 [Similar Products]
 NCBI Protein Information    presenilin-1; PS-1
 UniProt Protein Name    Presenilin-1
 UniProt Synonym Protein Names   
Protein S182
 Protein Family    Presenilin
 UniProt Gene Name    Psen1 [Similar Products]
 UniProt Synonym Gene Names    Psnl1; PS-1; PS1-CTF12 [Similar Products]
 UniProt Entry Name    PSN1_RAT
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 NCBI Summary for Psen1    multitransmembrane protein; human homolog mutated in most cases of early onset familial Alzheimer's disease; may mediate retinal lamination and pattern formation [RGD, Feb 2006]
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 UniProt Comments for Psen1    PSEN1: probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Regulates epithelial- cadherin function. Five alternative splice isoforms have been identified.

Protein type: Mitochondrial; EC 3.4.23.-; Membrane protein, multi-pass; Membrane protein, integral; Protease; Cell surface

Cellular Component: Golgi apparatus; centrosome; nuclear outer membrane; cell surface; smooth endoplasmic reticulum; mitochondrion; integral to plasma membrane; lysosomal membrane; dendrite; lipid raft; kinetochore; ciliary rootlet; membrane; cell soma; perinuclear region of cytoplasm; apical plasma membrane; mitochondrial inner membrane; cytoplasmic vesicle; dendritic shaft; intracellular; neuromuscular junction; endoplasmic reticulum membrane; nuclear membrane; neuron projection; protein complex; rough endoplasmic reticulum; endoplasmic reticulum; cell; cell cortex; Z disc; Golgi membrane; growth cone; axon; plasma membrane; nucleus

Molecular Function: peptidase activity; protein binding; cadherin binding; calcium channel activity; endopeptidase activity; beta-catenin binding; aspartic-type endopeptidase activity; PDZ domain binding

Biological Process: positive regulation of catalytic activity; activation of MAPKK activity; positive regulation of apoptosis; heart development; beta-amyloid formation; regulation of synaptic plasticity; segmentation; positive regulation of coagulation; Wnt receptor signaling pathway through beta-catenin; proteolysis; choline transport; T cell receptor signaling pathway; T cell activation during immune response; mitochondrial transport; post-embryonic development; neuron differentiation; positive regulation of MAP kinase activity; epithelial cell proliferation; cell-cell adhesion; negative regulation of axonogenesis; negative regulation of neuron apoptosis; locomotion; embryonic limb morphogenesis; autophagic vacuole formation; somitogenesis; regulation of phosphorylation; skin morphogenesis; regulation of epidermal growth factor receptor activity; Notch receptor processing; eye photoreceptor cell development; neurogenesis; negative regulation of ubiquitin-protein ligase activity; negative regulation of protein kinase activity; autophagy; neuron development; Cajal-Retzius cell differentiation; hemopoietic progenitor cell differentiation; cerebral cortex development; response to oxidative stress; negative regulation of apoptosis; regulation of synaptic transmission, glutamatergic; protein maturation; neuron migration; protein amino acid glycosylation; cell fate specification; myeloid dendritic cell differentiation; negative regulation of transcription from RNA polymerase II promoter; protein transport; amyloid precursor protein catabolic process; learning and/or memory; negative regulation of protein amino acid phosphorylation; calcium ion transport; beta-amyloid metabolic process; regulation of resting membrane potential; forebrain development; brain morphogenesis; heart looping; positive regulation of receptor recycling; dorsoventral neural tube patterning; blood vessel development; Notch signaling pathway; L-glutamate transport; thymus development; membrane protein ectodomain proteolysis; memory; negative regulation of epidermal growth factor receptor activity; cellular calcium ion homeostasis; smooth endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; neuron apoptosis; cellular protein metabolic process; cerebral cortex cell migration; skeletal morphogenesis; positive regulation of protein kinase activity; regulation of protein binding; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; myeloid leukocyte differentiation; protein processing; brain development; positive regulation of protein amino acid phosphorylation; synaptic vesicle targeting; response to DNA damage stimulus
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 Research Articles on Psen1    1. Vitamin E may depress the production of Abeta by regulating the expression of PS-1 in the hippocampus of female senile rats.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Psen1 recombinant proteinPathways associated with Psen1 recombinant protein
 Reference Product  PubMed Publications
 Aph1a recombinant protein  >35 publications with Psen1 and Aph1a
 Ncstn recombinant protein  >11 publications with Psen1 and Ncstn
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 NRIF Signals Cell Death From The Nucleus Pathway antibodies  NRIF Signals Cell Death From The Nucleus Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
Diseases associated with Psen1 recombinant proteinOrgans/Tissues associated with Psen1 recombinant protein
 Disease Name  Pubmed Publications
 Dementia Antibodies  >1361 publications with Psen1 and Dementia
 Nervous System Diseases Antibodies  >1333 publications with Psen1 and Nervous System Diseases
 Brain Diseases Antibodies  >1319 publications with Psen1 and Brain Diseases
 Alzheimer Disease Antibodies  >1319 publications with Psen1 and Alzheimer Disease
 Mental Disorders Antibodies  >1301 publications with Psen1 and Mental Disorders
 Disease Models, Animal Antibodies  >189 publications with Psen1 and Disease Models, Animal
 Neoplasms Antibodies  >72 publications with Psen1 and Neoplasms
 Neurobehavioral Manifestations Antibodies  >68 publications with Psen1 and Neurobehavioral Manifestations
 Cognition Disorders Antibodies  >47 publications with Psen1 and Cognition Disorders
 Frontotemporal Dementia Antibodies  >45 publications with Psen1 and Frontotemporal Dementia
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >718 publications with Psen1 and Brain
 Kidney Antibodies  >52 publications with Psen1 and Kidney
 Embryonic Tissue Antibodies  >24 publications with Psen1 and Embryonic Tissue
 Muscle Antibodies  >19 publications with Psen1 and Muscle
 Liver Antibodies  >13 publications with Psen1 and Liver
 Ovary Antibodies  >10 publications with Psen1 and Ovary
 Eye Antibodies  >8 publications with Psen1 and Eye
 Heart Antibodies  >8 publications with Psen1 and Heart
 Spleen Antibodies  >6 publications with Psen1 and Spleen
 Lung Antibodies  >5 publications with Psen1 and Lung
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