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Psen1 recombinant protein :: Presenilin-1 (Psen1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS967898 Psen1 recombinant protein
Unit / Price
1 mg (E-Coli)  /  $1,195 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,655 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Presenilin-1 (Psen1), Recombinant Protein

 Also Known As   

Recombinant Rat Presenilin-1 (Psen1), partial

 Product Gene Name   

Psen1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    347-468
 Sequence    SHLGPHRSTP ESRAAVQELS GSILTSEDPE ERGVKLGLGD FIFYSVLVGK ASATASGDWN TTIACFVAIL IGLCLTLLLL AIFKKALPAL PISITFGLIF YFATDYLVQP FMDQLAFHQF YI
 3D Structure    ModBase 3D Structure for P97887
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Psen1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Psen1. It may not necessarily be applicable to this product.
 NCBI GI #    47575859
 NCBI GeneID    29192
 NCBI Accession #    NP_062036.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_019163.3 [Other Products]
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 UniProt Primary Accession #    P97887 [Other Products]
 UniProt Secondary Accession #    P97529 [Other Products]
 UniProt Related Accession #    P97887 [Other Products]
 Molecular Weight    52,790 Da
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 NCBI Official Full Name    presenilin-1
 NCBI Official Synonym Full Names    presenilin 1
 NCBI Official Symbol    Psen1 [Similar Products]
 NCBI Protein Information    presenilin-1
 UniProt Protein Name    Presenilin-1
 UniProt Synonym Protein Names   
Protein S182
 Protein Family    Presenilin
 UniProt Gene Name    Psen1 [Similar Products]
 UniProt Synonym Gene Names    Psnl1; PS-1; PS1-CTF12 [Similar Products]
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 NCBI Summary for Psen1    multitransmembrane protein; human homolog mutated in most cases of early onset familial Alzheimer's disease; may mediate retinal lamination and pattern formation [RGD, Feb 2006]
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 UniProt Comments for Psen1    Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (). Required for normal embryonic brain and skeleton development, and for normal angiogenesis ().
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 Research Articles on Psen1    1. Cultured hippocampal neurons expressing mutant PS1 had attenuated CCE that was associated with destabilized dendritic spines, which were rescued by either gamma-secretase inhibition or overexpression of STIM1.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Psen1 recombinant proteinPathways associated with Psen1 recombinant protein
 Reference Product  PubMed Publications
 Ctnnb1 recombinant protein  >67 publications with Psen1 and Ctnnb1
 Psenen recombinant protein  >57 publications with Psen1 and Psenen
 Notch1 recombinant protein  >47 publications with Psen1 and Notch1
 Aph1a recombinant protein  >39 publications with Psen1 and Aph1a
 Ncstn recombinant protein  >19 publications with Psen1 and Ncstn
 Aph1b recombinant protein  >7 publications with Psen1 and Aph1b
 Notch4 recombinant protein  >4 publications with Psen1 and Notch4
 Notch2 recombinant protein  >3 publications with Psen1 and Notch2
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
 Neutrophil Degranulation Pathway antibodies  Neutrophil Degranulation Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
Diseases associated with Psen1 recombinant proteinOrgans/Tissues associated with Psen1 recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1886 publications with Psen1 and Nervous System Diseases
 Alzheimer Disease Antibodies  >1877 publications with Psen1 and Alzheimer Disease
 Neurodegenerative Diseases Antibodies  >1836 publications with Psen1 and Neurodegenerative Diseases
 Disease Models, Animal Antibodies  >489 publications with Psen1 and Disease Models, Animal
 Memory Disorders Antibodies  >172 publications with Psen1 and Memory Disorders
 Cognition Disorders Antibodies  >114 publications with Psen1 and Cognition Disorders
 Learning Disorders Antibodies  >108 publications with Psen1 and Learning Disorders
 Amyloidosis Antibodies  >76 publications with Psen1 and Amyloidosis
 Frontotemporal Dementia Antibodies  >74 publications with Psen1 and Frontotemporal Dementia
 Inflammation Antibodies  >70 publications with Psen1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1172 publications with Psen1 and Brain
 Kidney Antibodies  >57 publications with Psen1 and Kidney
 Embryonic Tissue Antibodies  >31 publications with Psen1 and Embryonic Tissue
 Muscle Antibodies  >25 publications with Psen1 and Muscle
 Liver Antibodies  >20 publications with Psen1 and Liver
 Eye Antibodies  >16 publications with Psen1 and Eye
 Heart Antibodies  >16 publications with Psen1 and Heart
 Ovary Antibodies  >10 publications with Psen1 and Ovary
 Spleen Antibodies  >9 publications with Psen1 and Spleen
 Lung Antibodies  >8 publications with Psen1 and Lung
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