NP_062036.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,790 Da
NCBI Official Full Name
presenilin-1
NCBI Official Synonym Full Names
presenilin 1
NCBI Protein Information
presenilin-1
UniProt Protein Name
Presenilin-1
UniProt Synonym Protein Names
Protein S182
UniProt Synonym Gene Names
NCBI Summary for Psen1
multitransmembrane protein; human homolog mutated in most cases of early onset familial Alzheimer's disease; may mediate retinal lamination and pattern formation [RGD, Feb 2006]
UniProt Comments for Psen1
Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (). Required for normal embryonic brain and skeleton development, and for normal angiogenesis ().
Research Articles on Psen1
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Products associated with Psen1 recombinant protein
Pathways associated with Psen1 recombinant protein
Diseases associated with Psen1 recombinant protein
Organs/Tissues associated with Psen1 recombinant protein
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