NP_001165599.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
59,345 Da
NCBI Official Full Name
pro-interleukin-16 isoform 3
NCBI Official Synonym Full Names
interleukin 16
NCBI Protein Information
pro-interleukin-16
UniProt Protein Name
Pro-interleukin-16
UniProt Synonym Protein Names
Interleukin-16; IL-16
UniProt Synonym Gene Names
NCBI Summary for IL16
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
UniProt Comments for IL16
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.
Research Articles on IL16
Precautions
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Disclaimer
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Products associated with IL16 recombinant protein
Diseases associated with IL16 recombinant protein
Organs/Tissues associated with IL16 recombinant protein
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