NP_001128142.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,954 Da
NCBI Official Full Name
4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform 2
NCBI Official Synonym Full Names
4-hydroxy-2-oxoglutarate aldolase 1
NCBI Official Synonym Symbols
HP3; NPL2; DHDPS2; DHDPSL; C10orf65 [Similar Products]
NCBI Protein Information
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
UniProt Protein Name
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
UniProt Synonym Protein Names
Dihydrodipicolinate synthase-like; DHDPS-like protein; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase; Protein 569272
UniProt Synonym Gene Names
NCBI Summary for HOGA1
The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
UniProt Comments for HOGA1
Catalyzes the final step in the metabolic pathway of hydroxyproline.
Research Articles on HOGA1
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Products associated with HOGA1 recombinant protein
Pathways associated with HOGA1 recombinant protein
Diseases associated with HOGA1 recombinant protein
Organs/Tissues associated with HOGA1 recombinant protein
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