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PENK recombinant protein :: Proenkephalin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2033127 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $255 +1 FREE 8GB USB
0.1 mg  /  $390 +1 FREE 8GB USB
0.2 mg  /  $480 +1 FREE 8GB USB
0.5 mg  /  $935 +1 FREE 8GB USB
1 mg  /  $1,380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proenkephalin (PENK), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Proenkephalin (PENK)

 Product Synonym Names    Preproenkephalin; Proenkephalin-A; Synenkephalin; Met-enkephalin; Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; Met-enkephalin-Arg-Phe
 Product Gene Name   

PENK recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Proenkephalin (MBS2032538)
Antigen: Proenkephalin (MBS2033127)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2033127 Technical Datasheet    Technical Datasheet PDF
 Host    E Coli
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 Purity/Purification    > 90%
 Concentration    Original Concentration: 200 ug/mL (lot specific)
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 Organism Species    Homo sapiens (Human)
 Source    Prokaryotic expression
 Residues    Glu25~Phe267
 Tags    N-terminal His Tag
 Subcellular Location    Secreted
 Traits    Freeze-dried powder
 Buffer    100mMNaHCO3, 500mMNaCl, pH8.3, containing 0.01% SKL, 5% Trehalose.
 Predicted isoelectric point    5.3
 Predicted Molecular Mass    31.9kDa
 Accurate Molecular Mass    35kDa as determined by SDS-PAGE reducing conditions.
 Phenomenon explanation    The possible reasons that the actual band size differs from the predicted are as follows:
1.Splice variants: Alternative splicing may create different sized proteins from the same gene..
2. Relative charge: The composition of amino acids may affects the charge of the protein.
3. Post%translational modification: Phosphorylation, glycosylation, methylation etc.
4. Post%translation cleavage: Many proteins are synthesized as pro%proteins, and then cleaved to give the active form.
5. Polymerization of the target protein: Dimerization, multimerization etc.
 Usage    Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.

Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of PENK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for PENK recombinant protein   

SDS-PAGE, Western (WB), Positive Control, Immunogen

(May be suitable for use in other assays to be determined by the end user.)

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 SDS-Page of PENK recombinant protein    PENK recombinant protein SDS-Page image
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 Testing Data (TD) of PENK recombinant protein    Sequence
PENK recombinant protein Testing Data (TD) image
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NCBI/Uniprot data below describe general gene information for PENK. It may not necessarily be applicable to this product.
 NCBI GI #    259153
 NCBI GeneID    29237
 NCBI Accession #    AAB24022.1 [Other Products]
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 UniProt Secondary Accession #    Q53X05 [Other Products]
 UniProt Related Accession #    P04094 [Other Products]
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 NCBI Official Full Name    proenkephalin
 NCBI Official Synonym Full Names    proenkephalin
 NCBI Official Symbol    Penk [Similar Products]
 NCBI Official Synonym Symbols   
Enk; Penk1; Penk2; Penk-rs
[Similar Products]
 NCBI Protein Information    proenkephalin-A
 UniProt Protein Name    Proenkephalin-A
 UniProt Synonym Protein Names   
SynenkephalinMet-enkephalinAlternative name(s):Opioid growth factor; OGF
 Protein Family    Proenkephalin
 UniProt Gene Name    Penk [Similar Products]
 UniProt Synonym Gene Names    Penk-rs; Penk1; OGF [Similar Products]
 UniProt Entry Name    PENK_RAT
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 NCBI Summary for PENK    neuropeptide hormone; plays a role in the responses to stress and pain perception [RGD, Feb 2006]
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 UniProt Comments for PENK    PENK: Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. Belongs to the opioid neuropeptide precursor family.

Protein type: Secreted, signal peptide; Hormone; Secreted
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 Research Articles on PENK    1. results suggest that a DeltaFosB-mediated downregulation of enkephalin in the nucleus accumbens might underlie the susceptibility to chronic stress
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PENK recombinant proteinPathways associated with PENK recombinant protein
 Reference Product  PubMed Publications
 Pdyn recombinant protein  >50 publications with PENK and Pdyn
 Pomc recombinant protein  >36 publications with PENK and Pomc
 Npy recombinant protein  >7 publications with PENK and Npy
 Pnoc recombinant protein  >5 publications with PENK and Pnoc
 Oprm1 recombinant protein  >4 publications with PENK and Oprm1
 Oprd1 recombinant protein  >3 publications with PENK and Oprd1
 Drd2 recombinant protein  >3 publications with PENK and Drd2
 Oprl1 recombinant protein  >2 publications with PENK and Oprl1
 Gal recombinant protein  >1 publications with PENK and Gal
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with PENK recombinant proteinOrgans/Tissues associated with PENK recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >39 publications with PENK and Nervous System Diseases
 Opioid-Related Disorders Antibodies  >33 publications with PENK and Opioid-Related Disorders
 Brain Diseases Antibodies  >26 publications with PENK and Brain Diseases
 Pain Antibodies  >18 publications with PENK and Pain
 Disease Models, Animal Antibodies  >18 publications with PENK and Disease Models, Animal
 Movement Disorders Antibodies  >13 publications with PENK and Movement Disorders
 Poisoning Antibodies  >9 publications with PENK and Poisoning
 Anxiety Disorders Antibodies  >9 publications with PENK and Anxiety Disorders
 Seizures Antibodies  >7 publications with PENK and Seizures
 Cocaine-Related Disorders Antibodies  >7 publications with PENK and Cocaine-Related Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >128 publications with PENK and Brain
 Heart Antibodies  >13 publications with PENK and Heart
 Pituitary Gland Antibodies  >6 publications with PENK and Pituitary Gland
 Prostate Antibodies  >5 publications with PENK and Prostate
 Eye Antibodies  >5 publications with PENK and Eye
 Embryonic Tissue Antibodies  >2 publications with PENK and Embryonic Tissue
 Testis Antibodies  >1 publications with PENK and Testis
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